Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells

(2020) Yong Hou et al.   Small

Ligand Diffusion Enables Force‐Independent Cell Adhesion via Activating α5β1 Integrin and Initiating Rac and RhoA Signaling

(2020) Leixiao Yu et al.   ADVANCED MATERIALS

Anisotropic Nanoscale Presentation of Cell Adhesion Ligand Enhances the Recruitment of Diverse Integrins in Adhesion Structures and Mechanosensing-Dependent Differentiation of Stem Cells

(2019) Siu Hong Dexter Wong et al.   ADVANCED FUNCTIONAL MATERIALS

Surface Immobilized E‐Cadherin Mimetic Peptide Regulates the Adhesion and Clustering of Epithelial Cells

(2019) Jie Li et al.   Advanced Healthcare Materials

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

(2019) Hong-pyo Lee et al.   Nature Communications

Biochemical Ligand Density Regulates Yes-Associated Protein Translocation in Stem Cells through Cytoskeletal Tension and Integrins

(2019) Alice E. Stanton et al.   ACS Applied Materials & Interfaces

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Microchannel Stiffness and Confinement Jointly Induce the Mesenchymal-Amoeboid Transition of Cancer Cell Migration

(2019) Meng Wang et al.   NANO LETTERS

Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

(2019) Rishita Changede et al.   NATURE MATERIALS

Five Piconewtons: The Difference between Osteogenic and Adipogenic Fate Choice in Human Mesenchymal Stem Cells

(2019) Pingping Han et al.   ACS Nano

Surface Roughness and Substrate Stiffness Synergize To Drive Cellular Mechanoresponse

(2019) Yong Hou et al.   NANO LETTERS

Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

(2018) Heemin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids

(2018) Dexu Kong et al.   NANO LETTERS

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Bioengineering strategies to accelerate stem cell therapeutics

(2018) Christopher M. Madl et al.   NATURE

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

(2018) Giovanna Brusatin et al.   NATURE MATERIALS

Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells

(2018) Anouk R. Killaars et al.   Advanced Science

Steps in Mechanotransduction Pathways that Control Cell Morphology

(2018) Haguy Wolfenson et al.   Annual Review of Physiology

Cell–Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research

(2017) Andrew W. Holle et al.   NANO LETTERS

Force loading explains spatial sensing of ligands by cells

(2017) Roger Oria et al.   NATURE

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

(2017) Jeong-Ki Kim et al.   Nature Communications

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

(2017) Kevin J. De France et al.   Advanced Healthcare Materials

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

(2017) Tobias G. Kapp et al.   Scientific Reports

Improved Endothelial Function of Endothelial Cell Monolayer on the Soft Polyelectrolyte Multilayer Film with Matrix-Bound Vascular Endothelial Growth Factor

(2016) Hao Chang et al.   ACS Applied Materials & Interfaces

αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating

(2016) Carlos Mas-Moruno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrate Stiffness Combined with Hepatocyte Growth Factor Modulates Endothelial Cell Behavior

(2016) Hao Chang et al.   BIOMACROMOLECULES

Phototriggered fibril-like environments arbitrate cell escapes and migration from endothelial monolayers

(2016) Marcelo J. Salierno et al.   BIOMATERIALS

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

(2016) Abhishek Kumar et al.   JOURNAL OF CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Advancing biomaterials of human origin for tissue engineering

(2016) Fa-Ming Chen et al.   PROGRESS IN POLYMER SCIENCE

Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing–thawing method to investigate stem cell differentiation behaviors

(2015) Tae Ho Kim et al.   BIOMATERIALS

Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

(2015) Kai Ye et al.   NANO LETTERS

Forcing cells into shape: the mechanics of actomyosin contractility

(2015) Michael Murrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue

(2013) D. Adam Young et al.   BIOMATERIALS

Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids

(2013) Alexander Bochen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells

(2012) Ana M.C. Barradas et al.   BIOMATERIALS

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape

(2011) O. Gay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

High Intracellular Iron Oxide Nanoparticle Concentrations Affect Cellular Cytoskeleton and Focal Adhesion Kinase-Mediated Signaling

(2010) Stefaan J. H. Soenen et al.   Small

Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion

(2009) Jinghuan Huang et al.   NANO LETTERS

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Cell adhesion and polarisation on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patches

(2008) V HIRSCHFELDWARNEKEN et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY