The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies

Release of a disordered domain enhances HspB1 chaperone activity toward tau

(2020) Hannah E. R. Baughman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

(2020) Emily E. Selig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Aha1 co‐chaperone binding to human Hsp90

(2019) Javier Oroz et al.   PROTEIN SCIENCE

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

(2019) Li Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects

(2018) Leah K. Forsberg et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CacyBP/SIP, a Hsp90 binding chaperone, in cellular stress response

(2018) Agnieszka Góral et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

(2018) Toshiki Kijima et al.   Scientific Reports

Tau Protein Squired by Molecular Chaperones During Alzheimer’s Disease

(2018) Nalini Vijay Gorantla et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model

(2017) Javier Villadiego et al.   GLIA

A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

(2017) Sandrine C. Stiegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 activator Aha1 drives production of pathological tau aggregates

(2017) Lindsey B. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying Inhibitors of the Hsp90-Aha1 Protein Complex, a Potential Target to Drug Cystic Fibrosis, by Alpha Technology

(2017) Verena Ihrig et al.   SLAS Discovery

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy

(2016) Rick T. Dobrowsky   Current Diabetes Reports

Editorial (Thematic Issue: Heat Shock Proteins in Disease - From Molecular Mechanisms to Therapeutics)

(2016) Gabriela Chiosis   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism

(2016) B Wang et al.   MOLECULAR PSYCHIATRY

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1

(2016) Nikolai Hentze et al.   eLife

Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications

(2016) Daming Zuo et al.   Frontiers in Immunology

Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone

(2016) Agnieszka Góral et al.   PLoS One

Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons

(2015) Jiacheng Ma et al.   ACS Chemical Neuroscience

Inducible HSP70 Is Critical in Preventing the Aggregation and Enhancing the Processing of PMP22

(2015) Vinita G. Chittoor-Vinod et al.   ASN Neuro

Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice

(2015) Iolanda Lazaro et al.   DIABETES

Distal Symmetric Polyneuropathy

(2015) Brian C. Callaghan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Development of Noviomimetics as C-Terminal Hsp90 Inhibitors

(2015) Mercy Anyika et al.   ACS Medicinal Chemistry Letters

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

(2015) Thomas L. Prince et al.   PLoS One

Pharmacologic Interventions for Painful Diabetic Neuropathy

(2014) Marcio L. Griebeler et al.   ANNALS OF INTERNAL MEDICINE

Alternative approaches to Hsp90 modulation for the treatment of cancer

(2014) Jessica A Hall et al.   Future Medicinal Chemistry

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

Selective targeting of the stress chaperome as a therapeutic strategy

(2014) Tony Taldone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Biochemical Characterization of Protein Quality Control Mechanisms during Disease Progression in the C22 Mouse Model of CMT1A

(2013) Vinita G. Chittoor et al.   ASN Neuro

Heat Shock Prevents Insulin Resistance-Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling

(2013) P. A. Karpe et al.   DIABETES

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Induction of Heat Shock Protein 70 (Hsp70) prevents Neuregulin-Induced Demyelination by Enhancing the Proteasomal Clearance of c-Jun

(2012) Chengyuan Li et al.   ASN Neuro

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Synthesis and Evaluation of Novologues as C-Terminal Hsp90 Inhibitors with Cytoprotective Activity against Sensory Neuron Glucotoxicity

(2012) Bhaskar Reddy Kusuma et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-Terminal Heat Shock Protein 90 Inhibitor Decreases Hyperglycemia-induced Oxidative Stress and Improves Mitochondrial Bioenergetics in Sensory Neurons

(2012) Liang Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Diabetic neuropathy: clinical manifestations and current treatments

(2012) Brian C Callaghan et al.   LANCET NEUROLOGY

Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function

(2012) Urszula Wasik et al.   NEUROBIOLOGY OF AGING

Geldanamycin Derivative Ameliorates High Fat Diet-Induced Renal Failure in Diabetes

(2012) Hong-Mei Zhang et al.   PLoS One

αB-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion

(2011) Jeffrey B. Velotta et al.   ANNALS OF THORACIC SURGERY

Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

(2011) Jeffery D Eskew et al.   BMC CANCER

Small fibre neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy

(2011) R. A. Malik et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management

(2011) S. Tesfaye et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Functional rescue of experimental ischemic optic neuropathy with αB-crystallin

(2011) S Pangratz-Fuehrer et al.   EYE

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

(2011) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Screen for Enhancers of Clearance Identifies Huntingtin as a Heat Shock Protein 90 (Hsp90) Client Protein

(2011) Barbara Baldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

(2011) Daniel W. Neef et al.   NATURE REVIEWS DRUG DISCOVERY

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

(2011) Liliana Batista-Nascimento et al.   PLoS One

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

(2011) Ahmet Arac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting Heat-Shock Protein 90 Reverses Sensory Hypoalgesia in Diabetic Mice

(2010) Michael J Urban et al.   ASN Neuro

Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells

(2010) Andrija Finka et al.   CELL STRESS & CHAPERONES

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

(2010) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

HSP27: Mechanisms of Cellular Protection Against Neuronal Injury

(2009) R. Stetler et al.   CURRENT MOLECULAR MEDICINE

Heat Shock Proteins in Diabetes and Wound Healing

(2009) Mustafa Atalay et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

To fold or not to fold: modulation and consequences of Hsp90 inhibition

(2009) Laura B Peterson et al.   Future Medicinal Chemistry

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

(2009) John Koren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperlipidemia: a new therapeutic target for diabetic neuropathy

(2009) Andrea M. Vincent et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line

(2008) Yuanming Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Inflammation, heat shock proteins, and type 2 diabetes

(2008) Philip L. Hooper et al.   CELL STRESS & CHAPERONES

Diabetic polyneuropathy: an update

(2008) Douglas W Zochodne   CURRENT OPINION IN NEUROLOGY

Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia

(2008) Fei Sun et al.   FASEB JOURNAL

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Pharmacological induction of the heat shock response improves myelination in a neuropathic model

(2008) Sunitha Rangaraju et al.   NEUROBIOLOGY OF DISEASE

Diabetic neuropathy: Mechanisms to management

(2008) James L. Edwards et al.   PHARMACOLOGY & THERAPEUTICS

Small heat shock proteins Hsp27 or αB-crystallin and the protein components of neurofibrillary tangles: Tau and neurofilaments

(2007) Cecilia Björkdahl et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

(2007) Kyeong Lee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY