Targeting Myeloid-Derived Suppressor Cells in Cancer Immunotherapy

Myeloid-derived suppressor cells impede T cell functionality and promote Th17 differentiation in oral squamous cell carcinoma

(2020) Asif A. Dar et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid-derived suppressor cells—new and exciting players in lung cancer

(2020) Zhenzhen Yang et al.   Journal of Hematology & Oncology

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

(2020) Zhihao Lu et al.   NATURE

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

(2020) Andrew M. K. Law et al.   Cells

LXR activation radiosensitizes non-small cell lung cancer by restricting myeloid-derived suppressor cells

(2020) Huaizhen Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4+ T-cell differentiation

(2020) Lin Dong et al.   Cellular & Molecular Immunology

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

(2020) Eslam Mohamed et al.   IMMUNITY

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Targeting Myeloid-Derived Suppressor Cell, a Promising Strategy to Overcome Resistance to Immune Checkpoint Inhibitors

(2020) Aohan Hou et al.   Frontiers in Immunology

Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells

(2020) Zhengguo Zhang et al.   Cancers

Metabolic Regulation of Myeloid-Derived Suppressor Cell Function in Cancer

(2020) Yufei Wang et al.   Cells

Friend or Foe? Recent Strategies to Target Myeloid Cells in Cancer

(2020) Mehdi Chaib et al.   Frontiers in Cell and Developmental Biology

CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent

(2020) Jingzhe Wang et al.   PHARMACOLOGICAL RESEARCH

Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

(2019) Claudia Maletzki et al.   Journal for ImmunoTherapy of Cancer

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

(2019) Sunil Singhal et al.   Science Translational Medicine

The mechanistic study behind suppression of GVHD while retaining GVL activities by myeloid-derived suppressor cells

(2019) Jilu Zhang et al.   LEUKEMIA

IDO1 Inhibition Overcomes Radiation-Induced “Rebound Immune Suppression” by Reducing Numbers of IDO1-Expressing Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2019) Ailin Li et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

EZH2 inhibitor GSK126 suppresses anti-tumor immunity by driving production of myeloid-derived suppressor cells

(2019) Shuo Huang et al.   CANCER RESEARCH

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

(2019) Wenting Liao et al.   CANCER CELL

Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

(2019) Yuan Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma

(2019) Man Liu et al.   GUT

Fatty acid transport protein 2 reprograms neutrophils in cancer

(2019) Filippo Veglia et al.   NATURE

Role of myeloid-derived suppressor cells in immune checkpoint inhibitor therapy in cancer

(2019) Su-Myeong Park et al.   ARCHIVES OF PHARMACAL RESEARCH

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy

(2019) Magdalena Jarosz-Biej et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment

(2019) Adélie Dumont et al.   Cell Death & Disease

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

(2019) Jie Zhou et al.   Nature Communications

Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity

(2019) Graham Pawelec et al.   Frontiers in Immunology

The role of the P2X7 receptor in myeloid-derived suppressor cells and immunosuppression

(2019) Elisa Principi et al.   CURRENT OPINION IN PHARMACOLOGY

Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer

(2019) Asha Jayakumar et al.   JOURNAL OF IMMUNOLOGY

Combination treatment of the oral CHK1 inhibitor, SRA737 and low dose gemcitabine, enhances the effect of PD-L1 blockade by modulating the immune microenvironment in small cell lung cancer.

(2019) Triparna Sen et al.   Journal of Thoracic Oncology

The multifaceted immune regulation of bladder cancer

(2019) Anna K. Schneider et al.   Nature Reviews Urology

TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma

(2019) Alisha Holtzhausen et al.   Cancer Immunology Research

Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

(2019) Rosalinda Trovato et al.   Journal for ImmunoTherapy of Cancer

MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers

(2019) Livingstone Fultang et al.   EBioMedicine

Myeloid-derived suppressor cells in hematological malignancies: friends or foes

(2019) Meng Lv et al.   Journal of Hematology & Oncology

Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches

(2019) Anita Thyagarajan et al.   Cancers

Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells

(2019) Cong Hu et al.   BRITISH JOURNAL OF CANCER

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

(2019) Sarah Greene et al.   CLINICAL CANCER RESEARCH

Combining epigenetic and immune therapy to overcome cancer resistance

(2019) Stephanie Gomez et al.   SEMINARS IN CANCER BIOLOGY

1α, 25 Dihydroxyvitamin D (1,25(OH)2D) inhibits the T cell suppressive function of myeloid derived suppressor cells (MDSC)

(2019) J.C. Fleet et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice

(2018) Di Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor-infiltrating Treg, MDSC, and IDO expression associated with outcomes of neoadjuvant chemotherapy of breast cancer

(2018) Fangxuan Li et al.   CANCER BIOLOGY & THERAPY

Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapy

(2018) Raimund Bauer et al.   CANCER RESEARCH

A RIPK3-PGE2 circuit mediates myeloid-derived suppressor cell-potentiated colorectal carcinogenesis

(2018) Guifang Yan et al.   CANCER RESEARCH

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

Clinical relevance and suppressive capacity of human MDSC subsets

(2018) Stephan Lang et al.   CLINICAL CANCER RESEARCH

Myeloid derived-suppressor cells: their role in cancer and obesity

(2018) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN IMMUNOLOGY

Myeloid-derived suppressor cell: Roles in the tumor microenvironment and tumor radiotherapy

(2018) Zhongnan Yin et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity

(2018) Yu-Lin Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Myeloid-derived Suppressor Cells and Programmed Death Ligand 1 Confers Therapeutic Advantage of Ablative Hypofractionated Radiation Therapy Compared With Conventional Fractionated Radiation Therapy

(2018) Jie Lan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Next generation of immune checkpoint therapy in cancer: new developments and challenges

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5

(2018) Yong Wang et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

The receptor for advanced glycation end products: A fuel to pancreatic cancer

(2018) Uzma Shahab et al.   SEMINARS IN CANCER BIOLOGY

Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

(2018) Jie Zhou et al.   SEMINARS IN IMMUNOLOGY

Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms

(2018) Dmitri Negorev et al.   Scientific Reports

Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23

(2018) Juming Yan et al.   Cancer Immunology Research

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity

(2018) Lee-Hwa Tai et al.   OncoImmunology

VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML

(2018) Liru Wang et al.   OncoImmunology

Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab

(2018) Richard P. Tobin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Myeloid-Derived Suppressor Cells as a Regulator of Immunity in Organ Transplantation

(2018) Tsukasa Nakamura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging strategies for combination checkpoint modulators in cancer immunotherapy

(2018) Aleksandra Popovic et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

(2018) Arianna Calcinotto et al.   NATURE

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells

(2018) Prajna Guha et al.   ONCOGENE

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

(2018) Christopher Groth et al.   BRITISH JOURNAL OF CANCER

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers

(2018) Dayson Moreira et al.   CLINICAL CANCER RESEARCH

Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis

(2018) Arturo Navarro-Martín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma

(2018) Su Jong Yu et al.   JOURNAL OF HEPATOLOGY

MDSC; the Most Important Cell You Have Never Heard Of

(2018) R.J. Tesi   TRENDS IN PHARMACOLOGICAL SCIENCES

The Yin and Yang of Myeloid Derived Suppressor Cells

(2018) Snehil Budhwar et al.   Frontiers in Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

(2018) Matthew J. Reilley et al.   Journal for ImmunoTherapy of Cancer

Metabolic pathways of L-arginine and therapeutic consequences in tumors

(2018) Jarosław Szefel et al.   Advances in Medical Sciences

CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children’s Oncology Group Trial AAML0531

(2017) Jatinder K. Lamba et al.   JOURNAL OF CLINICAL ONCOLOGY

Potential contribution of tumor-associated slan + cells as anti-CSF-1R targets in human carcinoma

(2017) Silvia Lonardi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology

(2017) Antonio Sica et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combined Radiotherapy and Anti–PD-L1 Antibody Synergistically Enhances Antitumor Effect in Non–Small Cell Lung Cancer

(2017) Xiaomei Gong et al.   Journal of Thoracic Oncology

Neutrophils in cancer: prognostic role and therapeutic strategies

(2017) Alberto Ocana et al.   Molecular Cancer

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

(2017) Meredith L. Stone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

(2017) Ben Creelan et al.   OncoTargets and Therapy

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

(2017) Hua Liang et al.   Nature Communications

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination

(2017) Annkristin Heine et al.   OncoImmunology

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

(2017) Chiara Secondini et al.   OncoImmunology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

MDSCs in cancer: Conceiving new prognostic and therapeutic targets

(2016) Francesco De Sanctis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

(2016) Niels Halama et al.   CANCER CELL

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner

(2016) Xia Xu et al.   Cellular & Molecular Immunology

Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma

(2016) Y. Mao et al.   CLINICAL CANCER RESEARCH

Inflammation-induced myeloid-derived suppressor cells associated with squamous cell carcinoma of the head and neck

(2016) Wen-Cheng Chen et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

(2016) Emma Eriksson et al.   Journal of Translational Medicine

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Tumor Cell–Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells

(2016) Nikolaos Svoronos et al.   Cancer Discovery

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

(2016) Amy W Ku et al.   eLife

Synergistic COX2 Induction by IFN  and TNF  Self-Limits Type-1 Immunity in the Human Tumor Microenvironment

(2016) J. L. Wong et al.   Cancer Immunology Research

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy

(2016) Rikke B. Holmgaard et al.   OncoImmunology

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

(2016) Rikke B. Holmgaard et al.   EBioMedicine

Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy

(2015) H.-M. Chen et al.   CLINICAL CANCER RESEARCH

Norepinephrine-induced myeloid-derived suppressor cells block T-cell responsesviageneration of reactive oxygen species

(2015) Yufeng Liu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity

(2015) C. Cimen Bozkus et al.   JOURNAL OF IMMUNOLOGY

1 ,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling

(2015) P.-T. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Myeloid Lineage-Specific Deletion of Antioxidant System Enhances Tumor Metastasis

(2014) K. Hiramoto et al.   Cancer Prevention Research

VISTA Regulates the Development of Protective Antitumor Immunity

(2014) I. Le Mercier et al.   CANCER RESEARCH

Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma

(2014) D. T. Weed et al.   CLINICAL CANCER RESEARCH

Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

(2014) Y. Mao et al.   CLINICAL CANCER RESEARCH

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors

(2014) Daniel W. Beury et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Calcineurin-NFAT Axis Controls Allograft Immunity in Myeloid-Derived Suppressor Cells through Reprogramming T Cell Differentiation

(2014) Xiao Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Targeting Immune Suppression with PDE5 Inhibition in End-Stage Multiple Myeloma

(2014) K. A. Noonan et al.   Cancer Immunology Research

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis

(2013) G. Liu et al.   CANCER RESEARCH

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

(2013) David Vasquez-Dunddel et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

(2013) Je-In Youn et al.   NATURE IMMUNOLOGY

Myeloid-Derived Suppressor Cells Attenuate TH1 Development through IL-6 Production to Promote Tumor Progression

(2013) H. Tsukamoto et al.   Cancer Immunology Research

CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells

(2012) M. Velasco-Velazquez et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

On the armament and appearances of human myeloid-derived suppressor cells

(2012) Isabel Poschke et al.   CLINICAL IMMUNOLOGY

CD8+ T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer

(2012) Yuan Zhuang et al.   GASTROENTEROLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development

(2012) Courtney Smith et al.   Cancer Discovery

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

(2011) M. Fujita et al.   CANCER RESEARCH

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents

(2010) Xueping Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell-Dependent Antitumor Immunity

(2010) J. Vincent et al.   CANCER RESEARCH

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

A Novel Chemoimmunomodulating Property of Docetaxel: Suppression of Myeloid-Derived Suppressor Cells in Tumor Bearers

(2010) K. N. Kodumudi et al.   CLINICAL CANCER RESEARCH

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Up-regulated myeloid-derived suppressor cell contributes to hepatocellular carcinoma development by impairing dendritic cell function

(2010) Cheng-En Hu et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

(2009) P.-Y. Pan et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

(2009) E. M. Hanson et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

(2008) P. Serafini et al.   CANCER RESEARCH

Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression

(2008) S. Peter Bak et al.   MOLECULAR IMMUNOLOGY