The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Role of reactive oxygen species-mediated MAPK and NF-κB activation inpolygonatum cyrtonemalectin-induced apoptosis and autophagy in human lung adenocarcinoma A549 cells

(2016) Tao Liu et al.   JOURNAL OF BIOCHEMISTRY

Protective Effects of Green Tea Polyphenol Against Renal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats

(2016) Haidong Wang et al.   MOLECULES AND CELLS

Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state

(2015) Mai Nakayachi et al.   BONE

Osteocytes Produce Interferon-β as a Negative Regulator of Osteoclastogenesis

(2014) Chiyomi Hayashida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights Into the Pharmacological Potential of Plant Flavonoids in the Catecholamine System

(2014) Nobuyuki Yanagihara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle

(2014) Rie Tsutsumi et al.   Nutrition & Metabolism

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control

(2014) Eun-Ji Yang et al.   PLoS One

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

(2013) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Sudachitin, a Polymethoxyflavone fromCitrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

(2012) Keizo YUASA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

(2012) Tsukasa Tominari et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Naturally Plant-Derived Compounds: Role in Bone Anabolism

(2012) Marie-Noelle Horcajada et al.   Current Molecular Pharmacology

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

(2011) Suguru Harada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

(2011) Yoshiomi Oka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial

(2011) Matthew R Smith et al.   LANCET

ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss

(2010) Taesoo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

(2010) Young-Sil Lee et al.   BIOCHEMICAL PHARMACOLOGY

RANKL-mediated Reactive Oxygen Species Pathway That Induces Long Lasting Ca2+Oscillations Essential for Osteoclastogenesis

(2010) Min Seuk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk factors for hip fracture in european women: The MEDOS study

(2010) Olof Johnell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ascorbic acid accelerates osteoclast formation and death

(2009) Damien Le Nihouannen et al.   BONE

New aspects of adipogenesis: Radicals and oxidative stress

(2009) Caroline Gummersbach et al.   DIFFERENTIATION

Trolox Prevents Osteoclastogenesis by Suppressing RANKL Expression and Signaling

(2009) Jong-Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin-3-gallate Inhibits Osteoclastogenesis by Down-Regulating c-Fos Expression and Suppressing the Nuclear Factor- B Signal

(2009) J.-H. Lee et al.   MOLECULAR PHARMACOLOGY