The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study

(2019) Cate Speake et al.   Frontiers in Immunology

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

(2019) Alice E. Wiedeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway

(2019) Stuart P. Weisberg et al.   Cell Reports

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

(2018) Anoop Arunagiri et al.   Annals of the New York Academy of Sciences

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

Effects of proinsulin misfolding on β-cell dynamics, differentiation and function in diabetes

(2018) Yael Riahi et al.   DIABETES OBESITY & METABOLISM

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Type 1 diabetes mellitus

(2017) Anastasia Katsarou et al.   Nature Reviews Disease Primers

The viral paradigm in type 1 diabetes: Who are the main suspects?

(2016) Teresa Rodriguez-Calvo et al.   AUTOIMMUNITY REVIEWS

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?: Figure 1

(2015) Teresa Rodriguez-Calvo et al.   DIABETES

Prevention and Reversal of Type 1 Diabetes—Past Challenges and Future Opportunities

(2015) Jay S. Skyler   DIABETES CARE

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept?

(2015) Xia Li et al.   PEDIATRIC DIABETES

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

Visualizing T Cell Migration in situ

(2014) Alexandre P. Benechet et al.   Frontiers in Immunology

Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes

(2013) J. Chee et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes

(2011) Kate L. Graham et al.   AMERICAN JOURNAL OF PATHOLOGY

How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited

(2011) M. A. Atkinson et al.   DIABETES

Immunological perspective of self versus tumor antigens: insights from the RIP-gp model

(2011) Dilan Dissanayake et al.   IMMUNOLOGICAL REVIEWS

Intravital imaging of CTLs killing islet cells in diabetic mice

(2011) Ken Coppieters et al.   JOURNAL OF CLINICAL INVESTIGATION

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY