Cancer-associated fibroblasts in radiotherapy: challenges and new opportunities

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Podoplanin: An emerging cancer biomarker and therapeutic target

(2018) Harini Krishnan et al.   CANCER SCIENCE

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Tumor stroma–targeted antibody-drug conjugate triggers localized anticancer drug release

(2018) Christopher Szot et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?

(2018) Mareike K. Thompson et al.   BRITISH JOURNAL OF CANCER

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer associated fibroblasts: is the force the path to the dark side?

(2018) Jorge Barbazán et al.   CURRENT OPINION IN CELL BIOLOGY

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

(2017) Cecilia S. Leung et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma

(2017) Y Qiao et al.   ONCOGENE

Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors

(2017) J S K Chan et al.   ONCOGENE

CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma

(2017) Hongfang Zhang et al.   Cell Death & Disease

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in the Tumor Microenvironment After Radiotherapy

(2017) Genichiro Ishii   EBioMedicine

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

(2017) Yongbin Wang et al.   EBioMedicine

Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts

(2017) Maria Tunset Grinde et al.   Scientific Reports

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Role of interleukin-6 in cancer progression and therapeutic resistance

(2016) Neeraj Kumari et al.   TUMOR BIOLOGY

PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas

(2016) Vinay K. Kartha et al.   PLoS One

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

(2015) E. M. Dijkgraaf et al.   ANNALS OF ONCOLOGY

Irradiated fibroblasts promote epithelial–mesenchymal transition and HDGF expression of esophageal squamous cell carcinoma

(2015) Ci-Hang Bao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance

(2015) Birgitte Grum-Schwensen et al.   BMC CANCER

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

(2015) A. Lo et al.   CANCER RESEARCH

Emerging Treatment Paradigms in Radiation Oncology

(2015) Q.-T. Le et al.   CLINICAL CANCER RESEARCH

Onartuzumab in lung cancer: the fall of Icarus?

(2015) Christian Rolfo et al.   Expert Review of Anticancer Therapy

Impact of neoadjuvant therapy on cancer-associated fibroblasts in rectal cancer

(2015) Laurine Verset et al.   RADIOTHERAPY AND ONCOLOGY

TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer

(2015) Satoshi Fujii et al.   Cancer Medicine

Simultaneous Irradiation of Fibroblasts and Carcinoma Cells Repress the Secretion of Soluble Factors Able to Stimulate Carcinoma Cell Migration

(2015) Adnan Arshad et al.   PLoS One

The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma

(2014) Yuichiro Matsuoka et al.   APMIS

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crosstalk with Cancer-Associated Fibroblasts Increases the Growth and Radiation Survival of Cervical Cancer Cells

(2014) Tang-Yuan Chu et al.   RADIATION RESEARCH

Changes in the Secretory Profile of NSCLC-Associated Fibroblasts after Ablative Radiotherapy: Potential Impact on Angiogenesis and Tumor Growth

(2014) Turid Hellevik et al.   Translational Oncology

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

(2013) T Nagasaki et al.   BRITISH JOURNAL OF CANCER

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

Therapeutic Targeting of Tumor Growth and Angiogenesis with a Novel Anti-S100A4 Monoclonal Antibody

(2013) Jose Luis Hernández et al.   PLoS One

Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced

(2012) Turid Hellevik et al.   Radiation Oncology

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy

(2011) Saigusa   INTERNATIONAL JOURNAL OF ONCOLOGY

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

(2011) J. T. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines

(2010) Wiltrud Lederle et al.   INTERNATIONAL JOURNAL OF CANCER

Irradiated fibroblast-induced bystander effects on invasive growth of squamous cell carcinoma under cancer-stromal cell interaction

(2008) Noriyuki Kamochi et al.   CANCER SCIENCE

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

(2008) R. R. Weichselbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA