TNF and Bone Remodeling

Notch Signaling and the Skeleton

(2016) Stefano Zanotti et al.   ENDOCRINE REVIEWS

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

(2016) Yingli Shang et al.   Protein & Cell

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

(2016) Julia Foldi et al.   Protein & Cell

Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations

(2016) Ernesto Canalis et al.   Current Osteoporosis Reports

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption

(2015) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes

(2015) K. Algate et al.   JOURNAL OF PERIODONTAL RESEARCH

Notch Activation as a Driver of Osteogenic Sarcoma

(2014) Jianning Tao et al.   CANCER CELL

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

(2014) Susan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

(2014) Hengwei Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells

(2014) C. M. Krawczyk et al.   JOURNAL OF IMMUNOLOGY

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

(2014) Gaurav Swarnkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoclasts: more than ‘bone eaters’

(2014) Julia F. Charles et al.   TRENDS IN MOLECULAR MEDICINE

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines

(2013) Etsuko Matsuzaki et al.   BONE

Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone ResorptionIn VitroandIn Vivo

(2013) Hideki Kitaura et al.   Clinical & Developmental Immunology

TGF-β Induces Wnt10b in Osteoclasts From Female Mice to Enhance Coupling to Osteoblasts

(2013) Kuniaki Ota et al.   ENDOCRINOLOGY

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling

(2013) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

(2013) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Notch Signaling and Bone Remodeling

(2013) Jenna Regan et al.   Current Osteoporosis Reports

Bone remodelling in inflammatory arthritis

(2012) Steven R Goldring et al.   ANNALS OF THE RHEUMATIC DISEASES

Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-α in human mesenchymal stem cells

(2012) A. Briolay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osteoblast Lineage-Specific Effects of Notch Activation in the Skeleton

(2012) Ernesto Canalis et al.   ENDOCRINOLOGY

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation

(2012) Jing Ma et al.   MOLECULAR BIOLOGY REPORTS

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation

(2012) ZuFu Lu et al.   STEM CELLS AND DEVELOPMENT

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

(2012) Chiyoko Sekine et al.   ARTHRITIS RESEARCH & THERAPY

Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts

(2012) J. B. Regard et al.   Cold Spring Harbor Perspectives in Biology

Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells

(2011) H. Huang et al.   CELL PROLIFERATION

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

Identification of Novel Targets of CSL-Dependent Notch Signaling in Hematopoiesis

(2011) Habib Hamidi et al.   PLoS One

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1

(2011) Lan Zhao et al.   STEM CELLS

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

(2010) Jianning Tao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway

(2009) Katrin Hess et al.   BONE

Notch signaling and the bone marrow hematopoietic stem cell niche

(2009) Jonathan M. Weber et al.   BONE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

(2009) Joanne B. Tan et al.   IMMUNITY

Osteoclasts and Arthritis

(2009) Georg Schett et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF- B Serves as a Cellular Sensor of Kaposi's Sarcoma-Associated Herpesvirus Latency and Negatively Regulates K-Rta by Antagonizing the RBP-J  Coactivator

(2009) Y. Izumiya et al.   JOURNAL OF VIROLOGY

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

(2009) Baohong Zhao et al.   NATURE MEDICINE

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Promising bone-related therapeutic targets for rheumatoid arthritis

(2009) Yongwon Choi et al.   Nature Reviews Rheumatology

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

(2008) Xiaoyu Hu et al.   IMMUNITY

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

Stabilized  -Catenin Functions through TCF/LEF Proteins and the Notch/RBP-J  Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells

(2008) T. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood

(2008) Qian Zhang et al.   ARTHRITIS RESEARCH & THERAPY