TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3

(2011) Gillian M. Tannahill et al.   FEBS LETTERS

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1  Secretion by Activating the NLRP3 Inflammasome

(2011) R. Allam et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Inflammasome in Atherosclerosis and Type 2 Diabetes

(2011) S. L. Masters et al.   Science Translational Medicine

Coupled Nucleotide and Mucin Hypersecretion from Goblet-Cell Metaplastic Human Airway Epithelium

(2010) Seiko F. Okada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Sensing and Signaling in Antiviral Innate Immunity

(2010) Luke A.J. O'Neill et al.   CURRENT BIOLOGY

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes and Anti-Viral Immunity

(2010) Vijay A. K. Rathinam et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF- B Signaling

(2010) C. Toma et al.   JOURNAL OF IMMUNOLOGY

(1,3)- -Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

(2010) P. Kankkunen et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Anticancer oncolytic activity of respiratory syncytial virus

(2009) I Echchgadda et al.   CANCER GENE THERAPY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Inflammasome-dependent Caspase-1 Activation in Cervical Epithelial Cells Stimulates Growth of the Intracellular PathogenChlamydia trachomatis

(2009) Ali A. Abdul-Sater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab39a Binds Caspase-1 and Is Required for Caspase-1-dependent Interleukin-1β Secretion

(2009) Christine E. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

(2009) S. Jha et al.   JOURNAL OF IMMUNOLOGY

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

(2009) Joseph A. Duncan et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Bypassing Pathogen‐Induced Inflammasome Activation for the Regulation of Interleukin‐1β Production by the Fungal PathogenCandida albicans

(2009) Frank L. van de Veerdonk et al.   JOURNAL OF INFECTIOUS DISEASES

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

(2009) Jessica Chu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

(2009) Radhashree Maitra et al.   MOLECULAR IMMUNOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

(2009) Julie Delaloye et al.   PLoS Pathogens

The Inflammasomes

(2009) Mohamed Lamkanfi et al.   PLoS Pathogens

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

(2008) Zhengmao Ye et al.   CURRENT OPINION IN IMMUNOLOGY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Role of Human β-Defensin-2 during Tumor Necrosis Factor-α/NF-κB-mediated Innate Antiviral Response against Human Respiratory Syncytial Virus

(2008) Srikanth Kota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2

(2008) M. R. Murawski et al.   JOURNAL OF VIROLOGY

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE