The Neuroprotective and Neurodegeneration Effects of Heme Oxygenase-1 in Alzheimer’s Disease

An immune-cell signature marks the brain in Alzheimer’s disease

(2020) Michael T. Heneka   NATURE

Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia

(2020) Franc Llorens et al.   Nature Communications

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

(2020) Matthias Arnold et al.   Nature Communications

Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease

(2020) Nao Yan et al.   Frontiers in Neuroscience

BRAIN LIPID PEROXIDATION AND ALZHEIMER DISEASE: SYNERGY BETWEEN THE BUTTERFIELD AND MATTSON LABORATORIES

(2020) D. Allan Butterfield   AGEING RESEARCH REVIEWS

Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework

(2020) Alexios-Fotios A. Mentis et al.   MOLECULAR PSYCHIATRY

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

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The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease

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Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

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Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

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Aβ-induced vulnerability propagates via the brain’s default mode network

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

B cells in autoimmune and neurodegenerative central nervous system diseases

(2019) Joseph J. Sabatino et al.   NATURE REVIEWS NEUROSCIENCE

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

Cognitive symptoms of Alzheimer’s disease: clinical management and prevention

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Associations Between the Apolipoprotein E ε4 Allele and Reduced Serum Levels of High Density Lipoprotein a Cognitively Normal Aging Han Chinese Population

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Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

(2018) Stefan Teipel et al.   Alzheimers & Dementia

The National Institute on Aging—Alzheimer's Association Framework on Alzheimer's disease: Application to clinical trials

(2018) Jeffrey Cummings   Alzheimers & Dementia

A novel heme oxygenase-1 splice variant, 14kDa HO-1, promotes cell proliferation and increases relative telomere length

(2018) Chunxiang Bian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease

(2018) Wenyu Jiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens

(2018) Matthew Zabel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Heme Oxygenase 1 Induces Tau Oligomer Formation and Synapse Aberrations in Hippocampal Neurons

(2018) Zizhen Si et al.   JOURNAL OF ALZHEIMERS DISEASE

Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection

(2018) Alexander J. Gill et al.   Journal of Neuroinflammation

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

microRNA-494 Favors HO-1 Expression in Neuroblastoma Cells Exposed to Oxidative Stress in a Bach1-Independent Way

(2018) Sabrina Piras et al.   Frontiers in Oncology

Effect of Cerebral Amyloid Angiopathy on Brain Iron, Copper, and Zinc in Alzheimer's Disease

(2018) Matthew Schrag et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Overexpression of Heme Oxygenase 1 Promotes Tau Aggregation in Mouse Brain by Inducing Tau Phosphorylation

(2018) Yang Hui et al.   JOURNAL OF ALZHEIMERS DISEASE

HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease

(2018) Fabio Di Domenico et al.   JOURNAL OF ALZHEIMERS DISEASE

Overexpression of Heme Oxygenase 1 Causes Cognitive Decline and Affects Pathways for Tauopathy in Mice

(2018) Dayong Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The sinister face of heme oxygenase-1 in brain aging and disease

(2018) Hyman M. Schipper et al.   PROGRESS IN NEUROBIOLOGY

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

(2018) Piyoosh Sharma et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of microRNA-153 protects neurons against ischemia/reperfusion injury in an oxygen-glucose deprivation and reoxygenation cellular model by regulating Nrf2/HO-1 signaling

(2017) Qiong Ji et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The phenotypical core of Alzheimer's disease-related and nonrelated variants of the corticobasal syndrome: A systematic clinical, neuropsychological, imaging, and biomarker study

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Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

(2016) Nikita Rudinskiy et al.   Alzheimers & Dementia

Amyloid biomarkers: pushing the limits of early detection

(2016) Gil D. Rabinovici   BRAIN

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

(2016) Antoine Leuzy et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Neuropsychological Effects of Cerebral Amyloid Angiopathy

(2016) Matthew Schrag et al.   Current Neurology and Neuroscience Reports

BACH1, the master regulator gene: A novel candidate target for cancer therapy

(2016) Sadaf Davudian et al.   GENE

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer's disease

(2016) Kedar N. Prasad   MECHANISMS OF AGEING AND DEVELOPMENT

High-Glucose-Derived Oxidative Stress-Dependent Heme Oxygenase-1 Expression from Astrocytes Contributes to the Neuronal Apoptosis

(2016) Chuen-Mao Yang et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease

(2016) T A Pascoal et al.   MOLECULAR PSYCHIATRY

Is aceruloplasminemia treatable? Combining iron chelation and fresh-frozen plasma treatment

(2016) L. Poli et al.   NEUROLOGICAL SCIENCES

Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets

(2016) Sun-Ho Han et al.   PROGRESS IN NEUROBIOLOGY

Alzheimer’s disease due to loss of function: A new synthesis of the available data

(2016) Kasper P. Kepp   PROGRESS IN NEUROBIOLOGY

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

(2016) Rawan Tarawneh et al.   JAMA Neurology

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

(2015) Jessica M. Mc Donald et al.   Alzheimers & Dementia

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Is glial heme oxygenase-1 suppression in neurodegenerative disorders permissive for neural repair?

(2015) HymanM Schipper   Neural Regeneration Research

Neurotherapeutic effects of novel HO-1 inhibitorsin vitroand in a transgenic mouse model of Alzheimer's disease

(2015) Ajay Gupta et al.   JOURNAL OF NEUROCHEMISTRY

HO-1 attenuates hippocampal neurons injury via the activation of BDNF–TrkB–PI3K/Akt signaling pathway in stroke

(2014) Dashi Qi et al.   BRAIN RESEARCH

Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses

(2014) Chhanda Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity

(2014) F-F Hsu et al.   ONCOGENE

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Heme oxygenase-1 protects against Alzheimer’s amyloid-β1-42-induced toxicity via carbon monoxide production

(2014) N Hettiarachchi et al.   Cell Death & Disease

Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis

(2013) Xinghua Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in Neurodegenerative Diseases

(2012) Agnieszka Jazwa et al.   CURRENT DRUG TARGETS

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Inorganic Polyphosphate and Energy Metabolism in Mammalian Cells

(2010) Evgeny Pavlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim

(2010) Hyman M. Schipper   JOURNAL OF NEURAL TRANSMISSION

A Novel Experimental Heme Oxygenase-1-Targeted Therapy for Hormone-Refractory Prostate Cancer

(2009) M. A. Alaoui-Jamali et al.   CANCER RESEARCH

Suppression of Glial HO-1 Activitiy as a Potential Neurotherapeutic Intervention in AD

(2009) Hyman Schipper et al.   Current Alzheimer Research

Quality of life among older grandparent caregivers: a pilot study

(2009) Meihan Lo et al.   JOURNAL OF ADVANCED NURSING

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

(2009) Hyman M. Schipper et al.   JOURNAL OF NEUROCHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression

(2009) Shih-Ya Hung et al.   NEUROPHARMACOLOGY

Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities

(2008) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders

(2008) P J Syapin   BRITISH JOURNAL OF PHARMACOLOGY

Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology

(2008) Jozef Dulak et al.   CIRCULATION

Heme Oxygenase-1 as a Therapeutic Target in Neurodegenerative Diseases and Brain Infections

(2008) Antonio Cuadrado et al.   CURRENT PHARMACEUTICAL DESIGN

Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

(2008) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin E-dependent localization of MCM5 regulates centrosome duplication

(2008) R. L. Ferguson et al.   JOURNAL OF CELL SCIENCE

Impact of heme oxygenase-1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia

(2008) Jacob R. Hascalovici et al.   JOURNAL OF NEUROCHEMISTRY

Bilirubin as an endogenous modulator of neurotrophin redox signaling

(2008) Cesare Mancuso et al.   JOURNAL OF NEUROSCIENCE RESEARCH