Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice

Epiphyseal growth plate architecture is unaffected by early postnatal activation of the expression of R992C collagen II mutant

(2018) Jolanta Fertala et al.   BONE

Impact of Arginine to Cysteine Mutations in Collagen II on Protein Secretion and Cell Survival

(2018) Salin Chakkalakal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multifunctional molecule ERp57: From cancer to neurodegenerative diseases

(2018) Aubryanna Hettinghouse et al.   PHARMACOLOGY & THERAPEUTICS

PERK-mediated translational control is required for collagen secretion in chondrocytes

(2018) Satoshi Hisanaga et al.   Scientific Reports

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

(2018) Cheng Wang et al.   eLife

Endoplasmic Reticulum Stress and Unfolded Protein Response in Cartilage Pathophysiology; Contributing Factors to Apoptosis and Osteoarthritis

(2017) Alexandria Hughes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner

(2017) Xiaomin Kang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased intracellular proteolysis reduces disease severity in an ER stress–associated dwarfism

(2017) Lorna A. Mullan et al.   JOURNAL OF CLINICAL INVESTIGATION

Biology of Hsp47 (Serpin H1), a collagen-specific molecular chaperone

(2017) Shinya Ito et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endoplasmic reticulum stress in chondrodysplasias caused by mutations in collagen types II and X

(2016) Katarzyna Gawron   CELL STRESS & CHAPERONES

The unfolded protein response in skeletal development and homeostasis

(2016) Keisuke Horiuchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein quality control at the endoplasmic reticulum

(2016) K. McCaffrey et al.   Essays in Biochemistry

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

(2016) Azam Hosseinzadeh et al.   JOURNAL OF PINEAL RESEARCH

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Nosology and classification of genetic skeletal disorders: 2015 revision

(2015) Luisa Bonafe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mechanisms of Aberrant Organization of Growth Plates in Conditional Transgenic Mouse Model of Spondyloepiphyseal Dysplasia Associated with the R992C Substitution in Collagen II

(2015) Machiko Arita et al.   AMERICAN JOURNAL OF PATHOLOGY

ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice

(2015) Andrea Linz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization

(2015) T.L. Cameron et al.   OSTEOARTHRITIS AND CARTILAGE

Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

(2015) Louise H. W. Kung et al.   PLoS One

Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia

(2014) Sara E. Patterson et al.   DEVELOPMENTAL DYNAMICS

The many functions of the endoplasmic reticulum chaperones and folding enzymes

(2014) Laura Halperin et al.   IUBMB LIFE

XBP1S, a BMP2-inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor

(2014) Feng-Jin Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia

(2014) Katarzyna A. Piróg et al.   PLoS One

Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model

(2014) Guoyan Liang et al.   PLoS One

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Advanced glycation end-products induce endoplasmic reticulum stress in human aortic endothelial cells

(2013) Christos Adamopoulos et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

(2013) Soichiro Yamabe et al.   FEBS Journal

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases

(2013) Claire L. Hartley et al.   HUMAN MOLECULAR GENETICS

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

(2013) Atsushi Saito et al.   MOLECULAR CELL

Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions

(2013) Kimberly L. Cooper et al.   NATURE

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

(2013) P. A. Bell et al.   Biology Open

CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress

(2013) Faith Hall-Glenn et al.   Journal of Cell Communication and Signaling

The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation

(2012) Y. Masago et al.   JOURNAL OF CELL SCIENCE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The endoplasmic reticulum stress response in aging and age-related diseases

(2012) Marishka K. Brown et al.   Frontiers in Physiology

Autophagy in mineralizing tissues: Microenvironmental perspectives

(2011) Vickram Srinivas et al.   CELL CYCLE

A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia

(2011) Farhana Suleman et al.   HUMAN MUTATION

Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage

(2011) Koji Takada et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification

(2011) E J Mackie et al.   JOURNAL OF ENDOCRINOLOGY

Clinical phenotypes associated with type II collagen mutations

(2011) Peter Kannu et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Derlin-2-Deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes

(2011) S. K. Dougan et al.   MOLECULAR AND CELLULAR BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia

(2010) Seema Nundlall et al.   CELL STRESS & CHAPERONES

Early-onset progressive osteoarthritis with hereditary progressive ophtalmopathy or Stickler syndrome

(2010) Tifenn Couchouron et al.   JOINT BONE SPINE

The unfolded protein response and its relevance to connective tissue diseases

(2009) Raymond P. Boot-Handford et al.   CELL AND TISSUE RESEARCH

Transcriptional networks controlling skeletal development

(2009) Christine Hartmann   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cartilage and Bone Extracellular Matrix

(2009) Chiara Gentili/snm et al.   CURRENT PHARMACEUTICAL DESIGN

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

(2009) W. Wang et al.   DEVELOPMENT

ERp57 Modulates STAT3 Signaling from the Lumen of the Endoplasmic Reticulum

(2009) Helen Coe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1

(2009) Ashleigh E. Nugent et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

(2009) Atsushi Saito et al.   NATURE CELL BIOLOGY

N-glycan structures: recognition and processing in the ER

(2009) Markus Aebi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

(2009) M. Helen Rajpar et al.   PLoS Genetics

Substrate Specificity of the Oxidoreductase ERp57 Is Determined Primarily by Its Interaction with Calnexin and Calreticulin

(2008) Catherine E. Jessop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Getting In and Out from Calnexin/Calreticulin Cycles

(2008) Julio J. Caramelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic mice expressing D469Δ mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations

(2007) Markus Schmitz et al.   MATRIX BIOLOGY