Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes

Viral degradasome hijacks mitochondria to suppress innate immunity

(2013) Ramansu Goswami et al.   CELL RESEARCH

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

(2013) Mian Zhou et al.   NATURE

Respiratory Syncytial Virus-Associated Hospitalizations Among Children Less Than 24 Months of Age

(2013) C. B. Hall et al.   PEDIATRICS

Safety and Immunogenicity of a Live Attenuated RSV Vaccine in Healthy RSV-Seronegative Children 5 to 24 Months of Age

(2013) Elissa Malkin et al.   PLoS One

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice

(2013) Chen Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Respiratory Syncytial Virus Modified by Deletions of the NS2 Gene and Amino Acid S1313 of the L Polymerase Protein Is a Temperature-Sensitive, Live-Attenuated Vaccine Candidate That Is Phenotypically Stable at Physiological Temperature

(2012) C. Luongo et al.   JOURNAL OF VIROLOGY

The Human Respiratory Syncytial Virus Nonstructural Protein 1 Regulates Type I and Type II Interferon Pathways

(2012) Marcus L. Hastie et al.   MOLECULAR & CELLULAR PROTEOMICS

NF-κB as a potential therapeutic target in microbial diseases

(2012) Mariateresa Vitiello et al.   Molecular BioSystems

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

(2012) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis

(2012) Anne L. Hotard et al.   VIROLOGY

Balanced Codon Usage Optimizes Eukaryotic Translational Efficiency

(2012) Wenfeng Qian et al.   PLoS Genetics

Multiple Functional Domains and Complexes of the Two Nonstructural Proteins of Human Respiratory Syncytial Virus Contribute to Interferon Suppression and Cellular Location

(2011) S. Swedan et al.   JOURNAL OF VIROLOGY

Both Nonstructural Proteins NS1 and NS2 of Pneumonia Virus of Mice are Inhibitors of the Interferon Type I and Type III Responses In Vivo

(2011) B. Heinze et al.   JOURNAL OF VIROLOGY

Differential Pathogenesis of Respiratory Syncytial Virus Clinical Isolates in BALB/c Mice

(2011) K. L. Stokes et al.   JOURNAL OF VIROLOGY

Respiratory Syncytial Virus-associated Hospitalizations Among Infants and Young Children in the United States, 1997–2006

(2011) Lauren J. Stockman et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years

(2011) Peter L. Collins et al.   VIRUS RESEARCH

Respiratory Syncytial Virus Interferon Antagonist NS1 Protein Suppresses and Skews the Human T Lymphocyte Response

(2011) Shirin Munir et al.   PLoS Pathogens

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

Biological challenges and technological opportunities for respiratory syncytial virus vaccine development

(2010) Barney S. Graham   IMMUNOLOGICAL REVIEWS

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

Human Respiratory Syncytial Virus Nonstructural Protein NS2 Antagonizes the Activation of Beta Interferon Transcription by Interacting with RIG-I

(2009) Z. Ling et al.   JOURNAL OF VIROLOGY

Respiratory Syncytial Virus Nonstructural Proteins Decrease Levels of Multiple Members of the Cellular Interferon Pathways

(2009) S. Swedan et al.   JOURNAL OF VIROLOGY

Universal function-specificity of codon usage

(2009) Hamed Shateri Najafabadi et al.   NUCLEIC ACIDS RESEARCH

Selection on Codon Bias

(2008) Ruth Hershberg et al.   Annual Review of Genetics

Nonstructural Proteins 1 and 2 of Respiratory Syncytial Virus Suppress Maturation of Human Dendritic Cells

(2008) S. Munir et al.   JOURNAL OF VIROLOGY

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE