Effects of proinsulin misfolding on β-cell dynamics, differentiation and function in diabetes

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

How Are Proteins Reduced in the Endoplasmic Reticulum?

(2018) Lars Ellgaard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation

(2016) Alexandra E. Butler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

(2016) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

(2015) Jaeseok Han et al.   DIABETES

A Missense Mutation inPPP1R15BCauses a Syndrome Including Diabetes, Short Stature, and Microcephaly

(2015) Baroj Abdulkarim et al.   DIABETES

Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene,PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability

(2015) Kristin D. Kernohan et al.   HUMAN MOLECULAR GENETICS

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

INS-gene mutations: From genetics and beta cell biology to clinical disease

(2015) Ming Liu et al.   MOLECULAR ASPECTS OF MEDICINE

Absence of BiP Co-chaperone DNAJC3 Causes Diabetes Mellitus and Multisystemic Neurodegeneration

(2014) Matthis Synofzik et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Microscopic and ultrastructural features in Wolcott-Rallison syndrome, a permanent neonatal diabetes mellitus: about two autopsy cases

(2014) Sophie Collardeau-Frachon et al.   PEDIATRIC DIABETES

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress

(2013) Jordan Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs

(2012) S. Renner et al.   DIABETES

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

(2011) Yoshifumi Saisho et al.   DIABETES

In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes

(2011) I. Hodish et al.   DIABETES

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Gene Expression and Genetic Variation in Response to Endoplasmic Reticulum Stress in Human Cells

(2010) Beth A. Dombroski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

What ails the β-cell?

(2010) D. Accili et al.   DIABETES OBESITY & METABOLISM

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

The emerging genetics of type 2 diabetes

(2010) Amélie Bonnefond et al.   TRENDS IN MOLECULAR MEDICINE

Comparative Analysis of the Islet Proteome between NOD/Lt and ALR/Lt Mice

(2009) Ping Yang et al.   Annals of the New York Academy of Sciences

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

(2009) Israel Hodish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinsulin and the Genetics of Diabetes Mellitus

(2009) Michael A. Weiss   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

(2009) Tomokazu Matsuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Insulin Gene Mutations as Cause of Diabetes in Children Negative for Five Type 1 Diabetes Autoantibodies

(2008) R. Bonfanti et al.   DIABETES CARE

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

(2008) Kathryn L. Lipson et al.   PLoS One