Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

(2017) Aaron H. Nile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1

(2017) Kyoko Matoba et al.   Cell Reports

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay

(2016) Melissa V. Gammons et al.   JOURNAL OF CELL SCIENCE

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled

(2016) Melissa V. Gammons et al.   MOLECULAR CELL

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Wnt pathway activation by ADP-ribosylation

(2016) Eungi Yang et al.   Nature Communications

Structural basis of the Norrin-Frizzled 4 interaction

(2015) Guobo Shen et al.   CELL RESEARCH

Keeping Wnt Signalosome in Check by Vesicular Traffic

(2015) Qiang Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Maternal Wnt/STOP signaling promotes cell division during earlyXenopusembryogenesis

(2015) Ya-Lin Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization

(2015) Julia Madrzak et al.   Nature Communications

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

(2015) Tao-Hsin Chang et al.   eLife

LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation

(2014) Jinxiao Chen et al.   CELLULAR SIGNALLING

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

(2013) J. Ke et al.   GENES & DEVELOPMENT

Structural basis for molecular recognition of folic acid by folate receptors

(2013) Chen Chen et al.   NATURE

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

(2013) Xinxin Gao et al.   Nature Chemical Biology

Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins

(2013) Jessica Rios-Esteves et al.   Cell Reports

Structural Architecture and Functional Evolution of Wnts

(2012) J. Fernando Bazan et al.   DEVELOPMENTAL CELL

Activation of Wnt Signaling by Chemically Induced Dimerization of LRP5 Disrupts Cellular Homeostasis

(2012) Payam Shahi et al.   PLoS One

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP

(2010) Konstantinos Nikopoulos et al.   HUMAN MUTATION

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Imaging the Lipidome: ω-Alkynyl Fatty Acids for Detection and Cellular Visualization of Lipid-Modified Proteins

(2009) Rami N. Hannoush et al.   ACS Chemical Biology

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization

(2009) Matias Simons et al.   NATURE CELL BIOLOGY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology