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Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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Complement Component C1q Mediates Mitochondria-Driven Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury

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Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

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A role for mitochondria in NLRP3 inflammasome activation

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

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(2009) Troels Vinding   ACTA OPHTHALMOLOGICA

Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration

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Autophagy, exosomes and drusen formation in age-related macular degeneration

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Microglia in the Mouse Retina Alter the Structure and Function of Retinal Pigmented Epithelial Cells: A Potential Cellular Interaction Relevant to AMD

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

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(2008) Ruslan Medzhitov   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Oxidative damage–induced inflammation initiates age-related macular degeneration

(2008) Joe G Hollyfield et al.   NATURE MEDICINE

Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

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