Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

(2019) Kritika Mohan et al.   SCIENCE

The regulation of JAKs in cytokine signaling and its breakdown in disease

(2018) Henrik M. Hammarén et al.   CYTOKINE

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase

(2018) Stevan R. Hubbard   Frontiers in Endocrinology

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

(2018) Ryan D Ferrao et al.   eLife

Martini straight: Boosting performance using a shorter cutoff and GPUs

(2016) Djurre H. de Jong et al.   COMPUTER PHYSICS COMMUNICATIONS

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

(2016) Ryan Ferrao et al.   STRUCTURE

Crystal Structure of the FERM-SH2 Module of Human Jak2

(2016) Randall McNally et al.   PLoS One

JAK2 activation by growth hormone and other cytokines

(2015) Michael J. Waters et al.   BIOCHEMICAL JOURNAL

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

(2015) O. Silvennoinen et al.   BLOOD

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Single Cell GFP-Trap Reveals Stoichiometry and Dynamics of Cytosolic Protein Complexes

(2015) Tim Wedeking et al.   NANO LETTERS

Spatiotemporally Controlled Reorganization of Signaling Complexes in the Plasma Membrane of Living Cells

(2015) Tim Wedeking et al.   Small

Rapid Transfer of Transmembrane Proteins for Single Molecule Dimerization Assays in Polymer-Supported Membranes

(2014) Friedrich Roder et al.   ACS Chemical Biology

Dynamic Submicroscopic Signaling Zones Revealed by Pair Correlation Tracking and Localization Microscopy

(2014) Changjiang You et al.   ANALYTICAL CHEMISTRY

Structural Insight into the Transmembrane Domain and the Juxtamembrane Region of the Erythropoietin Receptor in Micelles

(2014) Qingxin Li et al.   BIOPHYSICAL JOURNAL

Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane

(2014) Sara Löchte et al.   JOURNAL OF CELL BIOLOGY

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

(2014) Yibing Shan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

(2014) Heidi J A Wallweber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

(2014) P. J. Lupardus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis

(2013) G. B. Bulut et al.   BLOOD

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

A flexible algorithm for calculating pair interactions on SIMD architectures

(2013) Szilárd Páll et al.   COMPUTER PHYSICS COMMUNICATIONS

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

CHARMM36 United Atom Chain Model for Lipids and Surfactants

(2013) Sarah Lee et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases

(2013) Angela V Toms et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation

(2013) J.-P. Defour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding cytokine and growth factor receptor activation mechanisms

(2012) Mariya Atanasova et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

(2012) Rajintha M Bandaranayake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

Quantification of Biological Interactions with Particle Image Cross-Correlation Spectroscopy (PICCS)

(2011) Stefan Semrau et al.   BIOPHYSICAL JOURNAL

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

(2011) Erin E. Matthews et al.   FASEB JOURNAL

Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

(2011) Patrick J. Lupardus et al.   STRUCTURE

Functional Immobilization and Patterning of Proteins by an Enzymatic Transfer Reaction

(2010) Sharon Waichman et al.   ANALYTICAL CHEMISTRY

The Constitutive Activation of Jak2-V617F Is Mediated by a π Stacking Mechanism Involving Phenylalanines 595 and 617

(2010) Kavitha Gnanasambandan et al.   BIOCHEMISTRY

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

JAK2 V617F Constitutive Activation Requires JH2 Residue F595: A Pseudokinase Domain Target for Specific Inhibitors

(2010) Alexandra Dusa et al.   PLoS One

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

(2009) C. Pecquet et al.   BLOOD

A JAK2 Interdomain Linker Relays Epo Receptor Engagement Signals to Kinase Activation

(2009) Lequn Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coiled-Coil Tag−Probe System for Quick Labeling of Membrane Receptors in Living Cells

(2008) Yoshiaki Yano et al.   ACS Chemical Biology

A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes

(2008) Jan Vogelsang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation

(2008) I. S. Hitchcock et al.   BLOOD

Interleukin-5 Receptor Subunit Oligomerization and Rearrangement Revealed by Fluorescence Resonance Energy Transfer Imaging

(2008) Meirav Zaks-Zilberman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Control of Ion Selectivity in LeuT: Two Na+ Binding Sites with Two Different Mechanisms

(2008) Sergei Y. Noskov et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS