Article
Fisheries
Wen-Hao Zhou, Chen-Chen Wu, Samwel M. Limbu, Rui-Xin Li, Li-Qiao Chen, Fang Qiao, Yuan Luo, Mei-Ling Zhang, Tao Han, Zhen-Yu Du
Summary: This study investigated the effects of different dietary carbohydrate complexities on fish metabolism and liver health in Nile tilapia. The results showed that Nile tilapia utilizes polysaccharides and disaccharides better than monosaccharides, and feeding on monosaccharides causes insulin resistance and glucose metabolism disorders.
Article
Biochemistry & Molecular Biology
Dana Krauss, Ourania Fari, Maria Sibilia
Summary: Colorectal cancer remains one of the deadliest cancer types globally, with increasing incidence in young adolescents. Lipid metabolism plays a crucial role in carcinogenesis, but the detailed mechanisms are not fully understood. This review summarizes the role of lipid metabolism in colorectal cancer and discusses its impact on tumor aggressiveness, patient prognosis, and the tumor microenvironment.
Review
Biochemistry & Molecular Biology
Juan Miguel Godoy-Corchuelo, Luis C. Fernandez-Beltran, Zeinab Ali, Maria J. Gil-Moreno, Juan I. Lopez-Carbonero, Antonio Guerrero-Sola, Angelica Larrad-Sainz, Jorge Matias-Guiu, Jordi A. Matias-Guiu, Thomas J. Cunningham, Silvia Corrochano
Summary: Studies indicate that there is a connection between systemic lipid metabolism alterations and neurodegenerative disorders like ALS and FTD, however, research in this area is still lacking. Many patients have mixed forms of ALS and FTD, leading to a variety of disease presentations.
Review
Biochemistry & Molecular Biology
Chang Guo, Chenxi Wang, Xia Deng, Jianqiang He, Ling Yang, Guoyue Yuan
Summary: ANGPTL8 is significantly increased in type 2 diabetes mellitus, obesity, and metabolic syndrome, serving as a biomarker for these metabolic disorders. It plays a crucial role in lipid metabolism and insulin sensitivity but has conflicting effects on TG uptake in peripheral tissues.
Article
Physiology
Atefeh Berenjian, Mohammad Reza Bakhtiarizadeh, Abdollah Mohammadi-Sangcheshmeh, Seyed Davood Sharifi
Summary: Supplementing with ?-3 fatty acids can reduce the harmful effects of stress. This study used RNA-sequencing technology to analyze the liver transcriptome of laying hens fed a diet supplemented with ?-3, revealing different gene expression profiles and potential pathways involved in response to stress. The results showed that the differentially expressed genes were enriched in processes such as steroid and cholesterol biosynthesis, fatty acid metabolism, AMPK signaling pathway, fatty acid biosynthesis, and immune response. Downregulation of UNC13B and ADRA1B genes in the stress_?-3 group may play a role in facilitating the response to stress. This study enhances our understanding of the molecular responses to stress in laying hens fed a diet supplemented with ?-3 fatty acids.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jorge Felipe Argenta Model, Matheus Vieira Lima, Renata Ohlweiler, Elaine Sarapio, Everton Lopes Vogt, Debora Santos Rocha, Samir Khal de Souza, Anapaula Sommer Vinagre
Summary: The study found that liraglutide can attenuate metabolic changes induced by orchiectomy in rats, including reducing triglyceridemia and improving glucose metabolism. This suggests that liraglutide may be a promising therapeutic strategy to address disruptions in energy metabolism caused by androgen deficiency.
Article
Pharmacology & Pharmacy
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
Summary: Cancer disrupts lipid metabolism, leading to altered metabolism intermediates and contributing to abnormal growth and metastasis. The shift in lipid metabolism towards an increased presence of polyunsaturated fatty acids (PUFAs) in membrane phospholipids (PLs) also causes resistance to cancer therapy. The vulnerability of cancer cells to lipid peroxidation (LPO) and subsequent ferroptosis, a new form of regulated cell death, depends on adaptive lipidome remodeling, LPO patterns, and LPO scavenging ability. Understanding the molecular basis of altered lipid metabolism in cancer may offer new opportunities for overcoming cancer resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Rika Shikida, Minji Kim, Makoto Futohashi, Koki Nishihara, Huseong Lee, Yutaka Suzuki, Yeolchang Baek, Tatsunori Masaki, Kentaro Ikuta, Eiji Iwamoto, Yoshinobu Uemoto, Satoshi Haga, Fuminori Terada, Sanggun Roh
Summary: This study aimed to reveal the physiological roles of hepatic ANGPTL3 in Japanese Black steers during the fattening period and investigate the regulatory effects of hepatic ANGPTL3. The results showed that relative ANGPTL3 mRNA expression decreased as fattening progressed, and it was negatively correlated with blood triglyceride concentrations. Furthermore, in cultured bovine hepatocytes, the relative mRNA expression of ANGPTL3 was downregulated in oleate treatment. These findings suggest that ANGPTL3 plays a role in lipid metabolism during the fattening period.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Cell Biology
Ruixue Yang, Mei Yi, Bo Xiang
Summary: Chemotherapy is an important treatment for cancer, but drug resistance is a major obstacle. Aberrant lipid metabolism is closely related to drug resistance, and novel therapeutic strategies targeting lipid metabolism show promise in overcoming resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Ailin Liu, Zhixia Xiao, Zhili Wang, Hon-Ming Lam, Mee-Len Chye
Summary: The study found that short-term salt stress caused dynamic changes in lipids in soybean leaves, including the recycling of phospholipids and galactolipids. Proteins involved in phospholipid synthesis were upregulated, and salt stress enhanced the biosynthesis of jasmonic acid and phosphatidylinositol.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Environmental Sciences
Chunmei Wu, Xiaoqian Zhang, Zhenhao Cui, Jinhao Gou, Bo Zhang, Xue Sun, Nianjun Xu
Summary: High temperatures have a negative impact on the growth and productivity of Gracilariopsis lemaneiformis. In this study, the researchers discovered that patatin-like phospholipase A (pPLA) plays a crucial role in the stress response of G. lemaneiformis. By inhibiting the activity of pPLA, the sensitivity of G. lemaneiformis to heat stress increased, leading to decreased biomass and photosystem II activity. Moreover, the inhibition of pPLA resulted in alterations in lipid metabolism and the biosynthesis of jasmonic acid (JA). This research provides new insights into the heat stress adaptation mechanism of G. lemaneiformis.
MARINE ENVIRONMENTAL RESEARCH
(2022)
Article
Physiology
Yingjiang Xu, Huan Liu, Dianfeng Han, Lihua Ren, Xianghong Gong, Fang Jiang, Yanmei Cui, Xiaojing Liu, Chuanbo Ren, Jinglin Xue, Xiuhui Tian
Summary: The study revealed that the metabolic changes in the digestive system of mantis shrimp under Cd stress, with 91 metabolites differentially expressed mainly in amino acids, phospholipids, and fatty acid esters. The functional pathways of differential metabolites showed significant effects on biological processes such as amino acid metabolism, transmembrane transport, energy metabolism, and signal transduction. The Cd-induced oxidative stress and energy metabolism disorders were characterized by the differential expression of amino acids and ADP in mantis shrimp, while the interference of transmembrane transport and signal transduction was due to the differential expression of phospholipids.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Shoko Takahashi, Kenji Saito, Xuguang Li, Huijuan Jia, Hisanori Kato
Summary: This study found that chlorogenic acid enhances energy metabolism, including the TCA cycle, the glycolytic system, electron transport, and ATP synthesis. These findings contribute to our understanding of the beneficial effects of coffee consumption.
Review
Endocrinology & Metabolism
Ping Ling, Xueying Zheng, Sihui Luo, Junbo Ge, Suowen Xu, Jianping Weng
Summary: ASCVD is the largest cause of morbidity and mortality worldwide, with lipid-lowering therapies as the current major cornerstone of its management. However, some patients do not respond to standard therapies and remain at high risk of ASCVD.
DIABETES OBESITY & METABOLISM
(2021)
Article
Environmental Sciences
Robert B. Hood, Donghai Liang, Yu-Han Chiu, Helena Sandoval-Insausti, Jorge E. Chavarro, Dean Jones, Russ Hauser, Audrey J. Gaskins
Summary: This study utilized metabolomics to analyze the alterations in the serum metabolome associated with high and low pesticide residue intake from fruits and vegetables. The findings suggest that there are different metabolic pathways associated with high and low pesticide residue FV intake, supporting the disparate health effects associated with these exposures.
ENVIRONMENT INTERNATIONAL
(2022)
Correction
Biochemistry & Molecular Biology
Therese Seidlitz, Bon-Kyoung Koo, Daniel E. Stange
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Gastroenterology & Hepatology
Dylan Liabeuf, Masanobu Oshima, Daniel E. Stange, Michael Sigal
Summary: Environmental factors, such as Helicobacter pylori, along with genetic factors, increase the risk of gastric cancer. Advances in technology have allowed researchers to uncover the alterations in pathways, including mutations and epigenetic changes, that contribute to gastric cancer development. Understanding the behavior of gastric stem cells and how H. pylori interacts with them has provided insights into the process of carcinogenesis. Furthermore, the use of reporter mice and human tissue organoids has led to a better understanding of the signals and mutations associated with different types of gastric cancer.
Review
Clinical Neurology
Andia Mirbagheri, Nima Etminan, Sebastian Schoelch, Christopher Maier, Jason Perrin, Frederik Enders
Summary: This article discusses an atypical abdominal disease that mimics spinal diseases and presents a rare case of a patient with lower back pain who was ultimately diagnosed with cholecystitis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Oncology
Mohammad Alwahsh, Robert Knitsch, Rosemarie Marchan, Joerg Lambert, Christian Hoerner, Xiaonan Zhang, Berthold Schalke, De-Hyung Lee, Elena Bulut, Thomas Graeter, German Ott, Katrin S. Kurz, Gerhard Preissler, Sebastian Schoelch, Joviana Farhat, Zhihan Yao, Carsten Sticht, Philipp Stroebel, Roland Hergenroeder, Alexander Marx, Djeda Belharazem
Summary: This study is the first metabolomics investigation on thymic epithelial tumors, which identified differential metabolic profiles among different subtypes and predicted activated metabolic pathways. These findings provide new insights for the treatment of aggressive thymomas and thymic carcinomas.
Review
Oncology
Jianxin Tao, Lei Zhu, Mina Yakoub, Christoph Reissfelder, Sonja Loges, Sebastian Schoelch
Article
Immunology
Corinne Huebers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schoelch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut G. Augustin, Moritz Felcht
Summary: The study identified proteolytically cleaved fragments of ANGPTL4 as active contributors to the communication between primary tumors and distant site metastases, with implications for tumor progression and antimetastatic therapy. nANGPTL4 in tumor patients may serve as a novel biomarker for tumor progression and anti-metastasis therapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Kristin Pape, Anna J. Loessner, Doreen William, Tabea Czempiel, Elke Beyreuther, Anna Klimova, Claudia Lehmann, Tim Schmaeche, Sebastian R. Merker, Max Naumann, Anne-Marlen Ada, Franziska Baenke, Therese Seidlitz, Rebecca Buetof, Antje Dietrich, Mechthild Krause, Jurgen Weitz, Barbara Klink, Claere von Neubeck, Daniel E. Stange
Summary: Radiation therapy plays a crucial role in the treatment of colorectal cancer, but some patients are resistant to this treatment. In this study, patient-derived organoids were used to investigate the mechanisms of radioresistance and potential strategies to overcome it.
Article
Oncology
Felix Merboth, Heiner Nebelung, Natalie Wotschel, Hendrik Liebscher, Franziska Eckert, Janusz von Renesse, Jasmin Hasanovic, Thilo Welsch, Johannes Fritzmann, Daniel E. Stange, Verena Plodeck, Ralf-Thorsten Hoffmann, Marius Distler, Juergen Weitz, Johanna Kirchberg
Summary: This study found that robot-assisted minimally invasive esophagectomy (RAMIE) is associated with a lower risk of developing sarcopenia after surgery compared to open esophagectomy (OE) for esophageal cancer. These findings provide new evidence to support the use of robotic surgery in the multimodal therapy of EC.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Engineering, Biomedical
Verena Kast, Ali Nadernezhad, Dagmar Pette, Anastasiia Gabrielyan, Maximilian Fusenig, Kim C. Honselmann, Daniel E. Stange, Carsten Werner, Daniela Loessner
Summary: Pancreatic cancer is a devastating malignancy with limited treatment options. The tumor microenvironment, containing excessive extracellular matrix and stromal cells, acts as a barrier to drug delivery and contributes to therapy resistance and disease progression. To overcome this limitation, a multicellular 3D cancer model is developed to mimic key components of tumor tissues and assess responses to immunotherapy. Combining the CD11b agonist ADH-503 with anti-PD-1 immunotherapy and chemotherapy shows significant reduction in tumor cell viability, proliferation, metabolic activity, immunomodulation, and secretion of immunosuppressive and tumor growth-promoting cytokines.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Respiratory System
Fukang Jin, Lei Zhu, Jingbo Shao, Mina Yakoub, Lukas Schmitt, Christoph ReiBfelder, Sonja Loges, Axel Benner, Sebastian Scholch
Summary: This study conducted a comprehensive meta-analysis to assess the prognostic value of circulating tumor cells (CTCs) in different histological types of lung cancer. The results showed that CTC detection indicates poor prognosis, particularly in small cell lung cancer (SCLC) patients. Epithelial CTCs predict a worse outcome for lung cancer compared to mesenchymal CTCs or epithelial-mesenchymal hybrids.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Biochemistry & Molecular Biology
Sonia Wagner, Marta Gomez de Cedron, Joaquin Navarro del Hierro, Diego Martin-Hernandez, Maria de las Nieves Siles, Susana Santoyo, Laura Jaime, Diana Martin, Tiziana Fornari, Ana Ramirez de Molina
Summary: Synsepalum dulcificum, also known as miracle berry, is a berry fruit from West Africa that can convert sour taste to sweet taste. It is rich in terpenoids and phenolic compounds, which contribute to its antioxidant activity. Supercritical extracts from the seed show potential in inhibiting colorectal cancer cell bioenergetics, possibly through the inhibition of key drivers of de novo lipogenesis. Further research is needed to explore the potential of these extracts as co-adjuvants in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fukang Jin, Zhiguang Yang, Jingbo Shao, Jianxin Tao, Christoph Reissfelder, Sonja Loges, Lei Zhu, Sebastian Schoelch
Summary: Mutations in the ARID1A gene are frequently found in various human cancers, including lung cancer. ARID1A loss is associated with poor prognosis and clinicopathological characteristics in lung cancer. Co-mutation of ARID1A and EGFR affects the efficacy of EGFR-TKIs but increases the clinical benefit of ICIs.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Chemistry, Physical
Jovan Mircetic, Aylin Camgoez, Moustafa Abohawya, Li Ding, Julia Dietzel, Sebastian Garcia Tobar, Maciej Paszkowski-Rogacz, Therese Seidlitz, Tim Schmaeche, Marie-Christin Mehnert, Olga Sidorova, Juergen Weitz, Frank Buchholz, Daniel E. Stange
Summary: Viability CRISPR screens have been successfully applied in studying genome function, but the application in patient-derived organoids (PDOs) has been slow. In this study, a negative selection CRISPR screen in GC PDOs identified KDM1A as a marker for gastric cancer vulnerability, and the inhibition of KDM1A resulted in cell cycle arrest. Additionally, upregulation of NDRG1 predicted response to KDM1Ai with high sensitivity and specificity.
Meeting Abstract
Oncology
Melanie Janning, Martin Ziegler, Corinna Albers-Leischner, Lorena Salgueiro, Christina Alidousty, Felix C. Saalfeld, Sebastian Merker, Carina Wenzel, Daniel Stange, Juergen Wolf, Reinhard Buettner, Christian Brandts, Martin Wermke, Sonja Loges
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Surgery
Jan-Hendrik Egberts, Thilo Welsch, Felix Merboth, Sandra Korn, Christian Praetorius, Daniel E. Stange, Marius Distler, Matthias Biebl, Johann Pratschke, Felix Nickel, Beat Mueller-Stich, Daniel Perez, Jakob R. Izbicki, Thomas Becker, Juergen Weitz
Summary: This study reports the results of robotic-assisted minimally invasive esophagectomy (RAMIE) for the treatment of esophageal tumors. The results show that RAMIE is a safe procedure with acceptable outcomes in a multicenter setting. The learning curve is relatively low.
LANGENBECKS ARCHIVES OF SURGERY
(2022)