Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies
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Title
Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies
Authors
Keywords
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Journal
Science Translational Medicine
Volume 11, Issue 499, Pages eaau9240
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-07-04
DOI
10.1126/scitranslmed.aau9240
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Note: Only part of the references are listed.- Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
- (2018) Elisa Peranzoni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T cell–induced CSF1 promotes melanoma resistance to PD1 blockade
- (2018) Natalie J. Neubert et al. Science Translational Medicine
- Integrin CD11b activation drives anti-tumor innate immunity
- (2018) Michael C. Schmid et al. Nature Communications
- Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
- (2017) Timothy M Nywening et al. GUT
- CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus
- (2017) Mohd Hafeez Faridi et al. JOURNAL OF CLINICAL INVESTIGATION
- CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
- (2016) Colin W. Steele et al. CANCER CELL
- Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ
- (2016) Amy E. Moran et al. JOURNAL OF IMMUNOLOGY
- Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
- (2016) Hong Jiang et al. NATURE MEDICINE
- Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model
- (2016) Nadia M. Luheshi et al. Oncotarget
- Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade
- (2016) Nina Eissler et al. OncoImmunology
- Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats
- (2015) Jawahar Jagarapu et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor
- (2015) Gary E Grajales-Reyes et al. NATURE IMMUNOLOGY
- Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment
- (2015) A. Zippelius et al. Cancer Immunology Research
- Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells
- (2014) Brian Ruffell et al. CANCER CELL
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
- (2014) Y. Zhu et al. CANCER RESEARCH
- Physical and mechanical regulation of macrophage phenotype and function
- (2014) Frances Y. McWhorter et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
- (2014) Ingunn M Stromnes et al. GUT
- Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury
- (2013) Mohd Hafeez Faridi et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Agonist Leukadherin-1 Increases CD11b/CD18-Dependent Adhesion Via Membrane Tethers
- (2013) Emrah Celik et al. BIOPHYSICAL JOURNAL
- Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy
- (2013) S. Mok et al. CANCER RESEARCH
- Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
- (2013) D. E. Sanford et al. CLINICAL CANCER RESEARCH
- Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
- (2012) Lauren J. Bayne et al. CANCER CELL
- Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
- (2012) Yuliya Pylayeva-Gupta et al. CANCER CELL
- Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
- (2012) J. B. Mitchem et al. CANCER RESEARCH
- Macrophage plasticity and polarization: in vivo veritas
- (2012) Antonio Sica et al. JOURNAL OF CLINICAL INVESTIGATION
- Zbtb46expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages
- (2012) Ansuman T. Satpathy et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature
- (2012) Qiong-wen Zhang et al. PLoS One
- Combined Blockade of Integrin- 4 1 Plus Cytokines SDF-1 or IL-1 Potently Inhibits Tumor Inflammation and Growth
- (2011) M. C. Schmid et al. CANCER RESEARCH
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- Small Molecule-Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease
- (2011) D. Maiguel et al. Science Signaling
- Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
- (2011) David G. DeNardo et al. Cancer Discovery
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- (2010) Bin-Zhi Qian et al. CELL
- Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma
- (2010) Richard E. Royal et al. JOURNAL OF IMMUNOTHERAPY
- Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
- (2010) Chaofeng Han et al. NATURE IMMUNOLOGY
- Integrins limit the Toll
- (2010) Terry K Means et al. NATURE IMMUNOLOGY
- Structure of an integrin with an αI domain, complement receptor type 4
- (2009) Can Xie et al. EMBO JOURNAL
- Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures
- (2009) E. Van Goethem et al. JOURNAL OF IMMUNOLOGY
- Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice
- (2009) Michael P Kim et al. Nature Protocols
- Integrin-dependent phagocytosis - spreading from microadhesion to new concepts
- (2008) A. G. Dupuy et al. JOURNAL OF CELL SCIENCE
- Macrophages define the invasive microenvironment in breast cancer
- (2008) Jeffrey W. Pollard JOURNAL OF LEUKOCYTE BIOLOGY
- Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity
- (2008) K. Hildner et al. SCIENCE
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