Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking

Reduced glutathione biosynthesis inDrosophila melanogastercauses neuronal defects linked to copper deficiency

(2016) Stephen W. Mercer et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

(2016) Yuta Hatori et al.   Nature Communications

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1

(2015) Shweta Jain et al.   MOLECULAR BIOLOGY OF THE CELL

Glutaredoxin1 protects neuronal cells from copper-induced toxicity

(2014) Michael A. Cater et al.   BIOMETALS

Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

(2014) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Glutathione System: A New Drug Target in Neuroimmune Disorders

(2014) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

DKWSLLL, a Versatile DXXXLL-Type Signal with Distinct Roles in the Cu+-Regulated Trafficking of ATP7B

(2014) Vasiliki Lalioti et al.   TRAFFIC

Copper: from neurotransmission to neuroproteostasis

(2014) Carlos M. Opazo et al.   Frontiers in Aging Neuroscience

Glutathione depletion in survival and apoptotic pathways

(2014) Milena De Nicola et al.   Frontiers in Pharmacology

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1

(2013) Edward B. Maryon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inorganic Stressors of Ubiquitin

(2013) Giuseppe Arena et al.   INORGANIC CHEMISTRY

Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2–, AP-1–, and Rab22-dependent steps

(2013) Zoe G. Holloway et al.   MOLECULAR BIOLOGY OF THE CELL

Presenilin Promotes Dietary Copper Uptake

(2013) Adam Southon et al.   PLoS One

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional Partnership of the Copper Export Machinery and Glutathione Balance in Human Cells

(2012) Yuta Hatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Impact of Copper Limitation on Expression and Function of Multicopper Oxidases (Ferroxidases)

(2012) Joseph R. Prohaska   Advances in Nutrition

Advances in the Understanding of Mammalian Copper Transporters

(2012) Yanfang Wang et al.   Advances in Nutrition

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

(2011) N. A. Veldhuis et al.   BIOMETALS

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin and COMMD1 Independently Regulate Degradation of the Mammalian Copper ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin (Apolipoprotein J), a Molecular Chaperone That Facilitates Degradation of the Copper-ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biphasic effects of copper on neurotransmission in rat hippocampal neurons

(2011) Christian Peters et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

(2011) Wei Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Mapping Brain Metals to Evaluate Therapies for Neurodegenerative Disease

(2010) Bogdan Florin Gh Popescu et al.   CNS Neuroscience & Therapeutics

Role of Glutaredoxin1 and Glutathione in Regulating the Activity of the Copper-transporting P-type ATPases, ATP7A and ATP7B

(2010) William C. J. Singleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper Promotes the Trafficking of the Amyloid Precursor Protein

(2010) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper handling machinery of the brain

(2010) Svetlana Lutsenko et al.   Metallomics

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

An essential postsynaptic role for the ubiquitin proteasome system in slow homeostatic synaptic plasticity in cultured hippocampal neurons

(2010) S.K. Jakawich et al.   NEUROSCIENCE

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

(2009) Nicholas A. Veldhuis et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: Emerging roles

(2009) Sharon La Fontaine et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Copper-Triggered Aggregation of Ubiquitin

(2009) Fabio Arnesano et al.   PLoS One

Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms

(2008) Michael A. Cater et al.   BIOCHEMICAL JOURNAL

Glutathione and Parkinson's disease: Is this the elephant in the room?

(2008) Gail D. Zeevalk et al.   BIOMEDICINE & PHARMACOTHERAPY

ATP7B Copper-Regulated Traffic and Association With the Tight Junctions: Copper Excretion Into the Bile

(2008) Sonia Hernandez et al.   GASTROENTEROLOGY

Mitochondrial copper metabolism and delivery to cytochromec oxidase

(2008) Darryl Horn et al.   IUBMB LIFE

Longitudinal changes in zinc transport kinetics, metallothionein and zinc transporter expression in a blood–brain barrier model in response to a moderately excessive zinc environment

(2008) Dennis J. Bobilya et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY