Intrinsic Restriction of TNF-Mediated Inflammatory Osteoclastogenesis and Bone Resorption

Regulatory network mediated by RBP‐J/NFATc1‐miR182 controls inflammatory bone resorption

(2019) Kazuki Inoue et al.   FASEB JOURNAL

Bone protection by inhibition of microRNA-182

(2018) Kazuki Inoue et al.   Nature Communications

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption

(2017) Nikolaus Binder et al.   JOURNAL OF IMMUNOLOGY

TNF and Bone Remodeling

(2017) Baohong Zhao   Current Osteoporosis Reports

RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis

(2016) Christine H. Miller et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8

(2016) Celestia Fang et al.   JOURNAL OF IMMUNOLOGY

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

(2016) Yingli Shang et al.   Protein & Cell

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

(2016) Julia Foldi et al.   Protein & Cell

DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

(2015) Keizo Nishikawa et al.   NATURE MEDICINE

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

(2014) Susan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

(2014) Hengwei Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

(2014) Gaurav Swarnkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone ResorptionIn VitroandIn Vivo

(2013) Hideki Kitaura et al.   Clinical & Developmental Immunology

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation

(2012) Jing Ma et al.   MOLECULAR BIOLOGY REPORTS

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Identification of Novel Targets of CSL-Dependent Notch Signaling in Hematopoiesis

(2011) Habib Hamidi et al.   PLoS One

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages

(2011) A. Yarilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IKKβ activation is sufficient for RANK-independent osteoclast differentiation and osteolysis

(2010) Jesse E Otero et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

(2010) Yoshiteru Miyauchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Processing of the NF-κB2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation

(2009) Toshimasa Maruyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclasts and Arthritis

(2009) Georg Schett et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Pivotal Role of the Alternative NF-κB Pathway in Maintenance of Basal Bone Homeostasis and Osteoclastogenesis

(2009) Niroshani S Soysa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

NF- B Serves as a Cellular Sensor of Kaposi's Sarcoma-Associated Herpesvirus Latency and Negatively Regulates K-Rta by Antagonizing the RBP-J  Coactivator

(2009) Y. Izumiya et al.   JOURNAL OF VIROLOGY

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

(2009) Baohong Zhao et al.   NATURE MEDICINE

Id1 Represses Osteoclast-Dependent Transcription and Affects Bone Formation and Hematopoiesis

(2009) April S. Chan et al.   PLoS One

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

(2008) Qinzhong Chen et al.   IMMUNITY

Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

(2008) Xiaoyu Hu et al.   IMMUNITY

Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases

(2008) Qinzhong Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Stabilized  -Catenin Functions through TCF/LEF Proteins and the Notch/RBP-J  Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells

(2008) T. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

RelB is the NF- B subunit downstream of NIK responsible for osteoclast differentiation

(2008) S. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood

(2008) Qian Zhang et al.   ARTHRITIS RESEARCH & THERAPY