High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development
出版年份 2020 全文链接
标题
High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development
作者
关键词
-
出版物
Processes
Volume 8, Issue 9, Pages 1179
出版商
MDPI AG
发表日期
2020-09-18
DOI
10.3390/pr8091179
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange
- (2020) Laura Rolinger et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
- (2020) Laura Rolinger et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Control of IgG glycosylation by in situ and real-time estimation of specific growth rate of CHO cells cultured in bioreactor
- (2019) Meng-Yao Li et al. BIOTECHNOLOGY AND BIOENGINEERING
- Prediction of the Quantity and Purity of an Antibody Capture Process in Real Time
- (2019) Nicole Walch et al. Biotechnology Journal
- A new flow cell and chemometric protocol for implementing in‐line Raman spectroscopy in chromatography
- (2019) Fabian Feidl et al. BIOTECHNOLOGY PROGRESS
- Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy
- (2019) Chi Zhang et al. ANALYTICA CHIMICA ACTA
- Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification
- (2019) Feidl et al. Processes
- Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes
- (2019) Carl Rafferty et al. BIOTECHNOLOGY AND BIOENGINEERING
- An NIR‐based PAT approach for real‐time control of loading in Protein A chromatography in continuous manufacturing of monoclonal antibodies
- (2019) Garima Thakur et al. BIOTECHNOLOGY AND BIOENGINEERING
- Application of Raman spectroscopy in monoclonal antibody producing continuous systems for downstream process intensification
- (2019) Denizhan Yilmaz et al. BIOTECHNOLOGY PROGRESS
- High-Throughput Screening Raman Spectroscopy Platform for Label-Free Cellomics
- (2018) Iwan W. Schie et al. ANALYTICAL CHEMISTRY
- Use of HPLC as an Enabler of Process Analytical Technology in Process Chromatography
- (2018) Anamika Tiwari et al. ANALYTICAL CHEMISTRY
- Development of generic raman models for a GS-KOTM CHO platform process
- (2018) Thaddaeus A. Webster et al. BIOTECHNOLOGY PROGRESS
- Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression
- (2018) Nina Brestrich et al. CHEMICAL ENGINEERING SCIENCE
- Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy
- (2018) Thomas E. Matthews et al. BIOTECHNOLOGY PROGRESS
- At‐line raman spectroscopy and design of experiments for robust monitoring and control of miniature bioreactor cultures
- (2018) Ruth C. Rowland‐Jones et al. BIOTECHNOLOGY PROGRESS
- Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
- (2017) Matthias Rüdt et al. JOURNAL OF CHROMATOGRAPHY A
- Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities
- (2017) Rebecca A. Chmielowski et al. JOURNAL OF CHROMATOGRAPHY A
- Real-time fouling monitoring with Raman spectroscopy
- (2017) Tiina Virtanen et al. JOURNAL OF MEMBRANE SCIENCE
- Rapid Identification of Biotherapeutics with Label-Free Raman Spectroscopy
- (2016) Santosh Kumar Paidi et al. ANALYTICAL CHEMISTRY
- Detection of Protein Glycosylation Using Tip-Enhanced Raman Scattering
- (2016) David P. Cowcher et al. ANALYTICAL CHEMISTRY
- Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes
- (2016) Matthias Brunner et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production
- (2016) Thomas E. Matthews et al. BIOTECHNOLOGY AND BIOENGINEERING
- Real-time monitoring and control of the load phase of a protein A capture step
- (2016) Matthias Rüdt et al. BIOTECHNOLOGY AND BIOENGINEERING
- In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy
- (2015) Silvère André et al. ANALYTICA CHIMICA ACTA
- Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations
- (2015) Chen Zhou et al. ANALYTICAL BIOCHEMISTRY
- Raman spectroscopy of complex defined media: biopharmaceutical applications
- (2015) Gajendra P. Singh et al. JOURNAL OF RAMAN SPECTROSCOPY
- Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
- (2015) Markus Haberger et al. mAbs
- At-line mid infrared spectroscopy for monitoring downstream processing unit operations
- (2015) Florian Capito et al. PROCESS BIOCHEMISTRY
- Universal Capacitance Model for Real-Time Biomass in Cell Culture
- (2015) Viktor Konakovsky et al. SENSORS
- Monitoring Antibody Aggregation in Early Drug Development Using Raman Spectroscopy and Perturbation-Correlation Moving Windows
- (2014) Ramón Gómez de la Cuesta et al. ANALYTICAL CHEMISTRY
- Performance of line-scan Raman microscopy for high-throughput chemical imaging of cell population
- (2014) Ji Qi et al. APPLIED OPTICS
- Fluorescence-based soft sensor for at situ monitoring of chinese hamster ovary cell cultures
- (2014) Kaveh Ohadi et al. BIOTECHNOLOGY AND BIOENGINEERING
- Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis
- (2014) Brandon Berry et al. BIOTECHNOLOGY PROGRESS
- Theory and practice of size exclusion chromatography for the analysis of protein aggregates
- (2014) Szabolcs Fekete et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller
- (2014) Stephen Craven et al. JOURNAL OF PROCESS CONTROL
- Application of an Online-Biomass Sensor in an Optical Multisensory Platform Prototype for Growth Monitoring of Biotechnical Relevant Microorganism and Cell Lines in Single-Use Shake Flasks
- (2014) Christian Ude et al. SENSORS
- Advances in size-exclusion separations of proteins and polymers by UHPLC
- (2014) Edouard S.P. Bouvier et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations
- (2013) M. Sandor et al. JOURNAL OF BIOTECHNOLOGY
- Chemometrics-Based Process Analytical Technology (PAT) Tools: Applications and Adaptation in Pharmaceutical and Biopharmaceutical Industries
- (2012) Shruthi Challa et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Host cell protein quantification by fourier transform mid infrared spectroscopy (FT-MIR)
- (2012) Florian Capito et al. BIOTECHNOLOGY AND BIOENGINEERING
- Rapid quantification of tryptophan and tyrosine in chemically defined cell culture media using fluorescence spectroscopy
- (2012) Amandine Calvet et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Monitoring the Glycosylation Status of Proteins Using Raman Spectroscopy
- (2011) Victoria L. Brewster et al. ANALYTICAL CHEMISTRY
- Versatile automated continuous flow system (VersAFlo) for bioanalysis and bioprocess control
- (2011) M.A. Kumar et al. SENSORS AND ACTUATORS B-CHEMICAL
- At-line NIR spectroscopy as effective PAT monitoring technique in Mab cultivations during process development and manufacturing
- (2011) Christian Hakemeyer et al. TALANTA
- Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe
- (2010) Nicholas R. Abu-Absi et al. BIOTECHNOLOGY AND BIOENGINEERING
- High-throughput cocrystal slurry screening by use of in situ Raman microscopy and multi-well plate
- (2010) Takashi Kojima et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started