Role of Notch signaling in regulating innate immunity and inflammation in health and disease

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

(2015) Jun Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch Signaling in Inflammation-Induced Preterm Labor

(2015) Mukesh K. Jaiswal et al.   Scientific Reports

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

(2014) Susan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

(2014) Gaurav Swarnkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

(2013) Jong-Sung Park et al.   ANNALS OF THE RHEUMATIC DISEASES

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

(2012) Aditya Murthy et al.   IMMUNITY

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

(2012) Chiyoko Sekine et al.   ARTHRITIS RESEARCH & THERAPY

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine

(2011) Kanako L. Lewis et al.   IMMUNITY

Notch Signal Suppresses Toll-like Receptor-triggered Inflammatory Responses in Macrophages by Inhibiting Extracellular Signal-regulated Kinase 1/2-mediated Nuclear Factor κB Activation

(2011) Qinghua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Identification of Novel Targets of CSL-Dependent Notch Signaling in Hematopoiesis

(2011) Habib Hamidi et al.   PLoS One

Interleukin-19: A Constituent of the Regulome That Controls Antigen Presenting Cells in the Lungs and Airway Responses to Microbial Products

(2011) Carol Hoffman et al.   PLoS One

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

(2011) B. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

The Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A Virus (H1N1) Infection

(2011) Toshihiro Ito et al.   PLoS Pathogens

The network of cytokines, receptors and transcription factors governing the development of dendritic cell subsets

(2011) Priyanka Sathe et al.   Protein & Cell

Functions of Notch Signaling in the Immune System: Consensus and Controversies

(2010) Julie S. Yuan et al.   Annual Review of Immunology

The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia

(2010) Lluis Espinosa et al.   CANCER CELL

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

The Notch pathway in the developing hematopoietic system

(2010) Anna Bigas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

(2010) David R. Gibb et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J-Dependent Induction of Jagged1

(2010) J. Foldi et al.   JOURNAL OF IMMUNOLOGY

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Nitric Oxide Is Involved in Mycobacterium bovis Bacillus Calmette-Guerin-Activated Jagged1 and Notch1 Signaling

(2010) N. Kapoor et al.   JOURNAL OF IMMUNOLOGY

Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages

(2010) H. Hamilton Outtz et al.   JOURNAL OF IMMUNOLOGY

Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

(2010) Mariana Murea et al.   KIDNEY INTERNATIONAL

The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice

(2010) Fan Feng et al.   Molecular Cancer

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis

(2010) Z Jiao et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Notch regulation of early thymocyte development

(2010) Yumi Yashiro-Ohtani et al.   SEMINARS IN IMMUNOLOGY

Hes1, a new target for interleukin 1  in chondrocytes

(2009) S. Ottaviani et al.   ANNALS OF THE RHEUMATIC DISEASES

γ-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice

(2009) Toru Aoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch1 upregulates LPS-induced macrophage activation by increasing NF-κB activity

(2009) Eva Monsalve et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Notch and Wingless Signaling Cooperate in Regulation of Dendritic Cell Differentiation

(2009) Jie Zhou et al.   IMMUNITY

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands

(2009) C. Sekine et al.   INTERNATIONAL IMMUNOLOGY

Lipopolysaccharide-induced Maturation of Bone Marrow-derived Dendritic Cells Is Regulated by Notch Signaling through the Up-regulation of CXCR4

(2009) Yao-Chun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M. bovis BCG induced expression of COX-2 involves nitric oxide-dependent and -independent signaling pathways

(2009) Kushagra Bansal et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

(2008) Xiaoyu Hu et al.   IMMUNITY

Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen fromSchistosoma mansoniinvolves ERK signalling

(2008) Felicia Goh et al.   IMMUNOLOGY

NOTCH1 Up-regulation and Signaling Involved inMycobacterium bovisBCG-induced SOCS3 Expression in Macrophages

(2008) Yeddula Narayana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition

(2008) Chin-Tong Ong et al.   PLoS One

Presenilin: RIP and beyond

(2008) Matthew R. Hass et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

(2008) Shadmehr Demehri et al.   PLOS BIOLOGY

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY