Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation

(2015) Ádám I. Csincsi et al.   JOURNAL OF IMMUNOLOGY

p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium

(2014) Lei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

(2014) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells

(2014) Marisol Cano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation

(2014) Kannan Kunchithapautham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

(2014) L. Deban et al.   JOURNAL OF IMMUNOLOGY

Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis

(2014) Franca Orsini et al.   Frontiers in Cellular Neuroscience

Relationship between Systemic Cytokines and Complement Factor H Y402H Polymorphism in Patients With Dry Age-Related Macular Degeneration

(2013) Sijia Cao et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3

(2013) Guidong Yao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Interaction of Complement Factor H and Fibulin3 in Age-Related Macular Degeneration

(2013) M. Keith Wyatt et al.   PLoS One

PTX3 as a paradigm for the interaction of pentraxins with the Complement system

(2013) Antonio Inforzato et al.   SEMINARS IN IMMUNOLOGY

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Complement C3: an emerging risk factor in cardiometabolic disease

(2012) E. Hertle et al.   DIABETOLOGIA

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

(2012) Akshaya K. Meher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caspase-1 Has Both Proinflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1  and IL-18

(2012) I. Hitzler et al.   JOURNAL OF IMMUNOLOGY

Atypical Hemolytic Uremic Syndrome-Associated Variants and Autoantibodies Impair Binding of Factor H and Factor H-Related Protein 1 to Pentraxin 3

(2012) A. Kopp et al.   JOURNAL OF IMMUNOLOGY

Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration

(2012) Katayoon B Ebrahimi et al.   JOURNAL OF PATHOLOGY

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Complement C3 and cleavage products in cardiometabolic risk

(2011) Altan Onat et al.   CLINICA CHIMICA ACTA

M-Ficolin Interacts with the Long Pentraxin PTX3: A Novel Case of Cross-Talk between Soluble Pattern-Recognition Molecules

(2011) E. Gout et al.   JOURNAL OF IMMUNOLOGY

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Increases of pentraxin 3 plasma levels in patients with Parkinson's disease

(2011) Ho-Won Lee et al.   MOVEMENT DISORDERS

Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein

(2011) Anne Braunschweig et al.   PLoS One

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

(2010) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate, Including That in Bruch's Membrane, Inhibits the Complement Alternative Pathway: Implications for Age-Related Macular Degeneration

(2010) U. Kelly et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration

(2009) S. Cherepanoff et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition

(2009) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of PTX3 Disulfide Bond Network and Its Multimeric Status in Cumulus Matrix Organization

(2008) Antonio Inforzato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells

(2008) Yuko Yamada et al.   JOURNAL OF NEUROCHEMISTRY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE