IL‐1/IL‐1R signaling induced by all‐ trans ‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium

Complement factor H in AMD: Bridging genetic associations and pathobiology

(2018) Christopher B. Toomey et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome

(2018) Riccardo Natoli et al.   Frontiers in Immunology

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

(2018) Isha Akhtar‐Schäfer et al.   EMBO Molecular Medicine

Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina

(2018) Zhan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease

(2017) Tamara L. Lenis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness

(2017) Avery E. Sears et al.   Translational Vision Science & Technology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation

(2016) Lei Wang et al.   JOURNAL OF PATHOLOGY

Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage

(2015) Carolina Brandstetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of age-related macular degeneration-like pathology by complement factor H

(2015) Christopher B. Toomey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Involvement of Endoplasmic Reticulum Stress in All-Trans-Retinal-Induced Retinal Pigment Epithelium Degeneration

(2014) Jie Li et al.   TOXICOLOGICAL SCIENCES

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

(2013) Chang Luo et al.   EXPERIMENTAL EYE RESEARCH

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal

(2013) Hideo Kohno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Complement Pathway Deficiency Ameliorates Chronic Smoke-Induced Functional and Morphological Ocular Injury

(2013) Alex Woodell et al.   PLoS One

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

Systemic Human CR2-Targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-Induced Choroidal Neovascularization

(2012) Bärbel Rohrer et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration

(2012) Katayoon B Ebrahimi et al.   JOURNAL OF PATHOLOGY

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer

(2012) Faraz Quazi et al.   Nature Communications

Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration

(2011) Roxana A. Radu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sublytic Membrane-Attack-Complex (MAC) Activation Alters Regulated Rather than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal Pigment Epithelium Monolayers

(2011) Kannan Kunchithapautham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization

(2011) Bärbel Rohrer et al.   MOLECULAR IMMUNOLOGY

Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice

(2009) Akiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid meets all-trans-retinal: the making of RPE bisretinoids

(2009) Janet R. Sparrow et al.   JOURNAL OF LIPID RESEARCH

Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina

(2008) Mei Chen et al.   EXPERIMENTAL EYE RESEARCH

Retinopathy in Mice Induced by Disrupted All-trans-retinal Clearance

(2008) Akiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY