Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms

Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments

(2020) Fuming Li et al.   DEVELOPMENTAL CELL

Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis

(2020) Samantha R. Soncini et al.   PLoS Genetics

AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking

(2019) Allyson F. O’Donnell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose

(2019) Quentin Defenouillère et al.   Science Signaling

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

(2019) Samson Mathews Samuel et al.   Cancers

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

(2019) B. Pajak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

EXTH-07. DESIGN AND EVALUATION OF WP1122, AN INHIBITOR OF GLYCOLYSIS WITH INCREASED CNS UPTAKE.

(2018) Waldemar Priebe et al.   NEURO-ONCOLOGY

Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis

(2017) Junie Hovsepian et al.   JOURNAL OF CELL BIOLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells

(2017) Linlin Sun et al.   PLoS One

Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro

(2017) Maruša Bizjak et al.   Scientific Reports

Metformin

(2016) Meng H. Tan et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein

(2016) Vicent Llopis-Torregrosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT-1 Dependent Mechanism

(2016) Haritha Kunhiraman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Expanding Landscape of Moonlighting Proteins in Yeasts

(2016) Carlos Gancedo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

(2016) Simona Kavaliauskiene et al.   Oncotarget

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Regulation of AMP-activated protein kinase by natural and synthetic activators

(2016) David Grahame Hardie   Acta Pharmaceutica Sinica B

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids

(2015) Simona Kavaliauskiene et al.   BIOCHEMICAL JOURNAL

Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing

(2015) Yong Wu et al.   BREAST CANCER RESEARCH AND TREATMENT

Protein Kinase Ymr291w/Tda1 Is Essential for Glucose Signaling inSaccharomyces cerevisiaeon the Level of Hexokinase Isoenzyme ScHxk2 Phosphorylation*

(2015) Sonja Kaps et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases fromSaccharomyces cerevisiae

(2015) Ekaterina Kuznetsova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The anti-angiogenic action of 2-deoxyglucose involves attenuation of VEGFR2 signaling and MMP-2 expression in HUVECs

(2015) I-Chen Chuang et al.   LIFE SCIENCES

2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3  Activation

(2015) K. Kovacs et al.   MOLECULAR CANCER THERAPEUTICS

Research into cancer metabolomics: Towards a clinical metamorphosis

(2015) Orianne Olivares et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic Analysis of Resistance and Sensitivity to 2-Deoxyglucose in Saccharomyces cerevisiae

(2014) R. R. McCartney et al.   GENETICS

The wonders of 2-deoxy-d-glucose

(2014) Haibin Xi et al.   IUBMB LIFE

2-Deoxyglucose Impairs Saccharomyces cerevisiae Growth by Stimulating Snf1-Regulated and α-Arrestin-Mediated Trafficking of Hexose Transporters 1 and 3

(2014) Allyson F. O'Donnell et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling

(2014) K. A. Braun et al.   Science Signaling

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

(2013) Haibin Xi et al.   BIOCHEMICAL PHARMACOLOGY

Comparative Analysis of the Expression Patterns of UPR-Target Genes Caused by UPR-Inducing Compounds

(2013) Satoko SHINJO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

(2013) Huaping Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions

(2013) Colin R. Kennedy et al.   CANCER LETTERS

Ptc1 Protein Phosphatase 2C Contributes to Glucose Regulation of SNF1/AMP-activated Protein Kinase (AMPK) inSaccharomyces cerevisiae

(2013) Amparo Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Glucose Transporters in Aspergillus nidulans

(2013) Thaila Fernanda dos Reis et al.   PLoS One

Activation of the Unfolded Protein Response by 2-Deoxy-d-Glucose Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication and Gene Expression

(2012) Howard J. Leung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis

(2012) Eva Apweiler et al.   BMC GENOMICS

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis

(2012) Michel Becuwe et al.   JOURNAL OF CELL BIOLOGY

2-Deoxy D-Glucose Prevents Cell Surface Expression of NKG2D Ligands through Inhibition of N-Linked Glycosylation

(2012) L. Andresen et al.   JOURNAL OF IMMUNOLOGY

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response

(2012) M. Beneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

(2011) S. Ramirez-Peinado et al.   CANCER RESEARCH

ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase

(2011) Faith V. Mayer et al.   Cell Metabolism

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy

(2011) Ryuji Yamaguchi et al.   PLoS One

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5′-phosphatase

(2010) Alice Preumont et al.   BIOCHEMICAL JOURNAL

Functional domains of yeast hexokinase 2

(2010) Rafael Peláez et al.   BIOCHEMICAL JOURNAL

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

(2010) Haibin Xi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Expansion of Hexose Transporter Genes Was Associated with the Evolution of Aerobic Fermentation in Yeasts

(2010) Z. Lin et al.   MOLECULAR BIOLOGY AND EVOLUTION

Antiangiogenic Activity of 2-Deoxy-D-Glucose

(2010) Jaime R. Merchan et al.   PLoS One

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy

(2009) H. Wu et al.   CANCER RESEARCH

The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R

(2009) Diansheng Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects

(2009) BS Dwarakanath et al.   Journal of Cancer Research and Therapeutics

2-[18f]-2-deoxy-d-glucose (fdg) uptake in human tumor cells is related to the expression of glut-1 and hexokinase ii

(2008) L.-C. Ong et al.   ACTA RADIOLOGICA

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

(2008) D. Zhong et al.   MOLECULAR CANCER THERAPEUTICS

Modulation of the activities of AMP‐activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2‐deoxyglucose

(2008) Weiqin Jiang et al.   MOLECULAR CARCINOGENESIS

Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast

(2008) Brendon J Monahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth

(2008) M. Ralser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy

(2008) Robert S. DiPaola et al.   PROSTATE