Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

(2018) Meng-Yao Li et al.   BIOTECHNOLOGY PROGRESS

Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy

(2018) Thomas E. Matthews et al.   BIOTECHNOLOGY PROGRESS

Extraction of indirectly captured information for use in a comparison of offline pH measurement technologies

(2017) Elspeth K. Ritchie et al.   JOURNAL OF BIOTECHNOLOGY

pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays

(2017) K. Ehrlich et al.   OPTICS EXPRESS

The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion

(2017) Matthias Brunner et al.   Biotechnology Journal

Highly stable SERS pH nanoprobes produced by co-solvent controlled AuNP aggregation

(2016) Haoran Wei et al.   ANALYST

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale

(2016) Caspar Demuth et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy

(2015) Silvère André et al.   ANALYTICA CHIMICA ACTA

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Mid-infrared spectroscopy-based analysis of mammalian cell culture Parameters

(2015) Florian Capito et al.   BIOTECHNOLOGY PROGRESS

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Chemometrics-Based Process Analytical Technology (PAT) Tools: Applications and Adaptation in Pharmaceutical and Biopharmaceutical Industries

(2012) Shruthi Challa et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Studying the drift of in line pH measurements in cell culture

(2011) V. Saucedo et al.   BIOTECHNOLOGY PROGRESS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Following the Dynamics of pH in Endosomes of Live Cells with SERS Nanosensors

(2010) Janina Kneipp et al.   Journal of Physical Chemistry C

In situ monitoring of pH titration by Raman spectroscopy

(2010) M.A. Elbagerma et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways

(2010) Bhanu Chandra Mulukutla et al.   TRENDS IN BIOTECHNOLOGY

Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation

(2009) Albert E. Cervera et al.   BIOTECHNOLOGY PROGRESS

Development of high throughput optical sensor array for on-line pH monitoring in micro-scale cell culture environment

(2008) Min-Hsien Wu et al.   BIOMEDICAL MICRODEVICES

In situ 2D fluorometry and chemometric monitoring of mammalian cell cultures

(2008) Ana P. Teixeira et al.   BIOTECHNOLOGY AND BIOENGINEERING

SERS—a single-molecule and nanoscale tool for bioanalytics

(2008) Janina Kneipp et al.   CHEMICAL SOCIETY REVIEWS

pH prediction and control in bioprocesses using mid-infrared spectroscopy

(2007) Jonas Schenk et al.   BIOTECHNOLOGY AND BIOENGINEERING