Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies

Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of Danio rerio

(2020) Pragyan Paramita et al.   DRUG AND CHEMICAL TOXICOLOGY

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK

(2020) Nadya M. Morrow et al.   JOURNAL OF LIPID RESEARCH

Flavonoids as Anticancer Agents

(2020) Dalia M. Kopustinskiene et al.   Nutrients

The Citrus Flavanone Hesperetin Induces Apoptosis in CTCL Cells via STAT3/Notch1/NFκB-Mediated Signaling Axis

(2020) Amuthavalli Kottaiswamy et al.   Anti-Cancer Agents in Medicinal Chemistry

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress and diabetes: antioxidative strategies

(2020) Pengju Zhang et al.   Frontiers of Medicine

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

(2019) Ayman M. Mahmoud et al.   Oxidative Medicine and Cellular Longevity

Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death

(2019) Yu-Ting Tseng et al.   NUTRITIONAL NEUROSCIENCE

Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways

(2019) Shijie Liao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells

(2019) Md Yousof Ali et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Benefits of Hesperidin for Cutaneous Functions

(2019) Mao-Qiang Man et al.   Evidence-based Complementary and Alternative Medicine

Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells

(2019) Yoshitaka Hosokawa et al.   INFLAMMATION

Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways

(2019) Sun Hyo Jo et al.   ARCHIVES OF PHARMACAL RESEARCH

Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice

(2019) Rika Tsuhako et al.   Journal of Natural Medicines

Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers

(2019) Xuejun Zhang et al.   Nutrition & Metabolism

Neohesperidin suppresses IgE‐mediated anaphylactic reactions and mast cell activation via Lyn‐PLC‐Ca 2+ pathway

(2019) Tingting Zhao et al.   PHYTOTHERAPY RESEARCH

Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention

(2019) Goh et al.   Cancers

Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis

(2019) Xinliang Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice

(2019) Kazunari Nohara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis

(2019) Yabing Wang et al.   International Journal of Nanomedicine

Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice

(2019) Jiasen Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death

(2018) Kirtikar Shukla et al.   BIOCHEMICAL PHARMACOLOGY

Tangeretin inhibits high glucose-induced extracellular matrix accumulation in human glomerular mesangial cells

(2018) Fang Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats

(2018) Revathy Jayaraman et al.   BIOMEDICINE & PHARMACOTHERAPY

Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms

(2018) John R. Petrie et al.   CANADIAN JOURNAL OF CARDIOLOGY

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways

(2018) Fan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Escalation of liver malfunctioning: A step toward Herbal Awareness

(2018) Bushra Sultana et al.   JOURNAL OF ETHNOPHARMACOLOGY

Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops

(2018) et al.   MOLECULES

The effects of hesperidin and quercetin on serum tumor necrosis factor-alpha and interleukin-6 levels in streptozotocin-induced diabetes model

(2018) Hatice Iskender et al.   Pharmacognosy Magazine

The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors

(2018) Yoko Ohyama et al.   PLoS One

Naringin ameliorates endothelial dysfunction in fructose-fed rats

(2018) Wachirawadee Malakul et al.   Experimental and Therapeutic Medicine

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

(2018) Chuan-Hao Jiang et al.   Frontiers in Pharmacology

Citrus peel polymethoxyflavones, sudachitin and nobiletin, induce distinct cellular responses in human keratinocyte HaCaT cells

(2018) Shogo Abe et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Combating oxidative stress disorders with citrus flavonoid: Naringenin

(2018) Nurul Hannim Zaidun et al.   LIFE SCIENCES

Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis

(2018) Alireza Samie et al.   LIFE SCIENCES

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro

(2018) Won-Jae Kim et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin

(2018) Qing Yao et al.   MOLECULES

The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function

(2018) Amy Rees et al.   Nutrients

Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis

(2017) AS Shalkami et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study

(2017) Sara Zareei et al.   LIFE SCIENCES

Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice

(2017) Zhen Tan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Anti-Inflammatory Properties of Citrus wilsonii Tanaka Extract in LPS-Induced RAW 264.7 and Primary Mouse Bone Marrow-Derived Dendritic Cells

(2017) Liping Cheng et al.   MOLECULES

Diosmin, a Citrus Nutrient, Activates Imidazoline Receptors to Alleviate Blood Glucose and Lipids in Type 1-Like Diabetic Rats

(2017) Chia-Chen Hsu et al.   Nutrients

Protective Effects of Hesperidin (Citrus Flavonone) on High Glucose Induced Oxidative Stress and Apoptosis in a Cellular Model for Diabetic Retinopathy

(2017) Wayne Liu et al.   Nutrients

Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line

(2017) R. Dhanya et al.   Frontiers in Pharmacology

Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model

(2017) A. I. Carballo-Villalobos et al.   INFLAMMOPHARMACOLOGY

Characterization and Metabolic Diversity of Flavonoids in Citrus Species

(2017) Shouchuang Wang et al.   Scientific Reports

Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects

(2016) Raju Gautam et al.   BMC Complementary and Alternative Medicine

The Multifunctional Effects of Nobiletin and Its MetabolitesIn VivoandIn Vitro

(2016) Hao Huang et al.   Evidence-based Complementary and Alternative Medicine

Naringin Protects Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma

(2016) Xiong Guihua et al.   INFLAMMATION

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy

(2016) Ning Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus

(2016) Mohit Kwatra et al.   NEUROCHEMICAL RESEARCH

Therapeutic potential of naringin: an overview

(2016) Rui Chen et al.   PHARMACEUTICAL BIOLOGY

Hybridization in Plants: Old Ideas, New Techniques

(2016) Benjamin E. Goulet et al.   PLANT PHYSIOLOGY

Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways

(2015) Yassine Chtourou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Health-promoting effects of the citrus flavanone hesperidin

(2015) Chaoyun Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Isoxanthohumol — Biologically active hop flavonoid

(2015) Anna Katarzyna Żołnierczyk et al.   FITOTERAPIA

In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action

(2015) Ayman M. Mahmoud et al.   International Journal of Diabetes in Developing Countries

Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model

(2015) Yu-Sheng Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults

(2015) Oscar D Rangel-Huerta et al.   JOURNAL OF NUTRITION

Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma

(2015) Hao-yan Jiao et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Tangeretin, a polymethoxylated flavone, modulates lipid homeostasis and decreases oxidative stress by inhibiting NF-κB activation and proinflammatory cytokines in cardiac tissue of streptozotocin-induced diabetic rats

(2015) Ramalingam Sundaram et al.   Journal of Functional Foods

Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice

(2015) Sheng Jia et al.   Food & Function

Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

(2015) Suvi E. Heinonen et al.   Journal of Diabetes Research

Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity

(2014) Hiroki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-depressant effect of hesperidin in diabetic rats

(2014) Salma A. El-Marasy et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines

(2014) Sheikh Fayaz Ahmad et al.   INFLAMMATION

The pathobiology of diabetic vascular complications—cardiovascular and kidney disease

(2014) Stephen P. Gray et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of naringenin in protection against diabetic hyperalgesia and tactile allodynia in male Wistar rats

(2014) Parisa Hasanein et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Development of new reference material neohesperidin for quality control of dietary supplements

(2014) Ningbo Gong et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle

(2014) Rie Tsutsumi et al.   Nutrition & Metabolism

Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions

(2014) Asjad Visnagri et al.   PHARMACEUTICAL BIOLOGY

Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction

(2014) Anand Kamal Sachdeva et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats

(2014) Ramalingam Sundaram et al.   PHYTOMEDICINE

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

(2014) M. Ashraful Alam et al.   Advances in Nutrition

Antihyperlipidemic effect of diosmin: A citrus flavonoid on lipid metabolism in experimental diabetic rats

(2013) Subramani Srinivasan et al.   Journal of Functional Foods

Diabetes and risk of physical disability in adults: a systematic review and meta-analysis

(2013) Evelyn Wong et al.   Lancet Diabetes & Endocrinology

Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells

(2012) Gon-Sup Kim et al.   BMC Complementary and Alternative Medicine

Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy

(2012) Amit D. Kandhare et al.   FITOTERAPIA

Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells

(2012) Jiukai Zhang et al.   FOOD CHEMISTRY

Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats

(2012) Mehrdad Roghani et al.   INDIAN JOURNAL OF PHARMACOLOGY

Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats

(2012) Ayman M. Mahmoud et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability

(2012) Andreia F. M. Furtado et al.   JOURNAL OF MOLECULAR RECOGNITION

Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice

(2012) Young-Sil Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polymethoxyflavonoids Tangeretin and Nobiletin Increase Glucose Uptake in Murine Adipocytes

(2012) Kenji Onda et al.   PHYTOTHERAPY RESEARCH

Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction

(2011) Kota Kanda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Didymin Induces Apoptosis by Inhibiting N-Myc and Upregulating RKIP in Neuroblastoma

(2011) J. Singhal et al.   Cancer Prevention Research

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

(2011) E. E. Mulvihill et al.   DIABETES

Analysis of genetic diversity in Citrus

(2011) François Luro et al.   Plant Genetic Resources-Characterization and Utilization

Two new c-glucosyl benzoic acids and flavonoids from Mallotus nanus and their antioxidant activity

(2010) Phan Van Kiem et al.   ARCHIVES OF PHARMACAL RESEARCH

Polymethoxylated Flavones, Flavanone Glycosides, Carotenoids, and Antioxidants in Different Cultivation Types of Tangerines (Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand

(2010) Wolfgang Stuetz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Angiogenesis and Inflammation Signaling Are Targets of Beer Polyphenols on Vascular Cells

(2010) Rita Negrão et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary Hesperidin Exerts Hypoglycemic and Hypolipidemic Effects in Streptozotocin-Induced Marginal Type 1 Diabetic Rats

(2010) Satoko Akiyama et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: Potential prophylactic ingredients for functional foods application

(2010) Deena Ramful et al.   TOXICOLOGY

Influence of rutin treatment on biochemical alterations in experimental diabetes

(2009) Ana Angélica Henrique Fernandes et al.   BIOMEDICINE & PHARMACOTHERAPY

Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated fromCitrus grandis(L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells

(2009) Yerra Koteswara Rao et al.   Evidence-based Complementary and Alternative Medicine

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant

(2009) Garima Vij et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo

(2009) Jen-Yu Hung et al.   LUNG CANCER

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE

Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells

(2008) Sam-Long Hwang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of l-rhamnosyl-d-glucosyl derivatives on properties and biological interaction of flavonoids

(2008) Ersilia Bellocco et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dietary Flavonoid Sources in Australian Adults

(2008) Shawn M. Somerset et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL