Respiratory syncytial virus vaccine development

Challenges in developing a pediatric RSV vaccine

(2014) Jeanne H. Schickli et al.   Human vaccines & immunotherapeutics

Macrophage Dysfunction and Susceptibility to Pulmonary Pseudomonas aeruginosa Infection in Surfactant Protein C-Deficient Mice

(2014) S. W. Glasser et al.   JOURNAL OF IMMUNOLOGY

A chemically defined production process for highly attenuated poxviruses

(2011) Ingo Jordan et al.   BIOLOGICALS

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Activation of Antigen-Specific T Cell-Responses by Mannan-Decorated PLGA Nanoparticles

(2011) Samar Hamdy et al.   PHARMACEUTICAL RESEARCH

Chlamydia pneumoniae Infection Induced Allergic Airway Sensitization Is Controlled by Regulatory T-Cells and Plasmacytoid Dendritic Cells

(2011) Timothy R. Crother et al.   PLoS One

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

(2011) K. A. Swanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypes and functions of persistent Sendai virus-induced antibody forming cells and CD8+ T cells in diffuse nasal-associated lymphoid tissue typify lymphocyte responses of the gut

(2011) Rajeev Rudraraju et al.   VIROLOGY

Clearance of HIV Type 1 Envelope Recombinant Sendai Virus Depends on CD4+ T Cells and Interferon-γ But Not B Cells, CD8+ T Cells, or Perforin

(2010) Sherri L. Surman et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A prime–boost vaccination strategy using attenuated Salmonella typhimurium and a replication-deficient recombinant adenovirus vector elicits protective immunity against human respiratory syncytial virus

(2010) Yuan-Hui Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study

(2010) Michelle L. Butt et al.   EUROPEAN JOURNAL OF PEDIATRICS

Prospects for defined epitope vaccines for respiratory syncytial virus

(2010) Robert Anderson et al.   Future Microbiology

Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells

(2010) Avidan U. Neumann et al.   HEPATOLOGY

New insights for development of a safe and protective RSV vaccine

(2010) Jorge C. G. Blanco et al.   Human vaccines & immunotherapeutics

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Biological challenges and technological opportunities for respiratory syncytial virus vaccine development

(2010) Barney S. Graham   IMMUNOLOGICAL REVIEWS

The Role of Respiratory Virus Infections in Childhood Asthma Inception

(2010) Daniel J. Jackson et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children

(2010) Eric A.F. Simões et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TCR Revision Generates Functional CD4+ T Cells

(2010) J. S. Hale et al.   JOURNAL OF IMMUNOLOGY

Efficient Lung Recruitment of Respiratory Syncytial Virus-Specific Th1 Cells Induced by Recombinant Bacillus Calmette-Guerin Promotes Virus Clearance and Protects from Infection

(2010) K. M. Cautivo et al.   JOURNAL OF IMMUNOLOGY

Immunomodulation with IL-4R  Antisense Oligonucleotide Prevents Respiratory Syncytial Virus-Mediated Pulmonary Disease

(2010) M. J. Ripple et al.   JOURNAL OF IMMUNOLOGY

Tumor Infiltrating Lymphocyte Therapy for Metastatic Melanoma: Analysis of Tumors Resected for TIL

(2010) Stephanie L. Goff et al.   JOURNAL OF IMMUNOTHERAPY

Transgenic apple expressing an antigenic protein of the human respiratory syncytial virus

(2010) Joann M. Lau et al.   JOURNAL OF PLANT PHYSIOLOGY

CD25+ Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection

(2010) D. C. P. Lee et al.   JOURNAL OF VIROLOGY

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

(2010) J. S. McLellan et al.   JOURNAL OF VIROLOGY

Prophylactic Treatment with a G Glycoprotein Monoclonal Antibody Reduces Pulmonary Inflammation in Respiratory Syncytial Virus (RSV)-Challenged Naive and Formalin-Inactivated RSV-Immunized BALB/c Mice

(2010) G. U. Radu et al.   JOURNAL OF VIROLOGY

Assembly and Immunological Properties of Newcastle Disease Virus-Like Particles Containing the Respiratory Syncytial Virus F and G Proteins

(2010) L. W. McGinnes et al.   JOURNAL OF VIROLOGY

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination

(2010) B S Graham et al.   Mucosal Immunology

Structural basis of respiratory syncytial virus neutralization by motavizumab

(2010) Jason S McLellan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elicitation of structure-specific antibodies by epitope scaffolds

(2010) G. Ofek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipopeptide-adjuvanted respiratory syncytial virus virosomes: A safe and immunogenic non-replicating vaccine formulation

(2010) Toon Stegmann et al.   VACCINE

Single mucosal immunization of recombinant adenovirus-based vaccine expressing F1 protein fragment induces protective mucosal immunity against respiratory syncytial virus infection

(2010) Sol Kim et al.   VACCINE

Robust IgA and IgG-producing antibody forming cells in the diffuse-NALT and lungs of Sendai virus-vaccinated cotton rats associate with rapid protection against human parainfluenza virus-type 1

(2010) R. Sealy et al.   VACCINE

A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats

(2010) Myra N Widjojoatmodjo et al.   Virology Journal

Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials

(2010) Scott A. Brown et al.   Viruses-Basel

Respiratory viruses and eosinophils: Exploring the connections

(2009) Helene F. Rosenberg et al.   ANTIVIRAL RESEARCH

The cotton rat model of respiratory viral infections

(2009) Marina S. Boukhvalova et al.   BIOLOGICALS

Risk Factors for Respiratory Failure Associated with Respiratory Syncytial Virus Infection in Adults

(2009) Coley B. Duncan et al.   JOURNAL OF INFECTIOUS DISEASES

Seasonal Variation of Maternally Derived Respiratory Syncytial Virus Antibodies and Association with Infant Hospitalizations for Respiratory Syncytial Virus

(2009) Lone Graff Stensballe et al.   JOURNAL OF PEDIATRICS

Newcastle Disease Virus-Like Particles Containing Respiratory Syncytial Virus G Protein Induced Protection in BALB/c Mice, with No Evidence of Immunopathology

(2009) M. R. Murawski et al.   JOURNAL OF VIROLOGY

Antibody affinity maturation and respiratory syncytial virus disease

(2009) Christine A Shaw et al.   NATURE MEDICINE

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenicity of the 10-Valent Pneumococcal Non-typeable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV) Compared to the Licensed 7vCRM Vaccine

(2009) Timo Vesikari et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

A 3-D Well-Differentiated Model of Pediatric Bronchial Epithelium Demonstrates Unstimulated Morphological Differences Between Asthmatic and Nonasthmatic Cells

(2009) Jeremy Parker et al.   PEDIATRIC RESEARCH

Relative Impact of Influenza and Respiratory Syncytial Virus in Young Children

(2009) F. T. Bourgeois et al.   PEDIATRICS

Trends in early childhood vaccination coverage: Progress towards US Healthy People 2010 goals

(2009) Zhen Zhao et al.   VACCINE

Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity

(2009) Lindvi Gudmundsdotter et al.   VACCINE

Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-2, hPIV-3, and RSV

(2009) Bart Jones et al.   VACCINE

Codon stabilization analysis of the “248” temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates

(2009) Cindy Luongo et al.   VACCINE

A dose-ranging study of a subunit Respiratory Syncytial Virus subtype A vaccine with and without aluminum phosphate adjuvantation in adults ≥65 years of age

(2009) Joanne M. Langley et al.   VACCINE

Pulmonary Eosinophilia Is Attenuated by Early Responding CD8+ Memory T Cells in a Murine Model of RSV Vaccine-Enhanced Disease

(2009) Whitney W. Stevens et al.   VIRAL IMMUNOLOGY

RSV fusion (F) protein DNA vaccine provides partial protection against viral infection

(2009) Hongzhuan Wu et al.   VIRUS RESEARCH

Nanoparticle vaccines against respiratory viruses

(2009) Brian M. Adair   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Fc receptor-mediated antiviral antibodies

(2009) Donald N Forthal et al.   Current Opinion in HIV and AIDS

Electrocardiography Screening for Cardiotoxicity after Modified Vaccinia Ankara Vaccination

(2008) Junko Sano et al.   AMERICAN JOURNAL OF MEDICINE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Target Peptide Sequence within Infectious Human Immunodeficiency Virus Type 1 Does Not Ensure Envelope-Specific T-Helper Cell Reactivation: Influences of Cysteine Protease and Gamma Interferon-Induced Thiol Reductase Activities

(2008) R. Sealy et al.   Clinical and Vaccine Immunology

Rearrangement of Mouse Immunoglobulin Kappa Deleting Element Recombining Sequence Promotes Immune Tolerance and Lambda B Cell Production

(2008) José Luis Vela et al.   IMMUNITY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

(2008) Susanne Herold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety and Immunogenicity of a New Tuberculosis Vaccine, MVA85A, in Healthy Adults in South Africa

(2008) Tony Hawkridge et al.   JOURNAL OF INFECTIOUS DISEASES

Comparison of the Safety and Immunogenicity of 2 Respiratory Syncytial Virus (RSV) Vaccines— Nonadjuvanted Vaccine or Vaccine Adjuvanted with Alum—Given Concomitantly with Influenza Vaccine to High‐Risk Elderly Individuals

(2008) Ann R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

The Secreted Form of Respiratory Syncytial Virus G Glycoprotein Helps the Virus Evade Antibody-Mediated Restriction of Replication by Acting as an Antigen Decoy and through Effects on Fc Receptor-Bearing Leukocytes

(2008) A. Bukreyev et al.   JOURNAL OF VIROLOGY

FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

(2008) Wanzhong He et al.   NATURE

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE

Risk Factors for Severe Respiratory Syncytial Virus Disease in Children With Cancer: The Importance of Lymphopenia and Young Age

(2008) C. M. El Saleeby et al.   PEDIATRICS

Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain

(2008) Siok Wan Gan et al.   PROTEIN SCIENCE

Development of a PIV-vectored RSV vaccine: Preclinical evaluation of safety, toxicity, and enhanced disease and initial clinical testing in healthy adults

(2008) Roderick S. Tang et al.   VACCINE

Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections

(2008) Xiaoyan Zhan et al.   VACCINE