Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

(2016) Celi Sun et al.   NATURE GENETICS

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

SnapShot: Osteoimmunology

(2015) Hiroshi Takayanagi   Cell Metabolism

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus

(2015) Michela Manni et al.   PLoS One

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

(2014) Susan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP3 receptor 1 promotes Ca2+ signaling in T cells

(2014) C. Fos et al.   Science Signaling

Osteoimmunology and Its Implications for Transplantation

(2013) R. Pacifici   AMERICAN JOURNAL OF TRANSPLANTATION

Advances in the Regulation of Osteoclasts and Osteoclast Functions

(2013) B.F. Boyce   JOURNAL OF DENTAL RESEARCH

SLAT negatively regulates RANKL-induced osteoclast differentiation

(2013) Bang Ung Youn et al.   MOLECULES AND CELLS

Osteoimmunology and Bone Homeostasis: Relevance to Spondyloarthritis

(2013) Steven R. Goldring   Current Rheumatology Reports

Bone remodelling in inflammatory arthritis

(2012) Steven R Goldring et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of bone mass and osteoclast function depend on the F-actin modulator SWAP-70

(2012) Annette I Garbe et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity

(2012) Partha S. Biswas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts

(2012) J. B. Regard et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional control of T-cell development

(2011) T. Naito et al.   INTERNATIONAL IMMUNOLOGY

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70

(2010) G. Pearce et al.   BLOOD

Cellular and Molecular Mechanisms of Bone Remodeling

(2010) Liza J. Raggatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

(2010) Yoshiteru Miyauchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

(2010) K. Nishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does Def6 Deficiency Cause Autoimmunity?

(2009) Amnon Altman et al.   IMMUNITY

IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

(2009) Partha S. Biswas et al.   IMMUNOLOGICAL REVIEWS

Osteoclasts and Arthritis

(2009) Georg Schett et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoimmunology in rheumatic diseases

(2009) Georg Schett   ARTHRITIS RESEARCH & THERAPY

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Osteoclast–osteoblast communication

(2008) Koichi Matsuo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tyrosine-Phosphorylation-Dependent Translocation of the SLAT Protein to the Immunological Synapse Is Required for NFAT Transcription Factor Activation

(2008) Stéphane Bécart et al.   IMMUNITY

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

(2008) Qinzhong Chen et al.   IMMUNITY

Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases

(2008) Qinzhong Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY