αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating

Synthesis of Binary Nanopatterns on Hydrogels for Initiating Cellular Responses

(2016) Judith Guasch et al.   CHEMISTRY OF MATERIALS

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin

(2016) Dimitris Missirlis et al.   Scientific Reports

Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions

(2015) Judith Guasch et al.   ADVANCED MATERIALS

Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity

(2015) Tobias G. Kapp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simple coating with fibronectin fragment enhances stainless steel screw osseointegration in healthy and osteoporotic rats

(2015) Rachit Agarwal et al.   BIOMATERIALS

Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma

(2015) G Renner et al.   CELL DEATH AND DIFFERENTIATION

Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium

(2015) Roberta Fraioli et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Metabolism and disposition of the αv-integrin ß3/ß5 receptor antagonist cilengitide, a cyclic polypeptide, in humans

(2015) Andreas Becker et al.   JOURNAL OF CLINICAL PHARMACOLOGY

End of the road: confounding results of the CORE trial terminate the arduous journey of cilengitide for glioblastoma

(2015) W. P. Mason   NEURO-ONCOLOGY

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study

(2015) L. Burt Nabors et al.   NEURO-ONCOLOGY

Concise Review: Tailoring Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

(2015) Steffen Cosson et al.   Stem Cells Translational Medicine

Novel Peptide-Based Platform for the Dual Presentation of Biologically Active Peptide Motifs on Biomaterials

(2014) Carlos Mas-Moruno et al.   ACS Applied Materials & Interfaces

Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells

(2014) Anne-Marie Ray et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects

(2014) Martina A. Müller et al.   CELLULAR SIGNALLING

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

(2014) Paola Galletti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity

(2014) Stefanie Neubauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

(2014) Helen M. Sheldrake et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interface Immobilization Chemistry ofcRGD-based Peptides Regulates Integrin Mediated Cell Adhesion

(2013) Diego Pallarola et al.   ADVANCED FUNCTIONAL MATERIALS

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins

(2013) Sabri Rahmouni et al.   ADVANCED MATERIALS

Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3

(2013) Stefanie Neubauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced cell adhesion and mature intracellular structure promoted by squaramide-based RGD mimics on bioinert surfaces

(2013) Sri Kamesh Narasimhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion

(2013) Florian Rechenmacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Integrin modulators: a patent review

(2013) Tobias G Kapp et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids

(2013) Alexander Bochen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force

(2013) Martina A. Müller et al.   JOURNAL OF MOLECULAR BIOLOGY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Specific control of cell–material interactions: Targeting cell receptors using ligand-functionalized polymer substrates

(2013) Andrew E. Rodda et al.   PROGRESS IN POLYMER SCIENCE

Tumor Targeting via Integrin Ligands

(2013) Udaya Kiran Marelli et al.   Frontiers in Oncology

Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro

(2012) Florian Rechenmacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directing Stem Cell Fate by Controlling the Affinity and Density of Ligand-Receptor Interactions at the Biomaterials Interface

(2012) Kristopher A. Kilian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

αVβ3 Integrin Crystal Structures and Their Functional Implications

(2012) Xianchi Dong et al.   BIOCHEMISTRY

Polyethylene terephthalate membrane grafted with peptidomimetics: endothelial cell compatibility and retention under shear stress

(2012) Murielle Rémy et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides

(2012) Carlos Mas-Moruno et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Peptide-based activation of alpha5 integrin for promoting osteogenesis

(2012) Olivia Fromigué et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Engineering biocompatible implant surfaces

(2012) Sebastian Bauer et al.   PROGRESS IN MATERIALS SCIENCE

Tailored Integrin–Extracellular Matrix Interactions to Direct Human Mesenchymal Stem Cell Differentiation

(2012) Jessica Ellen Frith et al.   STEM CELLS AND DEVELOPMENT

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Small-Molecule-Modified Surfaces Engage Cells through the αvβ3 Integrin

(2011) Joseph R. Klim et al.   ACS Chemical Biology

Increasing αvβ3 Selectivity of the Anti-Angiogenic Drug Cilengitide by N-Methylation

(2011) Carlos Mas-Moruno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

The role of short synthetic adhesion peptides in regenerative medicine; The debate

(2011) David F. Williams   BIOMATERIALS

The role of β3-integrins in tumor angiogenesis: context is everything

(2011) Stephen D Robinson et al.   CURRENT OPINION IN CELL BIOLOGY

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

(2011) Ludwig Kappos et al.   LANCET NEUROLOGY

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Conformational Control of Integrin-Subtype Selectivity in isoDGR Peptide Motifs: A Biological Switch

(2010) Andreas O. Frank et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natalizumab and Progressive Multifocal Leukoencephalopathy

(2010) Clemens Warnke et al.   ARCHIVES OF NEUROLOGY

Small Molecule Antagonists of Integrin Receptors

(2010) A. Perdih et al.   CURRENT MEDICINAL CHEMISTRY

Endothelial  5 and  v integrins cooperate in remodeling of the vasculature during development

(2010) A. van der Flier et al.   DEVELOPMENT

α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

(2010) Eva Martinkova et al.   INTERNATIONAL JOURNAL OF CANCER

Extracellular matrix-mimetic adhesive biomaterials for bone repair

(2010) Asha Shekaran et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biomimeticity in tissue engineering scaffolds through synthetic peptide modifications-Altering chemistry for enhanced biological response

(2010) Kumaran G. Sreejalekshmi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efalizumab

(2009) James E Frampton et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Breaking the Dogma of the Metal-Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity

(2009) Dominik Heckmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Progressive Multifocal Leukoencephalopathy in Patients on Immunomodulatory Therapies

(2009) Eugene O. Major   Annual Review of Medicine

Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization

(2009) Grit Zahn   ARCHIVES OF OPHTHALMOLOGY

Discovery of orally available integrin α5β1 antagonists

(2009) Gunther Zischinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR of N-phenyl piperidine based oral integrin α5β1 antagonists

(2009) Gunther Zischinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

Giving off mixed signals-Distinct functions of α5β1and αvβ3integrins in regulating cell behaviour

(2009) Mark R. Morgan et al.   IUBMB LIFE

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

αvβ3Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

(2009) Vincent Rerat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antithrombotics in Acute Coronary Syndromes

(2009) Marc P. Bonaca et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Small Molecule Integrin Antagonists in Cancer Therapy

(2009) Mayra Paolillo et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Priming integrin  5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis

(2009) Z. Hamidouche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins

(2008) Rita Silva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration

(2008) Timothy A. Petrie et al.   BIOMATERIALS

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

(2008) Mikaël M. Martino et al.   BIOMATERIALS

Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor

(2008) Dominik Heckmann et al.   CHEMBIOCHEM

The role of cell adhesion pathways in angiogenesis

(2008) Antoine R. Ramjaun et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Extracellular matrix dynamics in development and regenerative medicine

(2008) W. P. Daley et al.   JOURNAL OF CELL SCIENCE

Simple application of fibronectin-mimetic coating enhances osseointegration of titanium implants

(2008) Timothy A. Petrie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipopeptide with a RGDK Tetrapeptide Sequence Can Selectively Target Genes to Proangiogenic α5β1 Integrin Receptor and Mouse Tumor Vasculature

(2008) Dipankar Pramanik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY