Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes

Insights into pH-induced metabolic switch by flux balance analysis

(2015) Marija Ivarsson et al.   BIOTECHNOLOGY PROGRESS

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity

(2015) Tobias Klein et al.   JOURNAL OF BIOTECHNOLOGY

Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody

(2015) Cyrus D. Agarabi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody

(2014) L. M. Carrillo-Cocom et al.   CYTOTECHNOLOGY

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

In vitro and in vivo modifications of recombinant and human IgG antibodies

(2014) Hongcheng Liu et al.   mAbs

Dynamics of growth and metabolism controlled by glutamine availability in Chinese hamster ovary cells

(2013) Judith Wahrheit et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of monoclonal antibody size variants containing extra light chains

(2013) Connie Lu et al.   mAbs

Microbials for the production of monoclonal antibodies and antibody fragments

(2013) Oliver Spadiut et al.   TRENDS IN BIOTECHNOLOGY

Isomerization of Asp–Asp Motif in Model Peptides and a Monoclonal Antibody Fab Fragment

(2012) Li Yi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Galactosylation variations in marketed therapeutic antibodies

(2012) T. Shantha Raju et al.   mAbs

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

(2011) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells

(2011) Ying Jing et al.   PROCESS BIOCHEMISTRY

C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo

(2010) Bing Cai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell Engineering and Cultivation of Chinese Hamster Ovary (CHO) Cells

(2010) Takeshi Omasa et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY AND BIOENGINEERING

Error propagation from prime variables into specific rates and metabolic fluxes for mammalian cells in perfusion culture

(2009) Chetan T. Goudar et al.   BIOTECHNOLOGY PROGRESS

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

(2008) Lawrence W. Dick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES