Review
Cell Biology
Wei Liu, Chengpeng Yu, Jianfeng Li, Jiwei Fang
Summary: This paper provides a systematic summary of the roles of EphB2 in cancer and proposes future research prospects focusing on the effects of EphB2 on tumor immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Hoi-Wing Leung, Carmen Oi Ning Leung, Eunice Y. Lau, Katherine Po Sin Chung, Etienne H. Mok, Martina Mang Leng Lei, Rainbow Wing Hei Leung, Man Tong, Vincent W. Keng, Cong Ma, Qian Zhao, Irene Oi Lin Ng, Stephanie Ma, Terence K. Lee
Summary: This study identified a EPHB2/beta-catenin/TCF1 positive feedback loop that enhances cancer stemness and sorafenib resistance in HCC, providing a targetable axis to combat acquired drug resistance in HCC.
Article
Neurosciences
Ahlem Assali, Jennifer Y. Cho, Evgeny Tsvetkov, Abha R. Gupta, Christopher W. Cowan
Summary: Autism spectrum disorder (ASD) is characterized by impairments in social communication and interaction as well as restricted, repetitive behaviors. A de novo nonsense mutation in EPH82 was discovered in a female patient with ASD, suggesting EPH82 as a candidate ASD risk gene. EphB2 hypofunction was found to be sufficient to produce ASD-associated behaviors and altered cortical functions, particularly in females, in mice.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Ying-Chen Chen, Chu-Yen Chien, Chia-Chen Hsu, Chien-Hsing Lee, Yu-Ting Chou, Shine-Gwo Shiah, Shyun-Yeu Liu, Ching-Yu Yen, Alexander Cheng-Ting Hsieh, Martin Wabitsch, Yi-Shing Shieh
Summary: This study demonstrates that leptin-mediated AXL signaling pathway activation contributes to 5-FU resistance in colorectal cancer, suggesting a novel therapeutic strategy for colorectal cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Kazushi Hara, Yosuke Horikoshi, Masaki Morimoto, Kazuhiro Nakaso, Teppei Sunaguchi, Tatsuyuki Kurashiki, Yuji Nakayama, Takehiko Hanaki, Manabu Yamamoto, Teruhisa Sakamoto, Yoshiyuki Fujiwara, Tatsuya Matsura
Summary: Pancreatic cancer (PC) is an aggressive malignancy with limited treatment options. This study investigated the relationship between TYRO3 expression and PC chemoresistance. It was found that TYRO3 knockdown decreased cell viability and enhanced apoptosis in PC cells treated with gemcitabine and 5-fluorouracil (5-FU), while TYRO3 overexpression had no such effects. Furthermore, the study revealed that the TYRO3-autophagy signaling pathway contributes to PC resistance to gemcitabine and 5-FU, suggesting it as a potential therapeutic target for overcoming PC chemoresistance.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Oncology
Samanta Jerin, Amanda J. Harvey, Annabelle Lewis
Summary: Protein tyrosine kinase 6 (PTK6) is a biomarker of poor prognosis in breast cancer and has potential significance in colorectal cancer. PTK6 phosphorylates multiple substrates involved in colorectal cancer pathways and is overexpressed in colorectal tumors. Targeting PTK6 in colorectal cancer may enhance sensitivity to chemotherapy.
Article
Pharmacology & Pharmacy
Grazia Bellese, Erica Tagliatti, Maria Cristina Gagliani, Sara Santamaria, Pietro Arnaldi, Paola Falletta, Paola Rusmini, Michela Matteoli, Patrizio Castagnola, Katia Cortese
Summary: This study investigated the effects of a drug called Neratinib on ERBB2+ breast cancer cells. It was found that Neratinib inhibited critical cell survival processes, including multiple signaling pathways and DNA damage response, inducing cell cycle arrest, early apoptosis, and transient autophagy. These effects may be mediated by altered expression of the chromatin transcription factors TFEB and TFE3.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sareshma Sudhesh Dev, Syafiq Asnawi Zainal Abidin, Reyhaneh Farghadani, Iekhsan Othman, Rakesh Naidu
Summary: Receptor tyrosine kinases (RTKs) are crucial cell-surface proteins that regulate essential cellular processes, with alterations in them playing a key role in cancer progression. Curcumin, as an attractive anti-cancer agent, exhibits potent effects by inhibiting RTKs and downstream signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Christopher Xie, Dipon K. Mondal, Mikdat Ulas, Thomas Neill, Renato Iozzo
Summary: Decorin is a prototype member of the small leucine-rich proteoglycan gene family derived from stromal cells. It functions as a regulator of collagen fibrillogenesis and TGF-beta activity, and also acts as a pan-receptor tyrosine kinase (RTK) inhibitor. Decorin binds to various RTKs and transiently activates them, suppressing downstream signaling cascades and leading to growth inhibition. Decorin also restricts cancer growth and dissemination by impeding angiogenesis and inducing endothelial cell autophagy. Overall, decorin has the potential to be used as a protein-based adjuvant therapy to combat cancer.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Xu, Dorothea Robev, Nayanendu Saha, Bingcheng Wang, Matthew B. Dalva, Kai Xu, Juha P. Himanen, Dimitar B. Nikolov
Summary: Eph receptor tyrosine kinases and ephrin ligands play crucial roles in cell communication, with dysfunctional signaling leading to disease. The formation of extensive signaling assemblies regulates neuronal migration and axon pathfinding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sakshi Arora, Andrew M. Scott, Peter W. Janes
Summary: Eph receptor tyrosine kinases play critical roles in development and tissue formation, and are regulated by membrane-bound ligands ephrins. They have low expression in adults, but are often overexpressed in cancers, where they are associated with tumour development, vasculature, and invasion. Understanding the opposing roles of Ephs in different cancers is crucial for developing targeted therapies.
Article
Multidisciplinary Sciences
Pei -Ling Hsu, Chun -Wei Chien, Yen-An Tang, Bo -Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai
Summary: Metastasis is the main cause of death in many cancers including colorectal cancer (CRC), but the underlying mechanisms are largely unknown. This study found that the nuclear TYRO3 receptor tyrosine kinase is a strong predictor of poor overall survival in patients with CRC. The function of nuclear TYRO3 in promoting metastasis requires its kinase activity and MMP-2-mediated cleavage, independent of ligand binding. The research also identified BRD3 as one of nuclear TYRO3's substrates and demonstrated that TYRO3-phosphorylated BRD3 regulates genes involved in anti-apoptosis and epithelial-mesenchymal transition.
Article
Multidisciplinary Sciences
Febina Ravindran, Jinsha Koroth, Meghana Manjunath, Suchitra Narayan, Bibha Choudhary
Summary: ST09 is a potent drug candidate for ovarian cancer treatment, exhibiting anti-invasive and migrastatic properties. It exerts tumor-suppressive functions by affecting the miR-199a-5p/DDR1 axis, resulting in DDR1 loss in ovarian cancer cells and inactivation of downstream MMP activation, migration, EMT, and prosurvival NF-kappa B pathway.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Maria Belen Novoa Diaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
Summary: PTHrP regulates Met expression in CRC cells and is involved in the aggressive behavior of CRC cells. Inhibition of specific signaling pathways reverses the effects of PTHrP on Met activation and cell migration, and PTHrP promotes chemoresistance in CRC cells through the Met pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vignesh Sivaganesh, Varsha Sivaganesh, Christina Scanlon, Alexander Iskander, Salma Maher, Thu Le, Bela Peethambaran
Summary: Protein tyrosine phosphatases (PTPs) have emerged as a new target in cancer therapy, with both tumor-suppressive and oncogenic properties. This review focuses on key PTPs investigated in various cancers and explores the different mechanisms underlying pro-cancerous and anti-cancerous effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Maki Goto, Kageaki Kuribayashi, Yusuke Takahashi, Takashi Kondoh, Maki Tanaka, Daisuke Kobayashi, Naoki Watanabe
BRITISH JOURNAL OF HAEMATOLOGY
(2013)
Article
Cell Biology
Kageaki Kuribayashi, Niklas Finnberg, John R. Jeffers, Gerard P. Zambetti, Wafik S. El-Deiry
Article
Oncology
Ryosei Murai, Maki Tanaka, Yusuke Takahashi, Kageaki Kuribayashi, Daisuke Kobayashi, Naoki Watanabe
CLINICAL & EXPERIMENTAL METASTASIS
(2014)
Article
Medicine, General & Internal
Kageaki Kuribayashi, Akihito Fujimi, Masayoshi Kobune, Rishu Takimoto, Shohei Kikuchi, Satoshi Iyama, Junji Kato, Yoshiro Niitsu, Naoki Watanabe
Article
Oncology
Chihiro Onoda, Kageaki Kuribayashi, Shinya Nirasawa, Naoki Tsuji, Maki Tanaka, Daisuke Kobayashi, Naoki Watanabe
INTERNATIONAL JOURNAL OF ONCOLOGY
(2011)
Article
Oncology
Takashi Kondoh, Kageaki Kuribayashi, Maki Tanaka, Daisuke Kobayashi, Nozomi Yanagihara, Naoki Watanabe
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Oncology
Yoshifumi Umemori, Kageaki Kuribayashi, Shinya Nirasawa, Takashi Kondoh, Maki Tanaka, Daisuke Kobayashi, Naoki Watanabe
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Biochemical Research Methods
Ryosei Murai, Koji Yamada, Maki Tanaka, Kageaki Kuribayashi, Daisuke Kobayashi, Naoki Tsuji, Naoki Watanabe
JOURNAL OF IMMUNOLOGICAL METHODS
(2013)
Article
Oncology
Maki Tanaka, Kageaki Kuribayashi, Kastuhisa Kogawa, Kiminori Nakamura, Naoki Watanabe
Article
Immunology
Masaaki Shinagawa, Daisuke Kobayashi, Maki Goto, Maki Tanaka, Kageaki Kuribayashi, Nozomi Yanagihara, Naoki Watanabe
MICROBIAL PATHOGENESIS
(2014)
Article
Chemistry, Medicinal
Yusuke Takahashi, Maki Tanaka, Ryosei Murai, Kageaki Kuribayashi, Daisuke Kobayashi, Nozomi Yanagihara, Naoki Watanabe
PHYTOTHERAPY RESEARCH
(2014)
Article
Medicine, Research & Experimental
Hirohito Suzuki, Maki Tanaka, Katsuya Kawanishi, Hisashi Koshino, Toshihiro Hirai, Hirotada Fujii, Hidekatsu Takeda, Kageaki Kuribayashi, Naoki Watanabe
Article
Biotechnology & Applied Microbiology
Kaori Morota, Makoto Komori, Ryo Fujinami, Koji Yamada, Kageaki Kuribayashi, Naoki Watanabe, Lori J. Sokoll, Debra Elliott, Daniel W. Chan, Frans Martens, Annemieke C. Heijboer, Marinus A. Blankenstein, Stefan J. Hershberger, Zachary A. Pfeiffer, Shyam V. Vaidya, Barry L. Dowell
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2012)
Article
Infectious Diseases
Daisuke Furuya, Kageaki Kuribayashi, Yukie Hosono, Naoki Tsuji, Momoko Furuya, Kanako Miyazaki, Naoki Watanabe
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2011)