Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance

The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome

(2020) Elisa D’Arcangelo et al.   BRITISH JOURNAL OF CANCER

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

(2020) Samarth Hegde et al.   CANCER CELL

Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy

(2020) Tiffany C. Blair et al.   JOURNAL OF IMMUNOLOGY

The role of regulatory T cells in the response to radiation therapy in head and neck cancer

(2019) Ayman J Oweida et al.   JNCI-Journal of the National Cancer Institute

ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment

(2019) Magnus T. Dillon et al.   CLINICAL CANCER RESEARCH

Inhibition of EphB4-ephrin-B2 signaling reprograms the tumor immune microenvironment in head and neck cancers

(2019) Shilpa Bhatia et al.   CANCER RESEARCH

Cancer-associated fibroblasts in radiotherapy: challenges and new opportunities

(2019) Zhanhuai Wang et al.   Cell Communication and Signaling

Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken

(2019) M.-C. Vozenin et al.   CLINICAL ONCOLOGY

Assessing the interactions between radiotherapy and antitumour immunity

(2019) Clemens Grassberger et al.   Nature Reviews Clinical Oncology

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

(2019) Roheena Z. Panni et al.   Science Translational Medicine

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Neutrophils promote tumor resistance to radiation therapy

(2019) Amy J. Wisdom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

Safety of combining radiotherapy with immune-checkpoint inhibition

(2018) William L. Hwang et al.   Nature Reviews Clinical Oncology

Adipocyte biology in breast cancer: From silent bystander to active facilitator

(2018) Junjeong Choi et al.   PROGRESS IN LIPID RESEARCH

The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies

(2018) C. M. van Leeuwen et al.   Radiation Oncology

Cross Talk between Radiation and Immunotherapy: The Twain Shall Meet

(2018) Swaminathan P. Iyer et al.   RADIATION RESEARCH

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

(2018) Silvia C. Formenti et al.   NATURE MEDICINE

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

(2018) Valentina Poltavets et al.   Frontiers in Oncology

Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy

(2017) Guanmin Meng et al.   FASEB JOURNAL

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial

(2017) Anita Mahajan et al.   LANCET ONCOLOGY

Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial

(2017) Narek Shaverdian et al.   LANCET ONCOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Radiotherapy and immunotherapy: a beneficial liaison?

(2017) Ralph R. Weichselbaum et al.   Nature Reviews Clinical Oncology

Stereotactic Body Radiotherapy for Low- and Intermediate-Risk Prostate Cancer

(2017) Amar U. Kishan et al.   SEMINARS IN RADIATION ONCOLOGY

CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma

(2017) Hongfang Zhang et al.   Cell Death & Disease

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors

(2017) Benjamin Frey et al.   Frontiers in Immunology

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

(2017) Yongbin Wang et al.   EBioMedicine

Low doses of gamma irradiation potentially modifies immunosuppressive tumor microenvironment by retuning tumor-associated macrophages: lesson from insulinoma

(2016) Hridayesh Prakash et al.   CARCINOGENESIS

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

(2016) Lena Seifert et al.   GASTROENTEROLOGY

Tolerogenic effect of mouse fibroblasts on dendritic cells

(2016) Mohsen Khosravi-Maharlooei et al.   IMMUNOLOGY

The role of neoantigens in response to immune checkpoint blockade

(2016) Nadeem Riaz et al.   INTERNATIONAL IMMUNOLOGY

Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions

(2016) María de Lourdes Mora-García et al.   Journal of Translational Medicine

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Stereotactic Body Radiation Therapy for Stage I Non–Small Cell Lung Cancer

(2016) Paul Aridgides et al.   Thoracic Surgery Clinics

Impacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment

(2016) Natacha Leroi et al.   Frontiers in Pharmacology

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Current clinical trials testing the combination of immunotherapy with radiotherapy

(2016) Josephine Kang et al.   Journal for ImmunoTherapy of Cancer

M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation

(2016) Makiko Okubo et al.   Scientific Reports

The effect of ionizing radiation on regulatory T cells in health and disease

(2015) Eszter Persa et al.   CANCER LETTERS

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

(2015) Kobe Reynders et al.   CANCER TREATMENT REVIEWS

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions

(2015) A. Filatenkov et al.   CLINICAL CANCER RESEARCH

Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy

(2015) H.-M. Chen et al.   CLINICAL CANCER RESEARCH

Targeting the tumor vasculature to enhance T cell activity

(2015) Evripidis Lanitis et al.   CURRENT OPINION IN IMMUNOLOGY

Radiation-induced fibrosis: mechanisms and implications for therapy

(2015) Jeffrey M. Straub et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

Myeloid-Derived Cells in Tumors: Effects of Radiation

(2015) Ralph E. Vatner et al.   SEMINARS IN RADIATION ONCOLOGY

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy

(2015) Stephen L. Shiao et al.   Cancer Immunology Research

PD-1 Restrains Radiotherapy-Induced Abscopal Effect

(2015) S. S. Park et al.   Cancer Immunology Research

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Cancer-Associated Fibroblasts Connect Metastasis-Promoting Communication in Colorectal Cancer

(2015) Joke Tommelein et al.   Frontiers in Oncology

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

(2014) S. J. Dovedi et al.   CANCER RESEARCH

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability

(2014) Feng Ru Tang et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

(2014) S. Matsumura et al.   JOURNAL OF IMMUNOLOGY

Radiation-Induced IFN-  Production within the Tumor Microenvironment Influences Antitumor Immunity

(2014) A. A. Lugade et al.   JOURNAL OF IMMUNOLOGY

Radiotherapy-Induced Anti-Tumor Immunity Contributes to the Therapeutic Efficacy of Irradiation and Can Be Augmented by CTLA-4 Blockade in a Mouse Model

(2014) Yuya Yoshimoto et al.   PLoS One

Axitinib sensitization of high Single Dose Radiotherapy

(2014) Shyam S. Rao et al.   RADIOTHERAPY AND ONCOLOGY

Contextual regulation of pancreatic cancer stem cell phenotype and radioresistance by pancreatic stellate cells

(2014) Osama Al-Assar et al.   RADIOTHERAPY AND ONCOLOGY

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

(2014) A. B. Sharabi et al.   Cancer Immunology Research

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Radiotherapy and the Tumor Stroma: The Importance of Dose and Fractionation

(2014) Turid Hellevik et al.   Frontiers in Oncology

IFN-γ Mediates the Antitumor Effects of Radiation Therapy in a Murine Colon Tumor

(2013) Scott A. Gerber et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system

(2013) Golam Kibria et al.   ARCHIVES OF PHARMACAL RESEARCH

Vasculogenesis: a crucial player in the resistance of solid tumours to radiotherapy

(2013) J M Brown   BRITISH JOURNAL OF RADIOLOGY

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Understanding the functions of tumor stroma in resistance to ionizing radiation: Emerging targets for pharmacological modulation

(2013) Cyrus Chargari et al.   DRUG RESISTANCE UPDATES

Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors

(2013) Scott A. Gerber et al.   INTERNATIONAL JOURNAL OF CANCER

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

(2013) Paula D. Bos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Hypoxia-Induced Nanog Favors the Intratumoral Infiltration of Regulatory T Cells and Macrophages via Direct Regulation of TGF- 1

(2013) M. Hasmim et al.   JOURNAL OF IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In SituObservation of the Effects of Local Irradiation on Cytotoxic and Regulatory T Lymphocytes in Cervical Cancer Tissue

(2013) Shi Qinfeng et al.   RADIATION RESEARCH

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells

(2013) Satoru Osuka et al.   STEM CELLS

The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment

(2012) Jae Hak Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression

(2012) E. Pazolli et al.   CANCER RESEARCH

Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β

(2012) Matthew E. Hardee et al.   CANCER RESEARCH

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

(2012) M. Shibuya   JOURNAL OF BIOCHEMISTRY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Radiotherapy Promotes Tumor-Specific Effector CD8+ T Cells via Dendritic Cell Activation

(2012) A. Gupta et al.   JOURNAL OF IMMUNOLOGY

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells

(2012) Shan Wan et al.   PLoS One

Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy

(2012) Marka R. Crittenden et al.   PLoS One

Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced

(2012) Turid Hellevik et al.   Radiation Oncology

Radiation-Induced Vascular Damage in Tumors: Implications of Vascular Damage in Ablative Hypofractionated Radiotherapy (SBRT and SRS)

(2012) Heon Joo Park et al.   RADIATION RESEARCH

Regulatory T Cells in Radiotherapeutic Responses

(2012) Dörthe Schaue et al.   Frontiers in Oncology

Immunomodulatory Properties and Molecular Effects in Inflammatory Diseases of Low-Dose X-Irradiation

(2012) Franz Rödel et al.   Frontiers in Oncology

Radiation as an immunological adjuvant: current evidence on dose and fractionation

(2012) Sandra Demaria et al.   Frontiers in Oncology

Irradiation Promotes an M2 Macrophage Phenotype in Tumor Hypoxia

(2012) Chi-Shiun Chiang et al.   Frontiers in Oncology

Cancer-associated adipocytes promotes breast tumor radioresistance

(2011) Ludivine Bochet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through  1-Integrin Signaling

(2011) T. S. Mantoni et al.   CANCER RESEARCH

Maximizing Tumor Immunity With Fractionated Radiation

(2011) Dörthe Schaue et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Blockade of Tumor Necrosis Factor   Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy

(2010) Y. Meng et al.   CANCER RESEARCH

Radiation Enhances Regulatory T Cell Representation

(2010) Evelyn L. Kachikwu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation

(2010) Satoko Matsumura et al.   RADIATION RESEARCH

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

(2009) Y. Lee et al.   BLOOD

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

(2009) J. S. Ko et al.   CLINICAL CANCER RESEARCH

Systemic effects of local radiotherapy

(2009) Silvia C Formenti et al.   LANCET ONCOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Low-Dose Radiation-Induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radioresistant

(2009) Kelvin K. C. Tsai et al.   RADIATION RESEARCH

 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

(2008) C. C. Park et al.   CANCER RESEARCH

Breast Carcinoma-Associated Fibroblasts and Their Counterparts Display Neoplastic-Specific Changes

(2008) N. M. Hawsawi et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

Irradiated fibroblast-induced bystander effects on invasive growth of squamous cell carcinoma under cancer-stromal cell interaction

(2008) Noriyuki Kamochi et al.   CANCER SCIENCE

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy

(2008) D. Schaue et al.   CLINICAL CANCER RESEARCH

The Acidic Tumor Microenvironment Promotes the Reconversion of Nitrite into Nitric Oxide: Towards a New and Safe Radiosensitizing Strategy

(2008) F. Frerart et al.   CLINICAL CANCER RESEARCH

Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells

(2008) Chandramu Chetty et al.   INTERNATIONAL JOURNAL OF CANCER

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

(2008) R. R. Weichselbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE