Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis

(2010) Jerry E. Chipuk et al.   CELL CYCLE

Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells

(2010) A Caro-Maldonado et al.   CELL DEATH AND DIFFERENTIATION

Targeting mitochondria for cancer therapy

(2010) David M. Hockenbery   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1

(2009) Ryuji Yamaguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK

(2009) T W Owens et al.   CELL DEATH AND DIFFERENTIATION

The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R

(2009) Diansheng Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl-xLincreases mitochondrial fission, fusion, and biomass in neurons

(2009) Sarah B. Berman et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737

(2009) P. Hauck et al.   MOLECULAR CANCER THERAPEUTICS

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation

(2009) L A Pradelli et al.   ONCOGENE

Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer

(2008) M. L. Hyer et al.   CANCER RESEARCH

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

(2008) C. L. Hann et al.   CANCER RESEARCH

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells

(2008) M Vogler et al.   CELL DEATH AND DIFFERENTIATION

Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib

(2008) A Hochhaus et al.   LEUKEMIA

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

(2008) D. Zhong et al.   MOLECULAR CANCER THERAPEUTICS

Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

(2008) Ryuji Yamaguchi et al.   MOLECULAR CELL

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON