RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGF  signaling to specify V2b interneurons in the spinal cord

(2013) K. Misra et al.   DEVELOPMENT

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

(2013) Chiara Sassoli et al.   PLoS One

Novel Rheumatoid Arthritis Susceptibility Locus at 22q12 Identified in an Extended UK Genome-Wide Association Study

(2013) Gisela Orozco et al.   Arthritis & Rheumatology

Transforming Growth Factor–β Evokes Ca2+Waves and Enhances Gene Expression in Human Pulmonary Fibroblasts

(2012) Subhendu Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

New regulation mechanisms of osteoclast differentiation

(2012) Tomoki Nakashima et al.   Annals of the New York Academy of Sciences

Role of ITAM signaling module in signal integration

(2012) Jelena S Bezbradica et al.   CURRENT OPINION IN IMMUNOLOGY

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Genome-Wide Analysis of N1ICD/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1

(2012) Yaochen Li et al.   STEM CELLS

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6

(2011) Tetsuro Yasui et al.   JOURNAL OF BONE AND MINERAL RESEARCH

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Novel Targets of CSL-Dependent Notch Signaling in Hematopoiesis

(2011) Habib Hamidi et al.   PLoS One

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages

(2011) A. Yarilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

Integrins, growth factors, and the osteoclast cytoskeleton

(2010) Wei Zou et al.   Annals of the New York Academy of Sciences

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

(2010) Yoshiteru Miyauchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

(2010) K. Nishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

NOTCHing the bone: Insights into multi-functionality

(2009) Feyza Engin et al.   BONE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

(2009) Takako Negishi-Koga et al.   IMMUNOLOGICAL REVIEWS

Osteoclasts and Arthritis

(2009) Georg Schett et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IL-10 Suppresses Calcium-Mediated Costimulation of Receptor Activator NF- B Signaling during Human Osteoclast Differentiation by Inhibiting TREM-2 Expression

(2009) K.-H. Park-Min et al.   JOURNAL OF IMMUNOLOGY

NF- B Serves as a Cellular Sensor of Kaposi's Sarcoma-Associated Herpesvirus Latency and Negatively Regulates K-Rta by Antagonizing the RBP-J  Coactivator

(2009) Y. Izumiya et al.   JOURNAL OF VIROLOGY

Cross-regulation of signaling by ITAM-associated receptors

(2009) Lionel B Ivashkiv   NATURE IMMUNOLOGY

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

(2009) Baohong Zhao et al.   NATURE MEDICINE

TGF-β mediates PTEN suppression and cell motility through calcium-dependent PKC-α activation in pancreatic cancer cells

(2008) Jimmy Y. C. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

(2008) Masahiro Shinohara et al.   CELL

Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

(2008) Xiaoyu Hu et al.   IMMUNITY

Stabilized  -Catenin Functions through TCF/LEF Proteins and the Notch/RBP-J  Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells

(2008) T. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk

(2008) Wei Zou et al.   MOLECULAR CELL

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE