Review
Oncology
Tomasz Sliwinski, Tomasz Kowalczyk, Przemyslaw Sitarek, Marta Kolanowska
Summary: This paper reviews the most recent literature on orchid-derived bioactive substances with anticancer properties, highlighting the potential antitumor chemicals found in many species of orchids. However, the research on the chemical composition and anticancer properties of orchids is still limited, with most studies focusing on Asian taxa. Further research on American and African species, as well as accurate sample identification, is necessary to fully assess the anticancer potential of orchids.
Article
Pharmacology & Pharmacy
Zuzanna Rzepka, Ewa Bebenek, Elwira Chrobak, Dorota Wrzesniok
Summary: The synthesized new 28-indole-betulin derivatives showed promising anticancer activity, particularly against MCF-7 breast cancer cells, possibly through inducing apoptosis.
Article
Biochemistry & Molecular Biology
Irina Tolmacheva, Yulia Beloglazova, Mikhail Nazarov, Olga Gagarskikh, Victoria Grishko
Summary: Multidrug resistance (MDR) is a common occurrence in cancer treatment, where cancer cells become resistant to chemotherapy drugs due to overexpression of ATP-binding cassette efflux transporters, including P-glycoprotein (P-gp). A new semi-synthetic derivative, MK, was found to have the highest cytotoxicity against cancer cells, but it was not identified as a P-gp inhibitor or substrate. Further studies suggest that the cytotoxic effect of MK on cancer cells may be induced through the ROS-mediated mitochondrial pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tian Li, An-Di Zhou, Li-Fei Bai, Xiao-Yang Zhang, Yu-Ting Zhou, Hai-Li Yang, Le-Tian Xu, Xin-Qin Guo, Xi-Yu Zhu, Dong-Jin Wang, Hong-Wei Gu, Xiao-Ming Wang
Summary: This study investigated the biological activities of three novel palbociclib derivatives (HP-1, HP-2, and HP-3), designed and synthesized from Palbociclib and 10-HCPT. The results showed that these derivatives had anti-cancer effects by acting on dual targets, with high efficiencies and low toxicities, providing a new direction for the study of palbociclib derivatives.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jayanta Dowarah, Devanshi Patel, Brilliant N. Marak, Umesh Chand Singh Yadav, Pramod Kumar Shah, Pradeep Kumar Shukla, Ved Prakash Singh
Summary: For the first time, Citrus macroptera juice was utilized to synthesize dihydropyrimidine (DHPM) derivatives via the Biginelli reaction, showing potential anticancer activity, especially against lung adenocarcinoma, in both in vitro and in vivo studies. The compounds with a chloro-group at the 3- or 4-position in the substituted ring of DHPM exhibited higher binding affinity for the human kinesin Eg5 enzyme and induced significant cell death in human A549 lung adenocarcinoma cells. This suggests that a deactivating group (chlorine) at the 3- or 4-position in the substituted ring of DHPM may be a promising anticancer drug candidate for treating various types of cancers, particularly lung cancer.
Article
Chemistry, Organic
Russell R. A. Kitson, Christopher J. Moody
Summary: This paper reports the synthesis of a series of 19-substituted geldanamycin derivatives using optimized synthetic methods. These new compounds are of significant medicinal interest due to their significantly reduced toxicity compared to the unsubstituted counterparts previously evaluated in clinical trials.
Article
Chemistry, Multidisciplinary
Meng Yin, Yongsheng Fang, Xiaotong Sun, Minggao Xue, Caimei Zhang, Zhiyun Zhu, Yamiao Meng, Lingmei Kong, Yi Yi Myint, Yan Li, Jingfeng Zhao, Xiaodong Yang
Summary: Three series of podophyllotoxin derivatives were synthesized with various nitrogen-containing heterocycles. The antitumor activity of these derivatives was evaluated against human tumor cell lines in vitro. The results showed that podophyllotoxin-imidazolium salts and podophyllotoxin-1,2,4-triazolium salts a1-a20 exhibited excellent cytotoxic activity, with a6 being the most potent compound. Podophyllotoxin-1,2,3-triazole derivatives b1-b5 showed medium cytotoxic activity, while podophyllotoxin-amine compounds c1-c3 displayed good cytotoxic activity. Further experiments revealed that compound a6 induced G2/M cell cycle arrest and apoptosis in HCT-116 cells.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ewa Bebenek, Elwira Chrobak, Zuzanna Rzepka, Dorota Wrzesniok
Summary: In the search for potential medicinal substances for oncology, new compounds combining the betulin molecule and the indole system were synthesized. The structure of the obtained derivatives was confirmed and their anticancer activity was evaluated. The results indicated that one derivative showed promising cytotoxic effect on breast cancer cells, making it a potential starting point for further research in breast cancer therapy or synthesis of new derivatives.
Article
Biochemistry & Molecular Biology
Yong-Feng Guan, Xiu-Juan Liu, Xin-Ying Yuan, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Jian Song, Wen Li, Sai-Yang Zhang
Summary: In this study, quinoline-chalcone derivatives were designed and synthesized by linking chalcone fragment to the quinoline scaffold, resulting in compound 12e showing promising inhibitory activity against multiple cancer cell lines. Mechanism studies indicated that compound 12e may exert its anticancer effects through various pathways.
Review
Chemistry, Medicinal
Cesar Emiliano Hoffmann da Silva, Grace Gosmann, Saulo Fernandes de Andrade
Summary: This review summarizes the synthetic methods and strategies for obtaining anticancer derivatives of limonene and perillyl alcohol from 2000 to 2020, discusses the structure-activity relationships of the most active derivatives, and illustrates potential anticancer compounds.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Arsenio Rodrigues Oliveira, Flaviana Alves dos Santos, Larissa Pelagia de Lima Ferreira, Maira Galdino da Rocha Pitta, Marcius Vinicius de Oliveira Silva, Marcos Verissimo de Oliveira Cardoso, Aline Ferreira Pinto, Pascal Marchand, Moacyr Jesus Barreto de Melo Rego, Ana Cristina Lima Leite
Summary: The study identified that the phthalimidobis-1,3-thiazoles sub-series compounds exhibited good anti-tumor activity in tumor cell lines, with viability values below 59%. The importance of the 1,3-thiazole ring in enhancing anti-tumor activity was highlighted.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Yufang Cao, Simeng Xu, Cangcang Xu, Di Xiao, Zhuliang Chen, Wei Wang, Zhiren Wang, Xiaoping Yang
Summary: This study synthesized phenformin derivatives with different substituents and screened their antiproliferative activities. It was found that the introduction of -Cl and -OCF3 substituents significantly increased the antiproliferative activity of phenformin.
Article
Chemistry, Physical
Naganjaneyulu Gariganti, Shiva Krishna Loke, Eswar Pagadala, Poojitha Chinta, Bhaskar Poola, Prabhakar Chetti, Arubhi Bansal, Balajee Ramachandran, V. Srinivasadesikan, Ravi K. Kottalanka
Summary: A series of amide derivatives derived from 1,2,3-triazole-benzofuran hybrids were synthesized and their anticancer activities were evaluated. The compounds exhibited good to moderate activity against human cancer cell lines. Molecular docking simulations and experimental findings were consistent, indicating the inhibitory actions of the amide derivatives. These findings suggest that the amide derivatives could be potential alternative anticancer agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Til Bahadur Thapa Magar, Jusuk Lee, Ji Hoon Lee, Juhee Jeon, Pallavi Gurung, Junmo Lim, Yong-Wan Kim
Summary: A novel series of chlorin e6-curcumin derivatives were synthesized and tested for their photodynamic treatment (PDT) efficacy against human pancreatic cancer cell lines. Compound 17 showed excellent cellular internalization capability and higher phototoxicity compared to the parent compound Ce6. In pancreatic cell lines, 17 induced apoptosis in a dose-dependent manner and activated intrinsic apoptosis, resulting in cancer cell death. Structure-activity relationship studies revealed that the incorporation of additional methyl ester moiety and conjugation to the enone moiety of curcumin enhanced cellular uptake and PDT efficacy. In vivo PDT testing in melanoma mouse models demonstrated that 17-PDT greatly reduced tumor growth, indicating its potential as an effective photosensitizer for PDT anticancer therapy.
Article
Biochemistry & Molecular Biology
Anita Raducka, Marcin Swiatkowski, Izabela Korona-Glowniak, Barbara Kapron, Tomasz Plech, Malgorzata Szczesio, Katarzyna Gobis, Malgorzata Iwona Szynkowska-Jozwik, Agnieszka Czylkowska
Summary: In this study, a series of coordination compounds containing zinc and benzimidazole derivatives were synthesized and characterized using various analytical and spectroscopic techniques. The results indicated that these new compounds showed improved anticancer properties, as well as antibacterial and antifungal activities, demonstrating potential as antitumor agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Anoop Singh, Narinder Singh, Navneet Kaur, Doo Ok Jang
Summary: A novel biomass-derived heterogeneous catalyst has been developed for the selective reduction of nitro compounds, which is effective in various environmentally friendly applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Amanpreet Singh, Gagandeep Singh, Shilpa Sharma, Navneet Kaur, Narinder Singh
Summary: In this study, a metal-free and green catalyst based on sulfonic acid functionalized carbon quantum dots (CQDs) derived from biomass was designed and developed for one pot multicomponent reactions. The catalyst exhibited excellent reusability and catalytic activity for the synthesis of biologically important heterocycles in pure aqueous medium.
Article
Chemistry, Applied
Anoop Singh, Narinder Singh, Navneet Kaur
Summary: In this study, fluorescent conjugated and nonconjugated polythioamide were synthesized using a one-pot method with dialdehyde, diamines, and elemental sulfur, in the presence of IL1-IL2@Fe(3)O(4)NPs as a catalyst via the Willgerodt-Kindler reaction. A magnetized iron nanoparticles heterogeneous catalyst coated with an ionic liquid was synthesized. The catalyst was characterized by BET, XPS, PXRD, TEM, and FTIR spectroscopy. The multicomponent reaction proceeded smoothly at ambient temperature with excellent yield in the presence of the catalyst. The magnetic catalyst could be easily recovered, indicating the potential of this method for efficient polymerization of structurally diversified polythioamides.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Plant Sciences
Gwi Ja Hwang, Mina Jang, Sangkeun Son, Gil Soo Kim, Byeongsan Lee, Kyung Taek Heo, Geum Jin Kim, Hyukjae Choi, Jae-Seoun Hur, Jun-Pil Jang, Sung-Kyun Ko, Young-Soo Hong, Jong Seog Ahn, Jae-Hyuk Jang
Summary: In this study, a new secondary metabolite, ulleungdolin, was isolated from the co-culture of an actinomycete and a fungus. Ulleundolin exhibited antimigration effect on breast cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Analytical
Geetika Bhardwaj, Randeep Kaur, Navneet Kaur, Narinder Singh
Summary: A new receptor R1 was synthesized and prepared as nanoparticles to detect azidothymidine. The nanoparticle probe showed better sensing performance for azidothymidine in various techniques such as cyclic voltammetry.
Article
Chemistry, Multidisciplinary
Randeep Kaur, Geetika Bhardwaj, Narinder Singh, Navneet Kaur
Summary: A simplistic, versatile, and general approach to constructing functionalized electrochemical materials is described in this study. This approach involves modifying multiwalled carbon nanotubes (MWCNT) with dipodal naphthyl-based dipodal urea (KR-1) through non-covalent functionalization, complexing the modified MWCNT with Hg2+ to enhance electron transfer and detection response, and applying the functionalized electrochemical material (Hg/KR-1@MWCNT) for real-time electrochemical monitoring of harmful antiviral drug (IUdR) levels in human serum.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Green & Sustainable Science & Technology
Harpreet Kaur, Divya, Navneet Kaur, Narinder Singh
Summary: Exposure to CO2 has harmful effects on human health and the environment. In this study, we developed an electrochemical method using calix [4]Arene-based nanohybrids for the detection of dissolved CO2 and its conversion into formic acid. This sustainable method has high efficiency and practical utility.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Chemistry, Multidisciplinary
Anoop Singh, Narinder Singh, Navneet Kaur, Doo Ok Jang
Summary: A chitosan-poly(vinyl alcohol)-ionic liquid-grafted hydrogel was prepared and characterized for water purification. The swelling properties of the hydrogel were optimized, and it showed a maximum swelling of 330%. The hydrogel exhibited high removal rates for dye, nitrite, and Pb2+, and could effectively recover oil from an oil-water mixture due to electrostatic interactions.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Amanpreet Singh, Gagandeep Singh, Navneet Kaur, Narinder Singh
Summary: A DNA/Carbon Quantum Dot (CQD) based hybrid nanoarchitecture system was developed for the selective detection of Ochratoxin A (OTA). The system showed modulation in the emission spectrum after interaction with OTA, with a binding constant of 3.5 x 10(5) M-1, a limit of detection of 14 nM, limit of quantification of 47 nM, and working range of 1-10 mu M. The binding mode of the CQD@DNA hybrid nanoarchitecture assembly with OTA was confirmed using fluorescence, UV-visible absorption spectroscopy, and FTIR techniques. The system was also demonstrated to effectively quantify OTA in real food monitoring analysis, making it a potential candidate for convenient food safety and quality monitoring for human health.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Physical
Geetika Bhardwaj, Randeep Kaur, Sanjeev Saini, Navneet Kaur, Narinder Singh
Summary: This study presents a method for detecting insulin using a 4H-chromene derivative surface decorated with AgNPs. The method exhibits a low detection limit, high sensitivity, and excellent reproducibility, and can accurately detect insulin in both liquid and solid state. This cost-effective and environment friendly method has significant implications in the field of diabetes management.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
Amanpreet Singh, Monika Chaudhary, Meenakshi Verma, Navneet Kaur, Narinder Singh
Summary: Anion-induced self-assembly is a growing research field that provides a better understanding of natural self-assemblies such as DNA, proteins, peptides, etc. In this study, nanohybrids of glutathione tripeptide and naphthalimide based compounds were fabricated and their self-assembly behavior was explored. The nanohybrids showed enhanced fluorescence intensity with bisulphate anions, indicating potential applications in bisulphate recognition. The morphology of the nanohybrids was studied using HRTEM and STEM.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Geetika Bhardwaj, Randeep Kaur, Sanjeev Saini, Navneet Kaur, Narinder Singh
Summary: A sensor based on Ni@G1 core-shell nanoparticles has been developed, which exhibits high selectivity and sensitivity for BrdU detection. The sensor can detect BrdU with a detection limit of 9 nM in an aqueous medium, and shows no significant interference from pH, salt, and temperature.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Manish Kumar, Navneet Kaur, Narinder Singh
Summary: This study reports the development of CuNi alloy nanoparticle-decorated MWCNTs stabilized by an ionic liquid for the sensitive detection and detoxification of imidacloprid. The material exhibited excellent electrocatalytic activity and selectivity towards imidacloprid, as well as high recovery rates in spiked corn and rice samples. Moreover, it achieved almost complete degradation of imidacloprid in aqueous systems with good reusability.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Chemistry, Multidisciplinary
Anoop Singh, Sanjeev Saini, Narinder Singh, Navneet Kaur, Doo Ok Jang
Summary: Cellulose was extracted from rice straw and a highly active solid-supported catalytic model was developed in this study. By conjugating with poly(ethylene-co-vinyl acetate) (PEVA) and inserting silver nanoparticles, a composite catalyst was successfully fabricated. The hybrid catalyst exhibited excellent reaction yields in the Willgerodt-Kindler reaction and showed high stability and recyclability.
Article
Polymer Science
Manpreet Kaur, Mayank, Deepak Bains, Gagandeep Singh, Navneet Kaur, Narinder Singh
Summary: Efficient multicomponent tandem polymerization (MCTP) has recently become a focus of interest. Synthesis of fluorescent non-conjugated polyamide gels using a newly developed magnetic catalyst under solvent free conditions resulted in high yields of high molecular weight products. Characterization through various techniques confirmed the structure of the prepared polyamide gels, showing great potential for this simple and efficient polymerization approach.
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
