Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics

Overcoming the legal and regulatory barriers to drug repurposing

(2018) Alasdair Breckenridge et al.   NATURE REVIEWS DRUG DISCOVERY

Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon

(2018) Michael P. Pollastri   TRENDS IN PARASITOLOGY

Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

(2018) Lucas N. Alberca et al.   Frontiers in Cellular and Infection Microbiology

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer

(2016) M. R. Jones et al.   ANNALS OF ONCOLOGY

Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective

(2016) Leonardo G. Ferreira et al.   DRUG DISCOVERY TODAY

Drug combination therapy increases successful drug repositioning

(2016) Wei Sun et al.   DRUG DISCOVERY TODAY

Computational and Practical Aspects of Drug Repositioning

(2015) Tudor I. Oprea et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir

(2015) Carolina L. Bellera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Methods of integrating data to uncover genotype–phenotype interactions

(2015) Marylyn D. Ritchie et al.   NATURE REVIEWS GENETICS

Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes

(2015) Melissa L. Sykes et al.   International Journal for Parasitology-Drugs and Drug Resistance

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

(2014) Joseph D. Planer et al.   PLoS Neglected Tropical Diseases

Open-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases

(2013) Minna Allarakhia   Drug Design Development and Therapy

Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo

(2012) Emilie Alirol et al.   CLINICAL INFECTIOUS DISEASES

NCATS launches drug repurposing program

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

(2010) J. C. Engel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Two approaches to discovering and developing new drugs for Chagas disease

(2009) JH McKerrow et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ