Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease

PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer’s Disease Brain

(2020) Prashant Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy modulates Aβ accumulation and formation of aggregates in yeast

(2020) Prashant R. Bharadwaj et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy

(2020) Mehrnaz Haghi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

High‐frequency transcranial magnetic stimulation protects APP/PS1 mice against Alzheimer’s disease progress by reducing APOE and enhancing autophagy

(2020) Xia Chen et al.   Brain and Behavior

Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain

(2020) Dawn H.W. Lau et al.   NEUROBIOLOGY OF DISEASE

Hallmarks of Aging: An Autophagic Perspective

(2019) María Carolina Barbosa et al.   Frontiers in Endocrinology

The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy

(2019) Katarzyna Zientara-Rytter et al.   Cells

Protein damage, ageing and age-related diseases

(2019) Anita Krisko et al.   Open Biology

Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process

(2019) Manon Domise et al.   Cell Death & Disease

Autophagy in aging and longevity

(2019) Shi Q. Wong et al.   HUMAN GENETICS

Autophagy Promotes Memory Formation

(2019) Timir Tripathi et al.   ACS Chemical Neuroscience

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

(2019) Qiong Feng et al.   Autophagy

Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance

(2019) L. Passamonti et al.   JOURNAL OF NEUROSCIENCE

Autophagy Modulation as a Treatment of Amyloid Diseases

(2019) Zoe Mputhia et al.   MOLECULES

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities

(2019) Jie Liu et al.   Frontiers in Molecular Neuroscience

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

(2019) Bilal R. Malik et al.   Molecular Brain

Genetics of Alzheimer’s disease: where we are, and where we are going

(2019) Céline Bellenguez et al.   CURRENT OPINION IN NEUROBIOLOGY

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

(2018) Karolina Pierzynowska et al.   METABOLIC BRAIN DISEASE

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort

(2018) Jan Verheijen et al.   NEUROBIOLOGY OF AGING

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast

(2018) Prashant R. Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Next Generation Sequencing Analysis in Early Onset Dementia Patients

(2018) Cristian Bonvicini et al.   JOURNAL OF ALZHEIMERS DISEASE

The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan

(2017) Justin Minnerly et al.   PLoS Genetics

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mechanisms of Selective Autophagy

(2016) Gabriele Zaffagnini et al.   JOURNAL OF MOLECULAR BIOLOGY

Loss ofO-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration

(2016) Andrew C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

(2016) Varun K. Gupta et al.   PLOS BIOLOGY

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease

(2015) Kunikazu Tanji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization

(2015) Carlos Pomilio et al.   HIPPOCAMPUS

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy receptor defects and ALS-FTLD

(2015) Veronika Majcher et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study

(2015) Elise Cuyvers et al.   NEUROBIOLOGY OF AGING

Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

(2015) Kevin W. Tipping et al.   TRENDS IN BIOCHEMICAL SCIENCES

SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy

(2014) Mónika Lippai et al.   Autophagy

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Glia in the pathogenesis of neurodegenerative diseases

(2014) Alexei Verkhratsky et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians

(2014) Enzo Emanuele et al.   REJUVENATION RESEARCH

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

(2014) Fan Zhang et al.   Nature Communications

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

(2013) C-W Tsai et al.   Cell Death & Disease

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

(2013) P R Bharadwaj et al.   Translational Psychiatry

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants

(2012) Fanggeng Zou et al.   PLoS Genetics

Morphological and biochemical studies on aging and autophagy

(2011) Rita Rezzani et al.   AGEING RESEARCH REVIEWS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2

(2011) Naoki Watanabe   INTERNATIONAL JOURNAL OF ONCOLOGY

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Autophagy as a Mediator of Life and Death

(2011) Julien Puyal et al.   NEUROSCIENTIST

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Protein misfolding disorders and macroautophagy

(2010) Fiona M Menzies et al.   CURRENT OPINION IN CELL BIOLOGY

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Autophagy and innate immunity: Triggering, targeting and tuning

(2010) Rhea Sumpter et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

(2010) J J Rodríguez et al.   Cell Death & Disease

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Enhancement of Autophagic Flux after Neonatal Cerebral Hypoxia-Ischemia and Its Region-Specific Relationship to Apoptotic Mechanisms

(2009) Vanessa Ginet et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting autophagy to prevent neonatal stroke damage

(2009) Julien Puyal et al.   Autophagy

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Autophagy in disease: a double-edged sword with therapeutic potential

(2009) Wim Martinet et al.   CLINICAL SCIENCE

The structure and function of Alzheimer’s gamma secretase enzyme complex

(2009) Sudarsan Krishnaswamy et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Aβ aggregation and possible implications in Alzheimer's disease pathogenesis

(2009) Prashant R. Bharadwaj et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease

(2008) Dun-Sheng Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY