Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

Targeting autophagy for the treatment of cancer

(2018) Simone Fulda   BIOLOGICAL CHEMISTRY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma

(2018) Christopher M Dower et al.   MOLECULAR CANCER THERAPEUTICS

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

(2018) The Duy Nguyen et al.   BLOOD

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

Integrating macromolecular X-ray diffraction data with the graphical user interface iMosflm

(2017) Harold R Powell et al.   Nature Protocols

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Tools for ligand validation inCoot

(2017) Paul Emsley   Acta Crystallographica Section D-Structural Biology

Structure and function of the ULK1 complex in autophagy

(2016) Mary G Lin et al.   CURRENT OPINION IN CELL BIOLOGY

Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells

(2016) Young Hwan Kim et al.   FEBS LETTERS

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

(2016) Terytty Yang Li et al.   MOLECULAR CELL

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

(2015) Michael B. Lazarus et al.   ACS Chemical Biology

Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1

(2015) Michael B. Lazarus et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Atg1 function and regulation

(2014) Edmond Y. Chan et al.   Autophagy

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

(2014) Khandakar A.S.M. Saadat et al.   FEBS Open Bio

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Distinct functions ofUlk1andUlk2in the regulation of lipid metabolism in adipocytes

(2013) Seung-Hyun Ro et al.   Autophagy

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

(2013) Fiona McAlpine et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagic Processes in Yeast: Mechanism, Machinery and Regulation

(2013) F. Reggiori et al.   GENETICS

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

(2012) Luke R. G. Pike et al.   BIOCHEMICAL JOURNAL

Association Analysis ofULK1with Crohn’s Disease in a New Zealand Population

(2012) Angharad R. Morgan et al.   Gastroenterology Research and Practice

The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy

(2011) Eun-Ju Lee et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

(2011) H. Cheong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE