Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells

Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

(2018) Mireia Nàger et al.   Autophagy

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

(2018) Chung-Ching Chio et al.   BMC CANCER

The Role of Wnt Signal in Glioblastoma Development and Progression: A Possible New Pharmacological Target for the Therapy of This Tumor

(2018) Mariachiara Zuccarini et al.   Genes

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide

(2018) Tor‐Christian Johannessen et al.   INTERNATIONAL JOURNAL OF CANCER

β-catenin promotes intracellular bacterial killing via suppression of Pseudomonas aeruginosa-triggered macrophage autophagy

(2017) Qiang Fu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Expression profile and clinical significance of Wnt signaling in human gliomas

(2017) Hao Zhang et al.   Oncology Letters

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

(2017) Claudia R. Oliva et al.   Oncotarget

Sorafenib induces autophagic cell death and apoptosis in hepatic stellate cell through the JNK and Akt signaling pathways

(2016) Huiyao Hao et al.   ANTI-CANCER DRUGS

Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP 3 R

(2016) Seokmin Kang et al.   MOLECULAR CANCER THERAPEUTICS

Thioridazine elicits potent antitumor effects in colorectal cancer stem cells

(2016) Chen Zhang et al.   ONCOLOGY REPORTS

Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine

(2016) Haiying Yue et al.   Biomed Research International

Bcl2L12 with a BH3-like domain in regulating apoptosis and TMZ-induced autophagy: A prospective combination of ABT-737 and TMZ for treating glioma

(2015) MING-CHANG YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

(2015) H-W Cheng et al.   Cell Death & Disease

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

(2014) Jayne Loughery et al.   NUCLEIC ACIDS RESEARCH

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells

(2013) Y-B Zhang et al.   Cell Death & Disease

Hyperactivation of the Mammalian Degenerin MDEG Promotes Caspase-8 Activation and Apoptosis

(2012) Ji-An Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

(2012) Katie O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Autophagic degradation of active caspase-8

(2010) Wen Hou et al.   Autophagy

Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition

(2010) Wen-bin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scale to Predict Survival After Surgery for Recurrent Glioblastoma Multiforme

(2010) John K. Park et al.   JOURNAL OF CLINICAL ONCOLOGY

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Intracellular protein degradation in mammalian cells: recent developments

(2009) Erwin Knecht et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway

(2009) M Flahaut et al.   ONCOGENE

G-Protein-Coupled Receptors: From Classical Modes of Modulation to Allosteric Mechanisms

(2008) Thomas M. Bridges et al.   ACS Chemical Biology

Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

(2008) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE