NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

Parenchymal Cell TNF Receptors Contribute to Inflammatory Cell Recruitment and Respiratory Failure in Pneumocystis carinii-Induced Pneumonia

(2014) G. S. Pryhuber et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

(2013) Jong-Sung Park et al.   ANNALS OF THE RHEUMATIC DISEASES

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

(2013) Giovanni Roti et al.   CANCER CELL

NF-κB RelB Negatively Regulates Osteoblast Differentiation and Bone Formation

(2013) Zhenqiang Yao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus

(2013) A. Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Ubiquitin E3 Ligase Itch Negatively Regulates Osteoblast Differentiation from Mesenchymal Progenitor Cells

(2013) Hengwei Zhang et al.   STEM CELLS

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

(2012) Wei Gao et al.   ARTHRITIS AND RHEUMATISM

In situ imaging of the autonomous intracellular Ca2+ oscillations of osteoblasts and osteocytes in bone

(2012) Yoshihito Ishihara et al.   BONE

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Role of notch signaling in osteoimmunology--from the standpoint of osteoclast differentiation

(2012) L. Duan et al.   EUROPEAN JOURNAL OF ORTHODONTICS

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB Signaling Regulates Hematopoietic Stem Cell Self-Renewal and Microenvironment Interactions

(2012) Chen Zhao et al.   STEM CELLS

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

(2012) Chiyoko Sekine et al.   ARTHRITIS RESEARCH & THERAPY

Notch and NF-κB Signaling Pathways in the Biology of Classical Hodgkin Lymphoma

(2011) R. Schwarzer et al.   CURRENT MOLECULAR MEDICINE

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1

(2011) Lan Zhao et al.   STEM CELLS

Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor

(2011) James J Kobie et al.   ARTHRITIS RESEARCH & THERAPY

Functions of nuclear factor κB in bone

(2010) Brendan F. Boyce et al.   Annals of the New York Academy of Sciences

Alteration of Notch signaling in skeletal development and disease

(2010) Jianning Tao et al.   Annals of the New York Academy of Sciences

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone

(2010) Heng Zhu et al.   Nature Protocols

TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy

(2010) Swarnali Acharyya et al.   PLoS One

Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease

(2010) Henrik Zetterberg et al.   Alzheimers Research & Therapy

γ-secretase inhibitors for the treatment of Alzheimer's disease

(2009) Wen-Lian Wu et al.   DRUG DEVELOPMENT RESEARCH

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice

(2009) Heng-Wei Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

(2009) Baohong Zhao et al.   NATURE MEDICINE

Inhibition of osteoblastic bone formation by nuclear factor-κB

(2009) Jia Chang et al.   NATURE MEDICINE

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

(2009) R. Majeti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Tumor necrosis factor-α and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

(2008) Luis Fernandez et al.   EXPERIMENTAL HEMATOLOGY

Ubiquitin Ligase Smurf1 Mediates Tumor Necrosis Factor-induced Systemic Bone Loss by Promoting Proteasomal Degradation of Bone Morphogenetic Signaling Proteins

(2008) Ruolin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

(2008) Sergio Vaira et al.   JOURNAL OF CLINICAL INVESTIGATION

Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor

(2008) N Brownlow et al.   LEUKEMIA

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

Targeting Notch signaling in autoimmune and lymphoproliferative disease

(2007) D. T. Teachey et al.   BLOOD