Functions of Wnt and Hedgehog-containing extracellular vesicles in development and disease

Polarized sorting of Patched enables cytoneme‐mediated Hedgehog reception in the Drosophila wing disc

(2020) Laura González‐Méndez et al.   EMBO JOURNAL

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

(2020) Ian J. McGough et al.   NATURE

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

(2019) Parysatis Sachs et al.   Nature Communications

WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts

(2019) Edyta Działo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors

(2019) Zsuzsanna Szvicsek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila

(2019) Jong-Hoon Won et al.   Cell Death & Disease

FZD10 Carried by Exosomes Sustains Cancer Cell Proliferation

(2019) Scavo et al.   Cells

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

(2019) Dongsic Choi et al.   ACS Nano

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing

(2019) Varun Chaudhary et al.   DEVELOPMENT

Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging

(2019) Giulia Corso et al.   Journal of Extracellular Vesicles

Improved Label-Free Identification of Individual Exosome-like Vesicles with Au@Ag Nanoparticles as SERS Substrate

(2019) Juan C. Fraire et al.   ACS Applied Materials & Interfaces

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes

(2019) Shusuke Yokota et al.   PLoS One

Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

(2019) Hina Kalra et al.   Journal of Extracellular Vesicles

ESCRTs in membrane sealing

(2018) Maja Radulovic et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

ESCRT-dependent control of membrane remodelling during cell division

(2018) Caroline Louise Stoten et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

(2018) Amrita Datta et al.   Scientific Reports

Microparticles harbouring Sonic hedgehog morphogen improve the vasculogenesis capacity of endothelial progenitor cells derived from myocardial infarction patients

(2018) Carlos Bueno-Betí et al.   CARDIOVASCULAR RESEARCH

Upstream Hedgehog signaling components are exported in exosomes of cervical cancer cell lines

(2018) Aman Sharma et al.   Nanomedicine

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes

(2018) Sang H. Lee et al.   Nature Communications

The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles

(2018) Michael E. Coulter et al.   Cell Reports

Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

(2018) Ariel M Pani et al.   eLife

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

(2017) Zachary J. DeBruine et al.   GENES & DEVELOPMENT

Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

(2017) Zhe Huang et al.   ONCOLOGY RESEARCH

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cytoneme-mediated cell-cell contacts for Hedgehog reception

(2017) Laura González-Méndez et al.   eLife

Endothelial microparticles carrying hedgehog-interacting protein induce continuous endothelial damage in the pathogenesis of acute graft-versus-host disease

(2016) Di-min Nie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

Novel ESCRT functions in cell biology: spiraling out of control?

(2016) Coen Campsteijn et al.   CURRENT OPINION IN CELL BIOLOGY

Hedgehog signalling

(2016) Raymond Teck Ho Lee et al.   DEVELOPMENT

Exosomes in developmental signalling

(2016) Ian John McGough et al.   DEVELOPMENT

Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth

(2016) Leen Bussche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs

(2016) Yasuo Yamazaki et al.   NATURE CELL BIOLOGY

Hair stem cells born without a home

(2016) Paulina Strzyz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Making, Exporting, and Modulating Wnts

(2016) Paul F. Langton et al.   TRENDS IN CELL BIOLOGY

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

(2016) Subhrajit Saha et al.   Nature Communications

Probing extracellular Sonic hedgehog in neurons

(2016) Erez Eitan et al.   Biology Open

Different populations of Wnt-containing vesicles are individually released from polarized epithelial cells

(2016) Qiuhong Chen et al.   Scientific Reports

Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk

(2015) Melania Dovizio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bending Gradients: How the Intestinal Stem Cell Gets Its Home

(2015) Amy E. Shyer et al.   CELL

Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis

(2015) Juan Wang et al.   CURRENT BIOLOGY

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling

(2015) Gisela D’Angelo et al.   DEVELOPMENTAL CELL

Myristoylated CIL-7 regulates ciliary extracellular vesicle biogenesis

(2015) Julie E. Maguire et al.   MOLECULAR BIOLOGY OF THE CELL

Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion

(2015) Anup Parchure et al.   MOLECULAR BIOLOGY OF THE CELL

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing

(2015) Bin Zhang et al.   STEM CELLS

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Identification of a Family of Fatty-Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties

(2015) Jun Long et al.   Cell Reports

Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/β-Catenin Pathway

(2015) Bin Zhang et al.   Stem Cells Translational Medicine

Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

(2015) Youngshik Choe et al.   eLife

Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma

(2014) R. Koch et al.   BLOOD

Glial Wingless/Wnt Regulates Glutamate Receptor Clustering and Synaptic Physiology at the Drosophila Neuromuscular Junction

(2014) K. S. Kerr et al.   JOURNAL OF NEUROSCIENCE

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Sonic hedgehog signaling in the postnatal brain

(2014) Arturo Álvarez-Buylla et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

(2014) Neha Vyas et al.   Scientific Reports

The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms

(2013) H. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sonic Hedgehog Carried by Microparticles Corrects Angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice

(2013) Vannina González Marrachelli et al.   PLoS One

Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals

(2013) Wilhelm Palm et al.   PLOS BIOLOGY

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

(2012) A. Creanga et al.   GENES & DEVELOPMENT

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

(2012) Kate Koles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

Wnt/Wingless Signaling in Drosophila

(2012) S. Swarup et al.   Cold Spring Harbor Perspectives in Biology

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

Cytoneme-Mediated Delivery of Hedgehog Regulates the Expression of Bone Morphogenetic Proteins to Maintain Germline Stem Cells in Drosophila

(2012) Patricia Rojas-Ríos et al.   PLOS BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Host factors involved in retroviral budding and release

(2011) Juan Martin-Serrano et al.   NATURE REVIEWS MICROBIOLOGY

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium

(2011) A. Callejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

(2011) K. A. Mulligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Podocyte membrane vesicles in urine originate from tip vesiculation of podocyte microvilli

(2010) Masanori Hara et al.   HUMAN PATHOLOGY

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Microparticles Carrying Sonic Hedgehog Favor Neovascularization through the Activation of Nitric Oxide Pathway in Mice

(2010) Tarek Benameur et al.   PLoS One

Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors

(2009) R. Soleti et al.   CARCINOGENESIS

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

The enterocyte microvillus is a vesicle-generating organelle

(2009) Russell E. McConnell et al.   JOURNAL OF CELL BIOLOGY

Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia

(2009) A Valencia et al.   LEUKEMIA

Shaping Morphogen Gradients by Proteoglycans

(2009) D. Yan et al.   Cold Spring Harbor Perspectives in Biology

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

(2008) Neha Vyas et al.   CELL

Trafficking and function of the tetraspanin CD63

(2008) Maaike S. Pols et al.   EXPERIMENTAL CELL RESEARCH

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

(2008) Rafal P. Witek et al.   GASTROENTEROLOGY

Matrix vesicles originate from apical membrane microvilli of mineralizing osteoblast-like Saos-2 cells

(2008) Cyril Thouverey et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE