Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1cin New-Onset Type 1 Diabetes

(2018) Michael J. Haller et al.   DIABETES CARE

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

(2018) Lorraine Yeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

(2018) Cristina Rius et al.   JOURNAL OF IMMUNOLOGY

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

(2016) Anne M. Pesenacker et al.   DIABETES

Clinical trial data access: Opening doors with TrialShare

(2016) Adam L. Asare et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

(2016) Christian Hundhausen et al.   Science Translational Medicine

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

(2016) John A. Todd et al.   PLOS MEDICINE

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

(2014) W. S. Thompson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

(2014) T. Orban et al.   DIABETES

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes

(2014) Michael J. Haller et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of CD4+ T Cell Responses to Glutamic Acid Decarboxylase 65 Using DQ8 Tetramers Reveals a Pathogenic Role of GAD65 121–140 and GAD65 250–266 in T1D Development

(2014) I-Ting Chow et al.   PLoS One

Cross-Validation of IFN-γ Elispot Assay for Measuring Alloreactive Memory/Effector T Cell Responses in Renal Transplant Recipients

(2013) O. Bestard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders

(2013) K. C. Herold et al.   DIABETES

Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial

(2013) J. M. Lachin et al.   DIABETES

Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression

(2013) M. Galgani et al.   DIABETES

B-Lymphocyte Depletion With Rituximab and  -Cell Function: Two-Year Results

(2013) M. D. Pescovitz et al.   DIABETES CARE

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

(2013) Tihamer Orban et al.   DIABETES CARE

Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells

(2013) Francesca Giannoni et al.   MOLECULAR THERAPY

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes

(2012) Katharine M. Irvine et al.   DIABETES

Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies

(2012) L. Yu et al.   DIABETES CARE

A Partial Least Squares based algorithm for parsimonious variable selection

(2011) Tahir Mehmood et al.   Algorithms for Molecular Biology

Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative

(2011) R. Mallone et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Harmonization of Glutamic Acid Decarboxylase and Islet Antigen-2 Autoantibody Assays for National Institute of Diabetes and Digestive and Kidney Diseases Consortia

(2010) Ezio Bonifacio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

(2009) K. C. Herold et al.   DIABETES

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers

(2009) Sine Reker Hadrup et al.   NATURE METHODS

A real-time polymerase chain reaction assay for the rapid identification of the autoimmune disease-associated allele HLA-DQB1*0602

(2009) V. H. Gersuk et al.   TISSUE ANTIGENS

Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of  -Cell Function in Therapeutic Trials in Type 1 Diabetes

(2008) C. J. Greenbaum et al.   DIABETES CARE

Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells

(2008) Shuya Y. Kyu et al.   JOURNAL OF IMMUNOLOGICAL METHODS