Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133

Lipopolysaccharide supports maintaining the stemness of CD133+ hepatoma cells through activation of the NF-κB/HIF-1α pathway

(2016) Fo-Bao Lai et al.   CANCER LETTERS

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Reconstruction of genome-scale human metabolic models using omics data

(2015) Jae Yong Ryu et al.   Integrative Biology

Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

(2015) Glenn Simmons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of ETA Receptor by Endothelin-1 Induces Hepatocellular Carcinoma Cell Migration and Invasion via ERK1/2 and AKT Signaling Pathways

(2015) Ning Cong et al.   JOURNAL OF MEMBRANE BIOLOGY

OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease

(2015) Thomas E. Akie et al.   PLoS One

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling

(2014) R. Agren et al.   Molecular Systems Biology

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Overexpression of Endothelin 1 Triggers Hepatocarcinogenesis in Zebrafish and Promotes Cell Proliferation and Migration through the AKT Pathway

(2014) Jeng-Wei Lu et al.   PLoS One

The Transcriptional Profiling of Glycogenes Associated with Hepatocellular Carcinoma Metastasis

(2014) Tianhua Liu et al.   PLoS One

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

COBRApy: COnstraints-Based Reconstruction and Analysis for Python

(2013) Ali Ebrahim et al.   BMC Systems Biology

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Cancer stem cells in the development of liver cancer

(2013) Taro Yamashita et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth

(2013) C. Bull et al.   MOLECULAR CANCER THERAPEUTICS

The RAVEN Toolbox and Its Use for Generating a Genome-scale Metabolic Model for Penicillium chrysogenum

(2013) Rasmus Agren et al.   PLoS Computational Biology

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas

(2012) Kyu Yun Jang et al.   PLoS One

CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma

(2011) Lian Shu Piao et al.   CANCER LETTERS

The PPAR-RXR Transcriptional Complex in the Vasculature

(2011) Jorge Plutzky   CIRCULATION RESEARCH

CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling

(2011) Kwan Ho Tang et al.   HEPATOLOGY

Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies

(2011) Jens U. Marquardt et al.   JOURNAL OF HEPATOLOGY

Role of cancer stem cells in hepatocarcinogenesis

(2011) Bo Wang et al.   Genome Medicine

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications

(2010) J.U. Marquardt et al.   JOURNAL OF HEPATOLOGY

Expander: from expression microarrays to networks and functions

(2010) Igor Ulitsky et al.   Nature Protocols

Hepatocellular Carcinoma: Epidemiology, Surveillance, and Diagnosis

(2010) Morris Sherman   SEMINARS IN LIVER DISEASE

Current Management of Hepatocellular Cancer

(2010) Bernardino Rampone et al.   Current Oncology Reports

Cancer stem cells and their niche

(2009) Hiroko Iwasaki et al.   CANCER SCIENCE

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome

(2009) M. Schreurs et al.   Obesity Reviews

GrowMatch: An Automated Method for Reconciling In Silico/In Vivo Growth Predictions

(2009) Vinay Satish Kumar et al.   PLoS Computational Biology

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA