Review
Medicine, Research & Experimental
Jiawei Feng, Yichen Yao, Qixue Wang, Xiaozhou Han, Xiaofei Deng, Yemin Cao, Xinghua Chen, Mingmei Zhou, Cheng Zhao
Summary: Diabetic wounds, especially in the foot, are difficult to heal due to various factors such as infection, trauma, neuropathy, and vascular disease. The pathogenesis and clinical manifestations of diabetic wounds are complicated, and there is a lack of objective laboratory diagnosis and classification standards. Exosomes, containing various molecular components, play a crucial role in vascular regeneration, tissue repair, and inflammation regulation during the healing process of diabetic wounds.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Surgery
Iliya Goldberg, Lizhou Nie, Jie Yang, Salvatore Docimo, Silvana Obici, Mark Talamini, Aurora Pryor, Konstantinos Spaniolas
Summary: This study assessed the development of microvascular and macrovascular complications in obese DM patients undergoing bariatric surgery, showing that surgery patients had significantly lower risk of both microvascular and macrovascular complications compared to non-surgery patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Cardiac & Cardiovascular Systems
Bao Sun, Zhiying Luo, Jiecan Zhou
Summary: Glycemic variability (GV) is recognized as a possible independent risk factor for diabetic complications, with this review summarizing the metrics and measurement of GV in clinical practice and elaborating its role and related mechanisms in both macrovascular and microvascular complications of diabetes to provide mechanism-based therapeutic strategies for clinicians.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Endocrinology & Metabolism
Ziyan Xie, Xinhua Xiao
Summary: This paper reviews the recent advancements in novel biomarkers, artificial intelligence technology, therapeutic agents, and approaches for diabetic retinopathy and nephropathy, providing valuable insights into the management of microvascular complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tsuyoshi Nakai, Kiyofumi Yamada, Hiroyuki Mizoguchi
Summary: Alzheimer's disease is an age-related and progressive neurodegenerative disorder mainly caused by the accumulation of Aβ and tau. Despite various AD mouse models developed, none fully replicate all pathologies present in human AD. APP knock-in mice may offer a better evaluation of candidate therapeutics in early-stage AD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Review
Cell Biology
Kevin Park, Mysore S. Veena, Daniel Sanghoon Shin
Summary: The tumor microenvironment is a battlefield for immune cells and tumor cells, and immune checkpoint inhibitors have shown promise in cancer treatment. However, response rates are low and resistance is common. Understanding the tumor microenvironment is crucial for developing strategies to overcome resistance, and ongoing clinical trials are investigating combination treatments targeting specific tumor and microenvironment characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Gisela Gaina, Alexandra Popa (Gruianu)
Summary: Muscular dystrophies are a group of genetically inherited diseases characterized by muscle weakness and wasting, with no effective treatment currently available. In recent years, several novel therapeutic approaches have been developed, including restoring protein expression and genetically engineered animal models.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Cell Biology
Zhun Yu, JinZhu Yin, ZhiTong Tang, Ting Hu, ZhuoEr Wang, Ying Chen, Tianjia Liu, Wei Zhang
Summary: Cardiovascular disease is the leading cause of death in humans, with atherosclerosis being the most common type. Noncoding RNAs play a crucial role in the development of atherosclerosis and have potential as diagnostic markers and therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Bridget Martinez, Philip Peplow
Summary: A review of recent animal models of amyotrophic lateral sclerosis revealed altered expression levels of numerous miRNAs in various parts of the nervous system, with a majority being upregulated. Suppression or overexpression of specific miRNAs showed potential for increasing lifespan, improving muscle strength, and enhancing motor neuron survival in SOD1(G93A) animals. Further studies are needed to validate these findings and identify miRNAs that could be targeted for therapeutic purposes.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yu Cao, Qianqian Chen, Yinai Liu, Libo Jin, Renyi Peng
Summary: Diabetes is a metabolic disease with high blood glucose levels, and its prevalence has been increasing due to economic development and lifestyle changes. The use of diabetic animal models, such as zebrafish, has proven helpful for studying the pathogenesis of diabetes and drug development. This review summarizes the advantages of zebrafish as a diabetes model and the construction methods and challenges of zebrafish models for type 1 diabetes, type 2 diabetes, and diabetes complications. The study provides valuable reference information for further research on the pathological mechanisms of diabetes and the development of new therapeutic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lidia Puertas-Umbert, Judith Alonso, Leif Hove-Madsen, Jose Martinez-Gonzalez, Cristina Rodriguez
Summary: This review summarizes the role of the PDE4 subfamily in cardiovascular function and highlights the challenges associated with targeting PDE4 enzymes as a therapeutic strategy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Zhan Zhang, Ying Zhang, Dan Yang, Yue Luo, Ying Luo, Yi Ru, Jiankun Song, Xiaoya Fei, Yiran Chen, Bin Li, Jingsi Jiang, Le Kuai
Summary: This study investigates the pathogenesis of diabetic ulcers using weighted gene co-expression network analysis and validates the function of important genes through animal experiments. The results demonstrate that these genes are closely related to immune response and play a crucial role in diabetic ulcers.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Dermatology
Yuqing Du, Jie Wang, Weijing Fan, Renyan Huang, Hongfei Wang, Guobin Liu
Summary: Diabetic foot ulcer is a common chronic complication of diabetes mellitus, with a prevalence of 25% and a significant risk of amputation or death. Vascular risk factors, impaired neurosensory and motor function, and skin infection all contribute to the development of DFU in patients with diabetes.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, Research & Experimental
Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Praveen Thaggikuppe Krishnamurthy, Veera Venkata Satyanarayana Reddy Karri
Summary: The treatment of diabetic wounds presents complex challenges due to multifaceted pathophysiology, requiring appropriate animal models for study. While various animal models have been developed to examine wound healing processes, many lack the ability to properly replicate human diabetic wounds. Therefore, the major future challenge lies in developing a model that closely resembles the human diabetic wound environment in order to advance translational research in wound care.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Amra Jujic, Peter M. Nilsson, Naeimeh Atabaki-Pasdar, Anna Dieden, Tiinamaija Tuomi, Paul W. Franks, Jens Juul Holst, Signe Sorensen Torekov, Susana Ravassa, Javier Diez, Margaretha Persson, Emma Ahlqvist, Olle Melander, Maria F. Gomez, Leif Groop, Martin Magnusson
Summary: This study revealed that elevated fasting GIP levels are associated with increased IMTmeanCCA, while GLP-1 levels are associated with decreased IMTmaxBulb in an elderly Swedish population, highlighting diverging cardiovascular effects of these two incretin hormones.
Article
Public, Environmental & Occupational Health
Thomas Varsavsky, Mark S. Graham, Liane S. Canas, Sajaysurya Ganesh, Joan Capdevila Pujol, Carole H. Sudre, Benjamin Murray, Marc Modat, M. Jorge Cardoso, Christina M. Astley, David A. Drew, Long H. Nguyen, Tove Fall, Maria F. Gomez, Paul W. Franks, Andrew T. Chan, Richard Davies, Jonathan Wolf, Claire J. Steves, Tim D. Spector, Sebastien Ourselin
Summary: This study used data from users of the COVID Symptom Study app in England to track COVID-19 cases and epidemic trends, highlighting the importance of local-level disease tracking without reimposing national restrictions. By utilizing self-reported data, policymakers can gain insights into the pandemic and take targeted measures in a timely manner.
LANCET PUBLIC HEALTH
(2021)
Correction
Cardiac & Cardiovascular Systems
Pratibha Singh, Isabel Goncalves, Christofer Tengryd, Mihaela Nitulescu, Ana F. Persson, Fong To, Eva Bengtsson, Petr Volkov, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeldt
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carole H. Sudre, Benjamin Murray, Thomas Varsavsky, Mark S. Graham, Rose S. Penfold, Ruth C. Bowyer, Joan Capdevila Pujol, Kerstin Klaser, Michela Antonelli, Liane S. Canas, Erika Molteni, Marc Modat, M. Jorge Cardoso, Anna May, Sajaysurya Ganesh, Richard Davies, Long H. Nguyen, David A. Drew, Christina M. Astley, Amit D. Joshi, Jordi Merino, Neli Tsereteli, Tove Fall, Maria F. Gomez, Emma L. Duncan, Cristina Menni, Frances M. K. Williams, Paul W. Franks, Andrew T. Chan, Jonathan Wolf, Sebastien Ourselin, Tim Spector, Claire J. Steves
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Article
Endocrinology & Metabolism
Kari Anne Sveen, Kristine Bech Holte, Mona Svanteson, Kristian F. Hanssen, Jan Nilsson, Eva Bengtsson, Tore Julsrud Berg
Summary: In type 1 diabetes, autoantibodies against AGE-modified apoB100 are inversely associated with coronary atherosclerosis and proliferative retinopathy, indicating a vascular protective effect of these autoantibodies.
Article
Medicine, General & Internal
S. Holm Nielsen, A. Edsfeldt, C. Tengryd, H. Gustafsson, A. C. Shore, A. Natali, F. Khan, F. Genovese, E. Bengtsson, M. Karsdal, D. J. Leeming, J. Nilsson, I Goncalves
Summary: The study found that PRO-C6 can be localized in atherosclerotic plaques, and it is predictive of future cardiovascular events, cardiovascular death, and all-cause mortality.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Erika Molteni, Christina M. Astley, Wenjie Ma, Carole H. Sudre, Laura A. Magee, Benjamin Murray, Tove Fall, Maria F. Gomez, Neli Tsereteli, Paul W. Franks, John S. Brownstein, Richard Davies, Jonathan Wolf, Tim D. Spector, Sebastien Ourselin, Claire J. Steves, Andrew T. Chan, Marc Modat
Summary: This study compared the symptom profile and severity of COVID-19 in pregnant and non-pregnant women, finding no significant differences in overall severity but a higher likelihood of testing in pregnant women. Additionally, it was found that lung disease and diabetes were associated with increased risk of more severe viral infection during pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Neha Sharma, Chandran Nagaraj, Bence M. Nagy, Leigh M. Marsh, Natalie Bordag, Diana Zabini, Malgorzata Wygrecka, Walter Klepetko, Elisabeth Gschwandtner, Guillem Genove, Akos Heinemann, E. Kenneth Weir, Grazyna Kwapiszewska, Horst Olschewski, Andrea Olschewski
Summary: RGS5 plays a role in allergic pulmonary diseases, and its loss can preserve lung function and attenuate hyperinflammation in the short term, particularly in bleomycin-induced pulmonary fibrosis and LPS-induced lung injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Kari Anne Sveen, Gustav Smith, Harry Bjorkbacka, Marju Orho-Melander, Gunnar Engstrom, Isabel Goncalves, Olle Melander, Jan Nilsson, Eva Bengtsson
Summary: This study found an association between autoantibodies against oxidized apolipoprotein B100 peptides and incidence of atrial fibrillation in a large population-based cohort. Women had higher levels of IgM against native apolipoprotein B100 peptides than men, and the association between IgM against native p210 and AF differed significantly between sexes.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Marie Pigeyre, Sibylle Hess, Maria F. Gomez, Olof Asplund, Leif Groop, Guillaume Pare, Hertzel Gerstein
Summary: Cluster analysis identified five subtypes of diabetes in a multiethnic cohort, showing variations in renal outcomes and response to insulin among different subtypes. These findings highlight the importance of precision medicine in predicting comorbidities and treatment responses for individuals with diabetes.
Article
Urology & Nephrology
Katja Moller-Hackbarth, Dina Dabaghie, Emmanuelle Charrin, Sonia Zambrano, Guillem Genove, Xidan Li, Annika Wernerson, Mark Lal, Jaakko Patrakka
Summary: Inflammatory pathways are activated in most glomerular diseases, with the induction of Rarres1 expression being a common molecular mechanism in chronic kidney diseases. The overexpression of Rarres1 in endothelial cells promotes kidney damage in a model of glomerulonephritis through the Nuclear Factor-kappa B signaling pathway, highlighting its pathogenic role in inflammation and fibrosis.
KIDNEY INTERNATIONAL
(2021)
Article
Clinical Neurology
Isabel Goncalves, Loureen Oduor, Frank Matthes, Narjess Rakem, Jakob Meryn, Nikolaos-Taxiarchis Skenteris, Anders Aspberg, Marju Orho-Melander, Jan Nilsson, Ljubica Matic, Andreas Edsfeldt, Jiangming Sun, Eva Bengtsson
Summary: This study found that the expression of osteomodulin in human atherosclerotic plaques is associated with plaque calcification and plaque stability.
Article
Oncology
Nikolaos T. Skenteris, Till Seime, Anna Witasp, Eva Karlof, Grzegorz B. Wasilewski, Marina A. Heuschkel, Armand M. G. Jaminon, Loureen Oduor, Robert Dzhanaev, Malin Kronqvist, Mariette Lengquist, Frederique E. C. M. Peeters, Magnus Soderberg, Rebecka Hultgren, Joy Roy, Lars Maegdefessel, Hildur Arnardottir, Eva Bengtsson, Isabel Goncalves, Thomas Quertermous, Claudia Goettsch, Peter Stenvinkel, Leon J. Schurgers, Ljubica Matic
Summary: Recent studies have found a correlation between plasma and tissue levels of osteomodulin (OMD) and cardiovascular calcification, suggesting the potential of OMD as a clinical biomarker. OMD was found to be present in calcified cardiovascular tissues and was induced by pro-inflammatory and pro-osteogenic stimuli. Furthermore, the presence of OMD in the extracellular environment attenuated smooth muscle cell (SMC) calcification.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Beatrice Kennedy, Hugo Fitipaldi, Ulf Hammar, Marlena Maziarz, Neli Tsereteli, Nikolay Oskolkov, Georgios Varotsis, Camilla A. Franks, Diem Nguyen, Lampros Spiliopoulos, Hans-Olov Adami, Jonas Bjork, Stefan Engblom, Katja Fall, Anna Grimby-Ekman, Jan-Eric Litton, Mats Martinell, Anna Oudin, Torbjorn Sjostrom, Toomas Timpka, Carole H. Sudre, Mark S. Graham, Julien Lavigne du Cadet, Andrew T. Chan, Richard Davies, Sajaysurya Ganesh, Anna May, Sebastien Ourselin, Joan Capdevila Pujol, Somesh Selvachandran, Jonathan Wolf, Tim D. Spector, Claire J. Steves, Maria F. Gomez, Paul W. Franks, Tove Fall
Summary: The app-based COVID Symptom Study in Sweden utilized daily symptom reports to create a model for estimating the probability of symptomatic COVID-19 and predicting hospital admissions. The model showed lower prediction errors compared to a model based on case notifications and demonstrated transferability when applied to an English dataset.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Carl Bonander, Debora Stranges, Johanna Gustavsson, Matilda Almgren, Malin Inghammar, Mahnaz Moghaddassi, Anton Nilsson, Joan Capdevila Pujol, Claire Steves, Paul W. Franks, Maria F. Gomez, Tove Fall, Jonas Bjork
Summary: This study investigates the impact of a non-mandatory and age-specific social distancing recommendation on isolation behaviors and disease outcomes in Sweden during the first wave of the COVID-19 pandemic. The results suggest that the age-specific recommendations helped control COVID-19 disease, preventing severe cases.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)