Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications

Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges

(2016) Amit Saxena et al.   Translational Research

Heat Shock Protein A4 Controls Cell Migration and Gastric Ulcer Healing

(2015) Toshiharu Sakurai et al.   DIGESTIVE DISEASES AND SCIENCES

Involvement of Heat Shock Protein A4/Apg-2 in Refractory Inflammatory Bowel Disease

(2015) Teppei Adachi et al.   INFLAMMATORY BOWEL DISEASES

HSP105 Recruits Protein Phosphatase 2A To Dephosphorylate β-Catenin

(2015) Nancy Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular chaperones and neuronal proteostasis

(2015) Heather L. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development

(2015) Sergei Y. Sokol   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics

(2015) Hongxia Wang et al.   Frontiers in Oncology

Gene expression of Hsps in normal and abnormal embryonic development of mouse hindlimbs

(2014) Zhengli Yan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury

(2014) Binnur Eroglu et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Function by Hypoxia-Upregulated Protein 1

(2014) L. Giffin et al.   JOURNAL OF VIROLOGY

Protective mucosal immunity mediated by epithelial CD1d and IL-10

(2014) Torsten Olszak et al.   NATURE

The inflammatory response in myocardial injury, repair and remodelling

(2014) Nikolaos G. Frangogiannis   Nature Reviews Cardiology

A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity

(2013) X. Yu et al.   CANCER RESEARCH

The ins-and-outs of endosomal antigens for cross-presentation

(2013) Verena Schuette et al.   CURRENT OPINION IN IMMUNOLOGY

High molecular weight stress proteins: Identification, cloning and utilisation in cancer immunotherapy

(2013) Xiang-Yang Wang et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Enhanced Endoplasmic Reticulum Entry of Tumor Antigen Is Crucial for Cross-Presentation Induced by Dendritic Cell-Targeted Vaccination

(2013) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Cancer risk in immune-mediated inflammatory diseases (IMID)

(2013) Rudi Beyaert et al.   Molecular Cancer

Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

(2013) Daniela Hartl et al.   PLoS One

Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm

(2013) Y. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice

(2012) Ken-Ichiro Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis

(2012) Sathi Babu Chodisetti et al.   BMC IMMUNOLOGY

Enhanced anti-tumor effects of HPV16E749–57-based vaccine by combined immunization with poly(I:C) and oxygen-regulated protein 150

(2012) Shisheng Chen et al.   Cancer Epidemiology

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Endoplasmic reticulum chaperone glucose regulated protein 170–Pokemon complexes elicit a robust antitumor immune response in vivo

(2012) Bangqing Yuan et al.   IMMUNOBIOLOGY

Human Heat Shock Protein 105/110 kDa (Hsp105/110) Regulates Biogenesis and Quality Control of Misfolded Cystic Fibrosis Transmembrane Conductance Regulator at Multiple Levels

(2012) Anita Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2012) Maria Mansilla et al.   MOLECULAR MEDICINE

Gene expression of Hsp70, Hsp90 and Hsp110 families in normal palate and cleft palate during mouse embryogenesis

(2012) Yongfei Zhu et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells

(2011) Nobuyuki Yamagishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target

(2011) R. Zappasodi et al.   BLOOD

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

(2011) Y Wang et al.   BRITISH JOURNAL OF CANCER

Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells

(2011) Ignacio Cebrian et al.   CELL

Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell

(2011) Nancy Dekki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells

(2011) Fanlei Hu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity

(2011) Daming Zuo et al.   FASEB JOURNAL

Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation

(2011) Katie C. Crawford et al.   GENESIS

Involvement of Oxygen-regulated Protein 150 in AMP-activated Protein Kinase-mediated Alleviation of Lipid-induced Endoplasmic Reticulum Stress

(2011) Yun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD204 Suppresses Large Heat Shock Protein-Facilitated Priming of Tumor Antigen gp100-Specific T Cells and Chaperone Vaccine Activity against Mouse Melanoma

(2011) J. Qian et al.   JOURNAL OF IMMUNOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Effects of ORP150 on appearance and function of pancreatic beta cells following acute necrotizing pancreatitis

(2011) Wen-Hong Deng et al.   PATHOLOGY RESEARCH AND PRACTICE

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis

(2010) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Hsp110-Mediated Enhancement of CD4+T Cell Responses to the Envelope Glycoprotein of Members of the FamilyFlaviviridae In VitroDoes Not OccurIn Vivo

(2010) Kerry McLaughlin et al.   Clinical and Vaccine Immunology

Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo

(2010) Hilal Arnouk et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

The Endoplasmic Reticulum Grp170 Acts as a Nucleotide Exchange Factor of Hsp70 via a Mechanism Similar to That of the Cytosolic Hsp110

(2010) Claes Andréasson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 90 Mediates Efficient Antigen Cross Presentation through the Scavenger Receptor Expressed by Endothelial Cells-I

(2010) A. Murshid et al.   JOURNAL OF IMMUNOLOGY

Superior Antitumor Response Induced by Large Stress Protein Chaperoned Protein Antigen Compared with Peptide Antigen

(2010) X. Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Loss of Hsp110 Leads to Age-Dependent Tau Hyperphosphorylation and Early Accumulation of Insoluble Amyloid  

(2010) B. Eroglu et al.   MOLECULAR AND CELLULAR BIOLOGY

Vaccination with a chaperone complex based on PSCA and GRP170 adjuvant enhances the CTL response and inhibits the tumor growth in mice

(2010) Wenqian Huo et al.   VACCINE

Heat-shock proteins can promote as well as regulate autoimmunity

(2009) Rajesh Rajaiah et al.   AUTOIMMUNITY REVIEWS

Secretion of stress protein grp170 promotes immune-mediated inhibition of murine prostate tumor

(2009) Ping Gao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Innate immune receptors on neutrophils and their role in chronic lung disease

(2009) B. Koller et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Nucleotide Binding by Lhs1p Is Essential for Its Nucleotide Exchange Activity and for Functionin Vivo

(2009) Jeanine de Keyzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting to Static Endosome Is Required for Efficient Cross-Presentation of Endoplasmic Reticulum-Resident Oxygen-Regulated Protein 150-Peptide Complexes

(2009) G. Kutomi et al.   JOURNAL OF IMMUNOLOGY

T Cell Activation by Heat Shock Protein 70 Vaccine Requires TLR Signaling and Scavenger Receptor Expressed by Endothelial Cells-1

(2009) J. Gong et al.   JOURNAL OF IMMUNOLOGY

Heat shock proteins on the human sperm surface

(2009) Soren Naaby-Hansen et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation

(2009) Jin-Xiang Yuan et al.   Reproductive Biology and Endocrinology

Chlamydia trachomatis Infection and Anti-Hsp60 Immunity: The Two Sides of the Coin

(2009) Francesco Cappello et al.   PLoS Pathogens

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin

(2008) B. Liu et al.   BLOOD

Secretable Chaperone Grp170 Enhances Therapeutic Activity of a Novel Tumor Suppressor, mda-7/IL-24

(2008) P. Gao et al.   CANCER RESEARCH

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells

(2008) M Sanson et al.   CELL DEATH AND DIFFERENTIATION

Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation

(2008) Ayesha Murshid et al.   Expert Review of Vaccines

Nuclear Localization Mechanism of Hsp105  and its Possible Function in Mammalian Cells

(2008) Y. Saito et al.   JOURNAL OF BIOCHEMISTRY

Heat shock proteins: essential proteins for apoptosis regulation

(2008) D. Lanneau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

(2008) Sven Burgdorf et al.   NATURE IMMUNOLOGY

Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity

(2008) C. Andreasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress

(2007) David D. Arrington et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY