Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems

Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses

(2020) Cristina I. Øie et al.   Scientific Reports

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modeling neural circuit, blood-brain barrier, and myelination on a microfluidic 96 well plate

(2019) Seung-Ryeol Lee et al.   Biofabrication

Renal reabsorption in 3D vascularized proximal tubule models

(2019) Neil Y. C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

(2019) Jungwook Paek et al.   ACS Nano

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

(2019) Haitao Liu et al.   ADVANCED MATERIALS

Bioprinters for organs-on-chips

(2019) Amir Miri et al.   Biofabrication

Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells

(2019) Philipp Wörsdörfer et al.   Scientific Reports

Progress in 3D bioprinting technology for tissue/organ regenerative engineering

(2019) Ishita Matai et al.   BIOMATERIALS

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

(2018) Lorna Ewart et al.   Annual Review of Pharmacology and Toxicology

Does soft really matter? Differentiation of induced pluripotent stem cells into mesenchymal stromal cells is not influenced by soft hydrogels

(2018) Roman Goetzke et al.   BIOMATERIALS

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Microfluidics within a well: an injection-molded plastic array 3D culture platform

(2018) Younggyun Lee et al.   LAB ON A CHIP

Myocardial Stiffness Evaluation Using Noninvasive Shear Wave Imaging in Healthy and Hypertrophic Cardiomyopathic Adults

(2018) Olivier Villemain et al.   JACC-Cardiovascular Imaging

Multiscale bioprinting of vascularized models

(2018) Amir K. Miri et al.   BIOMATERIALS

Functionalizing bioinks for 3D bioprinting applications

(2018) Azraa Parak et al.   DRUG DISCOVERY TODAY

Increased myocardial stiffness activates cardiac microvascular endothelial cell via VEGF paracrine signaling in cardiac hypertrophy

(2018) Jian Shen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Engineering biofunctional in vitro vessel models using a multilayer bioprinting technique

(2018) Jan Schöneberg et al.   Scientific Reports

The micromechanics of lung alveoli: structure and function of surfactant and tissue components

(2018) Lars Knudsen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Glass-based organ-on-a-chip device for restricting small molecular absorption

(2018) Hirotada Hirama et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Modeling organ-specific vasculature with organ-on-a-chip devices

(2018) Dawn S Y Lin et al.   NANOTECHNOLOGY

Basement membrane and blood–brain barrier

(2018) Lingling Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Tumour-vessel-on-a-chip models for drug delivery

(2017) David Caballero et al.   LAB ON A CHIP

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Three-Dimensional Printing and Angiogenesis: Tailored Agarose-Type I Collagen Blends Comprise Three-Dimensional Printability and Angiogenesis Potential for Tissue-Engineered Substitutes

(2017) Franziska Kreimendahl et al.   TISSUE ENGINEERING PART C-METHODS

Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

(2017) Samad Ahadian et al.   Advanced Healthcare Materials

Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug Delivery

(2016) Yoonjee C. Park et al.   ACS Applied Materials & Interfaces

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink

(2016) Weitao Jia et al.   BIOMATERIALS

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model

(2016) Sudong Kim et al.   LAB ON A CHIP

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

(2016) Xiaolin Wang et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

Biosynthetic Polymers as Functional Materials

(2016) Andrea S. Carlini et al.   MACROMOLECULES

Laser-based in situ embedding of metal nanoparticles into bioextruded alginate hydrogel tubes enhances human endothelial cell adhesion

(2016) Andreas Blaeser et al.   Nano Research

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Cellular Determinants of Renal Glomerular Elasticity

(2016) Addie E. Embry et al.   PLoS One

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

A multilayered microfluidic blood vessel-like structure

(2015) Anwarul Hasan et al.   BIOMEDICAL MICRODEVICES

Tissue vascularization through 3D printing: Will technology bring us flow?

(2015) S.J. Paulsen et al.   DEVELOPMENTAL DYNAMICS

The cell biology of renal filtration

(2015) Rizaldy P. Scott et al.   JOURNAL OF CELL BIOLOGY

Review: in vitro microvessel models

(2015) Max I. Bogorad et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Creating perfused functional vascular channels using 3D bio-printing technology

(2014) Vivian K. Lee et al.   BIOMATERIALS

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Generation of Multi-scale Vascular Network System Within 3D Hydrogel Using 3D Bio-printing Technology

(2014) Vivian K. Lee et al.   Cellular and Molecular Bioengineering

The Glomerulus: The Sphere of Influence

(2014) M. R. Pollak et al.   Clinical Journal of the American Society of Nephrology

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

(2014) Luiz E. Bertassoni et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Tissue mechanics and fibrosis

(2013) Rebecca G. Wells   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Hydrogel-coated microfluidic channels for cardiomyocyte culture

(2013) Nasim Annabi et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Fabrication of Nature-Inspired Microfluidic Network for Perfusable Tissue Constructs

(2013) Jiankang He et al.   Advanced Healthcare Materials

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Integration of Self-Assembled Microvascular Networks with Microfabricated PEG-Based Hydrogels

(2012) Michael P. Cuchiara et al.   ADVANCED FUNCTIONAL MATERIALS

Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels

(2012) Ying-Chieh Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Breast cancer cell-derived matrix supports vascular morphogenesis

(2012) Abigail C. Hielscher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

The integration of 3-D cell printing and mesoscopic fluorescence molecular tomography of vascular constructs within thick hydrogel scaffolds

(2012) Lingling Zhao et al.   BIOMATERIALS

Induced Pluripotent Stem Cells: Past, Present, and Future

(2012) Shinya Yamanaka   Cell Stem Cell

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells

(2012) Aleksander Skardal et al.   Journal of the Mechanical Behavior of Biomedical Materials

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

(2012) Ju Hun Yeon et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Perfusable branching microvessel bed for vascularization of engineered tissues

(2012) L. L. Y. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide

(2011) Julia E. Leslie-Barbick et al.   BIOMATERIALS

Cultured cell-derived extracellular matrix scaffolds for tissue engineering

(2011) Hongxu Lu et al.   BIOMATERIALS

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

(2010) Régis Baudoin et al.   BIOCHEMICAL ENGINEERING JOURNAL

Biomimetic hydrogels with pro-angiogenic properties

(2010) James J. Moon et al.   BIOMATERIALS

The isolation of cell derived extracellular matrix constructs using sacrificial open-cell foams

(2010) Jeffrey C. Wolchok et al.   BIOMATERIALS

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Biomimetic materials in tissue engineering

(2010) Jennifer Patterson et al.   Materials Today

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Microfluidic Culture Models of Tumor Angiogenesis

(2010) Abraham D. Stroock et al.   TISSUE ENGINEERING PART A

Scaffold-free vascular tissue engineering using bioprinting

(2009) Cyrille Norotte et al.   BIOMATERIALS

Recent developments in PDMS surface modification for microfluidic devices

(2009) Jinwen Zhou et al.   ELECTROPHORESIS

The cardiovascular unit as a dynamic player in disease and regeneration

(2009) Simonetta Ausoni et al.   TRENDS IN MOLECULAR MEDICINE