Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species‐mediated mitochondrial injury

(2020) Cristina M. Castro et al.   FASEB JOURNAL

Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury

(2020) Jianbin Bi et al.   Oxidative Medicine and Cellular Longevity

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis

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The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis

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Interplay between genetics and epigenetics in osteoarthritis

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Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis

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MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

(2020) L. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes

(2020) Stefania D'Adamo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Irisin deficiency disturbs bone metabolism

(2020) Xiaofang Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Irisin Recovers Osteoarthritic Chondrocytes In Vitro

(2020) Gianluca Vadalà et al.   Cells

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Fndc5 loss-of-function attenuates exercise-induced browning of white adipose tissue in mice

(2019) Yan Xiong et al.   FASEB JOURNAL

Osteoarthritis

(2019) David J Hunter et al.   LANCET

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

(2019) Michael L.-H. Huang et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Transfer of Wharton’s Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts

(2019) Tsu-Kung Lin et al.   Oxidative Medicine and Cellular Longevity

Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation

(2019) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis

(2019) A.K. Carlson et al.   OSTEOARTHRITIS AND CARTILAGE

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis

(2019) Hyo Jung Shin et al.   Journal of Clinical Medicine

Irisin Prevents Disuse‐Induced Osteocyte Apoptosis

(2019) Giuseppina Storlino et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fndc5 knockdown induced suppression of mitochondrial integrity and significantly decreased cardiac differentiation of mouse embryonic stem cells

(2018) Shima Nazem et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes

(2018) M.Y. Ansari et al.   OSTEOARTHRITIS AND CARTILAGE

Activation of AMPK-SIRT3 Signaling is Chondroprotective by Preserving Mitochondrial DNA Integrity and Function

(2018) Liang-Yu Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

(2018) Mitchell C. Coleman et al.   Science Translational Medicine

Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway

(2018) Ru-Li Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

(2018) Wei-Shiung Lian et al.   Cell Death & Disease

Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR

(2018) Wei-Shiung Lian et al.   Cell Death & Disease

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy

(2018) Weiwei Zheng et al.   FASEB JOURNAL

Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo

(2018) Dongwook Yeo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR

(2018) Mian Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice

(2018) Yvonne Rellmann et al.   Oxidative Medicine and Cellular Longevity

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

(2018) Jianbin Bi et al.   Redox Biology

Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction

(2017) Mark Nøhr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of metabolism in the pathogenesis of osteoarthritis

(2017) Ali Mobasheri et al.   Nature Reviews Rheumatology

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

(2017) Ken Chen et al.   Science Translational Medicine

Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

(2017) Hui Peng et al.   Nature Communications

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

(2017) Musarrat Maisha Reza et al.   Nature Communications

MicroRNA-29a Counteracts Synovitis in Knee Osteoarthritis Pathogenesis by Targeting VEGF

(2017) Jih-Yang Ko et al.   Scientific Reports

Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study

(2016) Mercedes Fernández-Moreno et al.   ANNALS OF THE RHEUMATIC DISEASES

FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice

(2016) Tong-Yan Liu et al.   DIABETES

Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis

(2016) Jih-Yang Ko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Autophagy in Human Health and Disease

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics

(2011) Jyh-Ying Peng et al.   PLoS Computational Biology

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols