Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation

(2018) Chiara Vidoni et al.   NEUROCHEMISTRY INTERNATIONAL

Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model

(2018) Karolina Pierzynowska et al.   NEUROMOLECULAR MEDICINE

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells

(2018) Robin S.B. Williams et al.   NEUROPHARMACOLOGY

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

(2018) Xin Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Pimozide reduces toxic forms of tau in TauC3 mice via 5′ adenosine monophosphate-activated protein kinase-mediated autophagy

(2017) Young Doo Kim et al.   JOURNAL OF NEUROCHEMISTRY

An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease

(2017) Benjamin R. Underwood et al.   JOURNAL OF NEUROLOGY

Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells

(2017) Juan Zhao et al.   MOLECULES

Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer’s disease mouse model: possible involvement of the cholinergic system

(2017) Mirna Ezzat Sorial et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy

(2017) Y. Zhang et al.   NEUROSCIENCE LETTERS

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

(2017) Lijuan Zhang et al.   MEDICAL SCIENCE MONITOR

Gender difference in valproic acid-induced neuroprotective effects on APP/PS1 double transgenic mice modeling Alzheimer's disease

(2016) Zhimin Long et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Rag GTPase in amino acid signaling

(2016) Joungmok Kim et al.   AMINO ACIDS

Lithium chloride could aggravate brain injury caused by 3-nitropropionic acid

(2016) Aleksandra Milutinović   Bosnian Journal of Basic Medical Sciences

Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease

(2016) Hanaa Hibishy Gaballah et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease

(2016) Gabriel R. Linares et al.   EXPERIMENTAL NEUROLOGY

Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development

(2016) Juan Perucho et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

(2016) Yan-Jie Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA 2 dependent signalling

(2016) Robin S.B. Williams et al.   NEUROPHARMACOLOGY

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

(2016) Qiuyang Zheng et al.   Frontiers in Aging Neuroscience

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

(2014) F M Menzies et al.   CELL DEATH AND DIFFERENTIATION

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

(2014) M. Schiebler et al.   EMBO Molecular Medicine

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

(2014) Meike Diepenbroek et al.   HUMAN MOLECULAR GENETICS

Preclinical and Clinical Investigations of Mood Stabilizers for Huntington's Disease: What Have We Learned?

(2014) Lisa Scheuing et al.   International Journal of Biological Sciences

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity

(2014) Matthias Höllerhage et al.   NEUROBIOLOGY OF AGING

Targeting autophagy in neurodegenerative diseases

(2014) René L. Vidal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Challenges in the clinical development of PI3K inhibitors

(2013) Cristian Massacesi et al.   Annals of the New York Academy of Sciences

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

Calcium channel blockers and dementia

(2013) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity

(2013) Jungwon Seo et al.   FEBS Journal

Neuroprotective Effects of Psychotropic Drugs in Huntington’s Disease

(2013) Edward Lauterbach   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lithium Down-regulates Histone Deacetylase 1 (HDAC1) and Induces Degradation of Mutant Huntingtin

(2013) Shuai Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse

(2013) Kathleen M. Schoch et al.   JOURNAL OF NEUROCHEMISTRY

High dose genistein aglycone therapy is safe in patients with mucopolysaccharidoses involving the central nervous system

(2013) Katherine H. Kim et al.   MOLECULAR GENETICS AND METABOLISM

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Modeling Parkinson's Disease in Primates: The MPTP Model

(2013) G. Porras et al.   Cold Spring Harbor Perspectives in Medicine

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

(2013) P R Bharadwaj et al.   Translational Psychiatry

Off label use of lithium in the treatment of Huntington′s disease: A case series

(2013) Vijay Danivas et al.   Indian Journal of Psychiatry

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

Therapeutic Effects of Valproate Combined With Lithium Carbonate on MPTP-Induced Parkinsonism in Mice: Possible Mediation Through Enhanced Autophagy

(2012) Xue-zhong Li et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein

(2012) Dan-Mei Lan et al.   NEUROCHEMICAL RESEARCH

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Molecular machinery of macroautophagy and its deregulation in diseases

(2011) Alan S.L. Wong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Chaperone-mediated autophagy at a glance

(2011) S. Kaushik et al.   JOURNAL OF CELL SCIENCE

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

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(2011) Daniel Paris et al.   MOLECULAR MEDICINE

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Regulation of lipid droplets by autophagy

(2011) Hanqing Dong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism

(2010) J.S. Schneider et al.   BEHAVIOURAL BRAIN RESEARCH

Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats

(2010) Harikesh Kalonia et al.   BRAIN RESEARCH

Genistein reduces glycosaminoglycan levels in a mouse model of mucopolysaccharidosis type II

(2010) A Friso et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

(2010) Daniel J. Ho et al.   EXPERIMENTAL NEUROLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms

(2010) S. Mitterreiter et al.   JOURNAL OF NEUROSCIENCE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

(2010) Isaac Túnez et al.   MOLECULES

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Prevalence of Diabetes among Men and Women in China

(2010) Wenying Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia☆

(2010) Xiao-Wen Liu et al.   PHARMACOLOGICAL RESEARCH

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease

(2010) Marcelina Malinowska et al.   PLoS One

Autophagy and Tumorigenesis

(2010) Srirupa Roy et al.   Seminars in Immunopathology

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Autophagy genes as tumor suppressors

(2009) Chengyu Liang et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation

(2009) Jennifer S. Carew et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial

(2009) Clive Ballard et al.   LANCET NEUROLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice

(2009) Marcelina Malinowska et al.   MOLECULAR GENETICS AND METABOLISM

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Autophagy genes and ageing

(2008) T Vellai   CELL DEATH AND DIFFERENTIATION

Huntington’s disease: degradation of mutant huntingtin by autophagy

(2008) Sovan Sarkar et al.   FEBS Journal

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

(2008) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

(2008) Déborah Tribouillard-Tanvier et al.   PLoS One

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

(2008) S. Tsukamoto et al.   SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

A Randomised, Blinded, Placebo-Controlled Trial in Dementia Patients Continuing or Stopping Neuroleptics (The DART-AD Trial)

(2008) Clive Ballard et al.   PLOS MEDICINE

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE