Application of Raman spectroscopy in monoclonal antibody producing continuous systems for downstream process intensification

A machine‐learning approach to calibrate generic Raman models for real‐time monitoring of cell culture processes

(2019) Aditya Tulsyan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Parallel comparison of in situ Raman and NIR spectroscopies to simultaneously measure multiple variables toward real-time monitoring of CHO cell bioreactor cultures

(2018) Mengyao Li et al.   BIOCHEMICAL ENGINEERING JOURNAL

Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

(2018) Jean-Marc Bielser et al.   BIOTECHNOLOGY ADVANCES

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

(2018) Meng-Yao Li et al.   BIOTECHNOLOGY PROGRESS

Development of generic raman models for a GS-KOTM CHO platform process

(2018) Thaddaeus A. Webster et al.   BIOTECHNOLOGY PROGRESS

Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy

(2018) P. Barmpalexis et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing

(2018) Adam C. Fisher et al.   TRENDS IN BIOTECHNOLOGY

Shift to high‐intensity, low‐volume perfusion cell culture enabling a continuous, integrated bioprocess

(2018) Matthew Gagnon et al.   BIOTECHNOLOGY PROGRESS

Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy

(2018) Thomas E. Matthews et al.   BIOTECHNOLOGY PROGRESS

Upstream process intensification and continuous manufacturing

(2018) Chun Chen et al.   Current Opinion in Chemical Engineering

Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis

(2018) Alessandra Biancolillo et al.   Frontiers in Chemistry

In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

(2017) Hemlata Bhatia et al.   ENGINEERING IN LIFE SCIENCES

Transfer of a three step mAb chromatography process from batch to continuous: Optimizing productivity to minimize consumable requirements

(2017) Xhorxhi Gjoka et al.   JOURNAL OF BIOTECHNOLOGY

On-line prediction of the glucose concentration of CHO cell cultivations by NIR and Raman spectroscopy: Comparative scalability test with a shake flask model system

(2017) Bence Kozma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Rapid Identification of Biotherapeutics with Label-Free Raman Spectroscopy

(2016) Santosh Kumar Paidi et al.   ANALYTICAL CHEMISTRY

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy

(2015) Silvère André et al.   ANALYTICA CHIMICA ACTA

Continuous downstream processing for high value biological products: A Review

(2015) Andrew L. Zydney   BIOTECHNOLOGY AND BIOENGINEERING

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

(2015) Brandon N. Berry et al.   BIOTECHNOLOGY PROGRESS

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Mid-infrared spectroscopy-based analysis of mammalian cell culture Parameters

(2015) Florian Capito et al.   BIOTECHNOLOGY PROGRESS

Large-scale monoclonal antibody purification by continuous chromatography, from process design to scale-up

(2015) Valérie Girard et al.   JOURNAL OF BIOTECHNOLOGY

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

What's fueling the biotech engine—2012 to 2013

(2014) Saurabh (Rob) Aggarwal   NATURE BIOTECHNOLOGY

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

(2012) James Pollock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

(2011) Maria De Jesus et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Estimation of active pharmaceutical ingredients content using locally weighted partial least squares and statistical wavelength selection

(2011) Sanghong Kim et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

At-line NIR spectroscopy as effective PAT monitoring technique in Mab cultivations during process development and manufacturing

(2011) Christian Hakemeyer et al.   TALANTA

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING