Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
出版年份 2020 全文链接
标题
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
作者
关键词
-
出版物
Nutrients
Volume 12, Issue 10, Pages 2907
出版商
MDPI AG
发表日期
2020-09-23
DOI
10.3390/nu12102907
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of Danio rerio
- (2020) Pragyan Paramita et al. DRUG AND CHEMICAL TOXICOLOGY
- The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK
- (2020) Nadya M. Morrow et al. JOURNAL OF LIPID RESEARCH
- Flavonoids as Anticancer Agents
- (2020) Dalia M. Kopustinskiene et al. Nutrients
- The Citrus Flavanone Hesperetin Induces Apoptosis in CTCL Cells via STAT3/Notch1/NFκB-Mediated Signaling Axis
- (2020) Amuthavalli Kottaiswamy et al. Anti-Cancer Agents in Medicinal Chemistry
- Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
- (2020) Habib Yaribeygi et al. Oxidative Medicine and Cellular Longevity
- Oxidative stress and diabetes: antioxidative strategies
- (2020) Pengju Zhang et al. Frontiers of Medicine
- Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health
- (2019) Ayman M. Mahmoud et al. Oxidative Medicine and Cellular Longevity
- Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death
- (2019) Yu-Ting Tseng et al. NUTRITIONAL NEUROSCIENCE
- Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways
- (2019) Shijie Liao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells
- (2019) Md Yousof Ali et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Benefits of Hesperidin for Cutaneous Functions
- (2019) Mao-Qiang Man et al. Evidence-based Complementary and Alternative Medicine
- Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells
- (2019) Yoshitaka Hosokawa et al. INFLAMMATION
- Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways
- (2019) Sun Hyo Jo et al. ARCHIVES OF PHARMACAL RESEARCH
- Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice
- (2019) Rika Tsuhako et al. Journal of Natural Medicines
- Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers
- (2019) Xuejun Zhang et al. Nutrition & Metabolism
- Neohesperidin suppresses IgE‐mediated anaphylactic reactions and mast cell activation via Lyn‐PLC‐Ca 2+ pathway
- (2019) Tingting Zhao et al. PHYTOTHERAPY RESEARCH
- Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention
- (2019) Goh et al. Cancers
- Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis
- (2019) Xinliang Chen et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice
- (2019) Kazunari Nohara et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis
- (2019) Yabing Wang et al. International Journal of Nanomedicine
- Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice
- (2019) Jiasen Guo et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death
- (2018) Kirtikar Shukla et al. BIOCHEMICAL PHARMACOLOGY
- Tangeretin inhibits high glucose-induced extracellular matrix accumulation in human glomerular mesangial cells
- (2018) Fang Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats
- (2018) Revathy Jayaraman et al. BIOMEDICINE & PHARMACOTHERAPY
- Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms
- (2018) John R. Petrie et al. CANADIAN JOURNAL OF CARDIOLOGY
- IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045
- (2018) N.H. Cho et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways
- (2018) Fan Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Escalation of liver malfunctioning: A step toward Herbal Awareness
- (2018) Bushra Sultana et al. JOURNAL OF ETHNOPHARMACOLOGY
- Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops
- (2018) et al. MOLECULES
- The effects of hesperidin and quercetin on serum tumor necrosis factor-alpha and interleukin-6 levels in streptozotocin-induced diabetes model
- (2018) Hatice Iskender et al. Pharmacognosy Magazine
- The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors
- (2018) Yoko Ohyama et al. PLoS One
- Naringin ameliorates endothelial dysfunction in fructose-fed rats
- (2018) Wachirawadee Malakul et al. Experimental and Therapeutic Medicine
- Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
- (2018) Chuan-Hao Jiang et al. Frontiers in Pharmacology
- Citrus peel polymethoxyflavones, sudachitin and nobiletin, induce distinct cellular responses in human keratinocyte HaCaT cells
- (2018) Shogo Abe et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Combating oxidative stress disorders with citrus flavonoid: Naringenin
- (2018) Nurul Hannim Zaidun et al. LIFE SCIENCES
- Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis
- (2018) Alireza Samie et al. LIFE SCIENCES
- Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro
- (2018) Won-Jae Kim et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
- Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin
- (2018) Qing Yao et al. MOLECULES
- The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function
- (2018) Amy Rees et al. Nutrients
- Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis
- (2017) AS Shalkami et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study
- (2017) Sara Zareei et al. LIFE SCIENCES
- Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice
- (2017) Zhen Tan et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The Anti-Inflammatory Properties of Citrus wilsonii Tanaka Extract in LPS-Induced RAW 264.7 and Primary Mouse Bone Marrow-Derived Dendritic Cells
- (2017) Liping Cheng et al. MOLECULES
- Diosmin, a Citrus Nutrient, Activates Imidazoline Receptors to Alleviate Blood Glucose and Lipids in Type 1-Like Diabetic Rats
- (2017) Chia-Chen Hsu et al. Nutrients
- Protective Effects of Hesperidin (Citrus Flavonone) on High Glucose Induced Oxidative Stress and Apoptosis in a Cellular Model for Diabetic Retinopathy
- (2017) Wayne Liu et al. Nutrients
- Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line
- (2017) R. Dhanya et al. Frontiers in Pharmacology
- Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model
- (2017) A. I. Carballo-Villalobos et al. INFLAMMOPHARMACOLOGY
- Characterization and Metabolic Diversity of Flavonoids in Citrus Species
- (2017) Shouchuang Wang et al. Scientific Reports
- Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects
- (2016) Raju Gautam et al. BMC Complementary and Alternative Medicine
- The Multifunctional Effects of Nobiletin and Its MetabolitesIn VivoandIn Vitro
- (2016) Hao Huang et al. Evidence-based Complementary and Alternative Medicine
- Naringin Protects Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma
- (2016) Xiong Guihua et al. INFLAMMATION
- Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy
- (2016) Ning Zhang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus
- (2016) Mohit Kwatra et al. NEUROCHEMICAL RESEARCH
- Therapeutic potential of naringin: an overview
- (2016) Rui Chen et al. PHARMACEUTICAL BIOLOGY
- Hybridization in Plants: Old Ideas, New Techniques
- (2016) Benjamin E. Goulet et al. PLANT PHYSIOLOGY
- Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways
- (2015) Yassine Chtourou et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Health-promoting effects of the citrus flavanone hesperidin
- (2015) Chaoyun Li et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Isoxanthohumol — Biologically active hop flavonoid
- (2015) Anna Katarzyna Żołnierczyk et al. FITOTERAPIA
- In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
- (2015) Ayman M. Mahmoud et al. International Journal of Diabetes in Developing Countries
- Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model
- (2015) Yu-Sheng Zhang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults
- (2015) Oscar D Rangel-Huerta et al. JOURNAL OF NUTRITION
- Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma
- (2015) Hao-yan Jiao et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Tangeretin, a polymethoxylated flavone, modulates lipid homeostasis and decreases oxidative stress by inhibiting NF-κB activation and proinflammatory cytokines in cardiac tissue of streptozotocin-induced diabetic rats
- (2015) Ramalingam Sundaram et al. Journal of Functional Foods
- Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice
- (2015) Sheng Jia et al. Food & Function
- Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches
- (2015) Suvi E. Heinonen et al. Journal of Diabetes Research
- Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity
- (2014) Hiroki Yoshida et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Anti-depressant effect of hesperidin in diabetic rats
- (2014) Salma A. El-Marasy et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines
- (2014) Sheikh Fayaz Ahmad et al. INFLAMMATION
- The pathobiology of diabetic vascular complications—cardiovascular and kidney disease
- (2014) Stephen P. Gray et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Role of naringenin in protection against diabetic hyperalgesia and tactile allodynia in male Wistar rats
- (2014) Parisa Hasanein et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Development of new reference material neohesperidin for quality control of dietary supplements
- (2014) Ningbo Gong et al. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
- Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle
- (2014) Rie Tsutsumi et al. Nutrition & Metabolism
- Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions
- (2014) Asjad Visnagri et al. PHARMACEUTICAL BIOLOGY
- Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction
- (2014) Anand Kamal Sachdeva et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats
- (2014) Ramalingam Sundaram et al. PHYTOMEDICINE
- Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action
- (2014) M. Ashraful Alam et al. Advances in Nutrition
- Antihyperlipidemic effect of diosmin: A citrus flavonoid on lipid metabolism in experimental diabetic rats
- (2013) Subramani Srinivasan et al. Journal of Functional Foods
- Diabetes and risk of physical disability in adults: a systematic review and meta-analysis
- (2013) Evelyn Wong et al. Lancet Diabetes & Endocrinology
- Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells
- (2012) Gon-Sup Kim et al. BMC Complementary and Alternative Medicine
- Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy
- (2012) Amit D. Kandhare et al. FITOTERAPIA
- Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells
- (2012) Jiukai Zhang et al. FOOD CHEMISTRY
- Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats
- (2012) Mehrdad Roghani et al. INDIAN JOURNAL OF PHARMACOLOGY
- Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats
- (2012) Ayman M. Mahmoud et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability
- (2012) Andreia F. M. Furtado et al. JOURNAL OF MOLECULAR RECOGNITION
- Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice
- (2012) Young-Sil Lee et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Polymethoxyflavonoids Tangeretin and Nobiletin Increase Glucose Uptake in Murine Adipocytes
- (2012) Kenji Onda et al. PHYTOTHERAPY RESEARCH
- Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction
- (2011) Kota Kanda et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Didymin Induces Apoptosis by Inhibiting N-Myc and Upregulating RKIP in Neuroblastoma
- (2011) J. Singhal et al. Cancer Prevention Research
- Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance
- (2011) E. E. Mulvihill et al. DIABETES
- Analysis of genetic diversity in Citrus
- (2011) François Luro et al. Plant Genetic Resources-Characterization and Utilization
- Two new c-glucosyl benzoic acids and flavonoids from Mallotus nanus and their antioxidant activity
- (2010) Phan Van Kiem et al. ARCHIVES OF PHARMACAL RESEARCH
- Polymethoxylated Flavones, Flavanone Glycosides, Carotenoids, and Antioxidants in Different Cultivation Types of Tangerines (Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand
- (2010) Wolfgang Stuetz et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Angiogenesis and Inflammation Signaling Are Targets of Beer Polyphenols on Vascular Cells
- (2010) Rita Negrão et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Dietary Hesperidin Exerts Hypoglycemic and Hypolipidemic Effects in Streptozotocin-Induced Marginal Type 1 Diabetic Rats
- (2010) Satoko Akiyama et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: Potential prophylactic ingredients for functional foods application
- (2010) Deena Ramful et al. TOXICOLOGY
- Influence of rutin treatment on biochemical alterations in experimental diabetes
- (2009) Ana Angélica Henrique Fernandes et al. BIOMEDICINE & PHARMACOTHERAPY
- Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated fromCitrus grandis(L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells
- (2009) Yerra Koteswara Rao et al. Evidence-based Complementary and Alternative Medicine
- Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant
- (2009) Garima Vij et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo
- (2009) Jen-Yu Hung et al. LUNG CANCER
- Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
- (2009) David Moher et al. PLOS MEDICINE
- Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells
- (2008) Sam-Long Hwang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Influence of l-rhamnosyl-d-glucosyl derivatives on properties and biological interaction of flavonoids
- (2008) Ersilia Bellocco et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Dietary Flavonoid Sources in Australian Adults
- (2008) Shawn M. Somerset et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started